Thermoresponsive triblock copolymers as widely applicable 19F magnetic resonance imaging tracers
- Author
- Kristyna Kolouchova (UGent) , Ondrej Groborz, Miroslav Slouf, Vit Herynek, Laurens Parmentier (UGent) , David Babuka, Zulfiya Cernochova, Filip Koucky, Ondrej Sedlacek (UGent) , Martin Hruby, Richard Hoogenboom (UGent) and Sandra Van Vlierberghe (UGent)
- Organization
- Project
- Abstract
- Fluorine-19 magnetic resonance imaging (19F MRI) has emerged as a promising noninvasive diagnostic tool, broad-ening the diagnostic possibilities of commonly used proton MRI. Despite the potential of 19F MRI, an ideal tracer paving the way toward the entry of this method into common medical practice is yet to be developed. In this study, we report on a series of polymeric systems based on thermoresponsive poly[N-(2,2-difluoroethyl)acrylamide] (PDFEA), a polymer considered to be an ideal tracer for 19F MRI. The described systems are designed as BAB triblock copolymers, where B corresponds to thermores-ponsive PDFEA blocks and A is a hydrophilic poly(ethylene glycol) block. These BAB triblock copolymers are able to form nanoparticles in dilute aqueous solutions, which undergo a transition into physically cross-linked hydrogels upon increasing the polymer concentration. Since thermoresponsive particle-and hydrogel-based systems are applicable in a wide range of biomedical applications, we created a diagnostic system with potential therapeutic properties (theranostic) as a widely tunable platform through straightforward synthesis while serving a multitude of applications. We analyzed the effect of the BAB block ratio on the self-assembly, thermoresponsiveness, and mechanical properties of the studied hydrogels, together with their suitability for 19F MRI. Finally, their biocompatibility was assessed on a relevant cell line.
- Keywords
- DRUG-DELIVERY, POLYMER, F-19, HYDROGELS, BEHAVIOR, MRI, ABA, NANOPARTICLES, BIODISTRIBUTION, TEMPERATURE
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Please use this url to cite or link to this publication: http://hdl.handle.net/1854/LU-01GVDGDMFGYR7091MD4E3BSSQR
- MLA
- Kolouchova, Kristyna, et al. “Thermoresponsive Triblock Copolymers as Widely Applicable 19F Magnetic Resonance Imaging Tracers.” CHEMISTRY OF MATERIALS, vol. 34, no. 24, Amer Chemical Soc., 2022, pp. 10902–16, doi:10.1021/acs.chemmater.2c02589.
- APA
- Kolouchova, K., Groborz, O., Slouf, M., Herynek, V., Parmentier, L., Babuka, D., … Van Vlierberghe, S. (2022). Thermoresponsive triblock copolymers as widely applicable 19F magnetic resonance imaging tracers. CHEMISTRY OF MATERIALS, 34(24), 10902–10916. https://doi.org/10.1021/acs.chemmater.2c02589
- Chicago author-date
- Kolouchova, Kristyna, Ondrej Groborz, Miroslav Slouf, Vit Herynek, Laurens Parmentier, David Babuka, Zulfiya Cernochova, et al. 2022. “Thermoresponsive Triblock Copolymers as Widely Applicable 19F Magnetic Resonance Imaging Tracers.” CHEMISTRY OF MATERIALS 34 (24): 10902–16. https://doi.org/10.1021/acs.chemmater.2c02589.
- Chicago author-date (all authors)
- Kolouchova, Kristyna, Ondrej Groborz, Miroslav Slouf, Vit Herynek, Laurens Parmentier, David Babuka, Zulfiya Cernochova, Filip Koucky, Ondrej Sedlacek, Martin Hruby, Richard Hoogenboom, and Sandra Van Vlierberghe. 2022. “Thermoresponsive Triblock Copolymers as Widely Applicable 19F Magnetic Resonance Imaging Tracers.” CHEMISTRY OF MATERIALS 34 (24): 10902–10916. doi:10.1021/acs.chemmater.2c02589.
- Vancouver
- 1.Kolouchova K, Groborz O, Slouf M, Herynek V, Parmentier L, Babuka D, et al. Thermoresponsive triblock copolymers as widely applicable 19F magnetic resonance imaging tracers. CHEMISTRY OF MATERIALS. 2022;34(24):10902–16.
- IEEE
- [1]K. Kolouchova et al., “Thermoresponsive triblock copolymers as widely applicable 19F magnetic resonance imaging tracers,” CHEMISTRY OF MATERIALS, vol. 34, no. 24, pp. 10902–10916, 2022.
@article{01GVDGDMFGYR7091MD4E3BSSQR,
abstract = {{Fluorine-19 magnetic resonance imaging (19F MRI) has emerged as a promising noninvasive diagnostic tool, broad-ening the diagnostic possibilities of commonly used proton MRI. Despite the potential of 19F MRI, an ideal tracer paving the way toward the entry of this method into common medical practice is yet to be developed. In this study, we report on a series of polymeric systems based on thermoresponsive poly[N-(2,2-difluoroethyl)acrylamide] (PDFEA), a polymer considered to be an ideal tracer for 19F MRI. The described systems are designed as BAB triblock copolymers, where B corresponds to thermores-ponsive PDFEA blocks and A is a hydrophilic poly(ethylene glycol) block. These BAB triblock copolymers are able to form nanoparticles in dilute aqueous solutions, which undergo a transition into physically cross-linked hydrogels upon increasing the polymer concentration. Since thermoresponsive particle-and hydrogel-based systems are applicable in a wide range of biomedical applications, we created a diagnostic system with potential therapeutic properties (theranostic) as a widely tunable platform through straightforward synthesis while serving a multitude of applications. We analyzed the effect of the BAB block ratio on the self-assembly, thermoresponsiveness, and mechanical properties of the studied hydrogels, together with their suitability for 19F MRI. Finally, their biocompatibility was assessed on a relevant cell line.}},
author = {{Kolouchova, Kristyna and Groborz, Ondrej and Slouf, Miroslav and Herynek, Vit and Parmentier, Laurens and Babuka, David and Cernochova, Zulfiya and Koucky, Filip and Sedlacek, Ondrej and Hruby, Martin and Hoogenboom, Richard and Van Vlierberghe, Sandra}},
issn = {{0897-4756}},
journal = {{CHEMISTRY OF MATERIALS}},
keywords = {{DRUG-DELIVERY,POLYMER,F-19,HYDROGELS,BEHAVIOR,MRI,ABA,NANOPARTICLES,BIODISTRIBUTION,TEMPERATURE}},
language = {{eng}},
number = {{24}},
pages = {{10902--10916}},
publisher = {{Amer Chemical Soc.}},
title = {{Thermoresponsive triblock copolymers as widely applicable 19F magnetic resonance imaging tracers}},
url = {{http://doi.org/10.1021/acs.chemmater.2c02589}},
volume = {{34}},
year = {{2022}},
}
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