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Glycyrrhizin-based hydrogels accelerate wound healing of normoglycemic and diabetic mouse skin

Maarten A. Mees, Fleur Boone (UGent) , Thomas Bouwen, Frederik Vanaerschot, Charlotte Titeca, Hanna-Kaisa Vikkula (UGent) , Leen Catrysse (UGent) , Anja Vananroye, Erin Koos, Stelios Alexandris, et al.
(2023) PHARMACEUTICS. 15(1).
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Abstract
Efficient wound repair is crucial for mammalian survival. Healing of skin wounds is severely hampered in diabetic patients, resulting in chronic non-healing wounds that are difficult to treat. High-mobility group box 1 (HMGB1) is an important signaling molecule that is released during wounding, thereby delaying regenerative responses in the skin. Here, we show that dissolving glycyrrhizin, a potent HMGB1 inhibitor, in water results in the formation of a hydrogel with remarkable rheological properties. We demonstrate that these glycyrrhizin-based hydrogels accelerate cutaneous wound closure in normoglycemic and diabetic mice by influencing keratinocyte migration. To facilitate topical application of glycyrrhizin hydrogels on cutaneous wounds, several concentrations of glycyrrhizinic acid in water were tested for their rheological, structural, and biological properties. By varying the concentration of glycyrrhizin, these hydrogel properties can be readily tuned, enabling customized wound care.
Keywords
wound healing, glycyrrhizin, hydrogel, rheology, physical hydrogel, DIPOTASSIUM GLYCYRRHIZATE, GLYCYRRHETINIC ACID, LICORICE, HMGB1, PROTEIN, INFLAMMATION, NEUTROPHILS, DRESSINGS, NMR

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Citation

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MLA
Mees, Maarten A., et al. “Glycyrrhizin-Based Hydrogels Accelerate Wound Healing of Normoglycemic and Diabetic Mouse Skin.” PHARMACEUTICS, vol. 15, no. 1, 2023, doi:10.3390/pharmaceutics15010027.
APA
Mees, M. A., Boone, F., Bouwen, T., Vanaerschot, F., Titeca, C., Vikkula, H.-K., … Hoste, E. (2023). Glycyrrhizin-based hydrogels accelerate wound healing of normoglycemic and diabetic mouse skin. PHARMACEUTICS, 15(1). https://doi.org/10.3390/pharmaceutics15010027
Chicago author-date
Mees, Maarten A., Fleur Boone, Thomas Bouwen, Frederik Vanaerschot, Charlotte Titeca, Hanna-Kaisa Vikkula, Leen Catrysse, et al. 2023. “Glycyrrhizin-Based Hydrogels Accelerate Wound Healing of Normoglycemic and Diabetic Mouse Skin.” PHARMACEUTICS 15 (1). https://doi.org/10.3390/pharmaceutics15010027.
Chicago author-date (all authors)
Mees, Maarten A., Fleur Boone, Thomas Bouwen, Frederik Vanaerschot, Charlotte Titeca, Hanna-Kaisa Vikkula, Leen Catrysse, Anja Vananroye, Erin Koos, Stelios Alexandris, Sabine Rosenfeldt, Samuel Eyley, Joachim Koetz, Geert van Loo, Wim Thielemans, and Esther Hoste. 2023. “Glycyrrhizin-Based Hydrogels Accelerate Wound Healing of Normoglycemic and Diabetic Mouse Skin.” PHARMACEUTICS 15 (1). doi:10.3390/pharmaceutics15010027.
Vancouver
1.
Mees MA, Boone F, Bouwen T, Vanaerschot F, Titeca C, Vikkula H-K, et al. Glycyrrhizin-based hydrogels accelerate wound healing of normoglycemic and diabetic mouse skin. PHARMACEUTICS. 2023;15(1).
IEEE
[1]
M. A. Mees et al., “Glycyrrhizin-based hydrogels accelerate wound healing of normoglycemic and diabetic mouse skin,” PHARMACEUTICS, vol. 15, no. 1, 2023.
@article{01GTKHZAMRT7ZB4ZHDHCJWGD9K,
  abstract     = {{Efficient wound repair is crucial for mammalian survival. Healing of skin wounds is severely hampered in diabetic patients, resulting in chronic non-healing wounds that are difficult to treat. High-mobility group box 1 (HMGB1) is an important signaling molecule that is released during wounding, thereby delaying regenerative responses in the skin. Here, we show that dissolving glycyrrhizin, a potent HMGB1 inhibitor, in water results in the formation of a hydrogel with remarkable rheological properties. We demonstrate that these glycyrrhizin-based hydrogels accelerate cutaneous wound closure in normoglycemic and diabetic mice by influencing keratinocyte migration. To facilitate topical application of glycyrrhizin hydrogels on cutaneous wounds, several concentrations of glycyrrhizinic acid in water were tested for their rheological, structural, and biological properties. By varying the concentration of glycyrrhizin, these hydrogel properties can be readily tuned, enabling customized wound care.}},
  articleno    = {{27}},
  author       = {{Mees, Maarten A. and Boone, Fleur and  Bouwen, Thomas and  Vanaerschot, Frederik and  Titeca, Charlotte and Vikkula, Hanna-Kaisa and Catrysse, Leen and  Vananroye, Anja and  Koos, Erin and  Alexandris, Stelios and  Rosenfeldt, Sabine and  Eyley, Samuel and  Koetz, Joachim and van Loo, Geert and  Thielemans, Wim and Hoste, Esther}},
  issn         = {{1999-4923}},
  journal      = {{PHARMACEUTICS}},
  keywords     = {{wound healing,glycyrrhizin,hydrogel,rheology,physical hydrogel,DIPOTASSIUM GLYCYRRHIZATE,GLYCYRRHETINIC ACID,LICORICE,HMGB1,PROTEIN,INFLAMMATION,NEUTROPHILS,DRESSINGS,NMR}},
  language     = {{eng}},
  number       = {{1}},
  pages        = {{14}},
  title        = {{Glycyrrhizin-based hydrogels accelerate wound healing of normoglycemic and diabetic mouse skin}},
  url          = {{http://doi.org/10.3390/pharmaceutics15010027}},
  volume       = {{15}},
  year         = {{2023}},
}
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