Academic Bibliography

 Search 200 years of publications by Ghent University researchers.
Advanced search
1 file | 2.14 MB
Add to list
  1. Search results
  2. Direct co-registration of [18F]FDG up...

Direct co-registration of [18F]FDG uptake and histopathology in surgically excised malignancies of the head and neck : a feasibility study

Jens Debacker (UGent) , Luna Maris (UGent) , Fleur Cordier (UGent) , David Creytens (UGent) , Philippe Deron (UGent) , Benedicte Descamps (UGent) , Yves D'Asseler (UGent) , Kathia De Man (UGent) , Vincent Keereman (UGent) , Sasha Libbrecht, et al.
(2023) EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. 50(7). p.2127-2139
Author
Organization
Abstract
Purpose Recent technical advancements in PET imaging have improved sensitivity and spatial resolution. Consequently, clinical nuclear medicine will be confronted with PET images on a previously unfamiliar resolution. To better understand [F-18]FDG distribution at submillimetric scale, a direct correlation of radionuclide-imaging and histopathology is required.Methods A total of five patients diagnosed with a malignancy of the head and neck were injected with a clinical activity of [F-18]FDG before undergoing surgical resection. The resected specimen was imaged using a preclinical high-resolution PET/CT, followed by slicing of the specimen. Multiple slices were rescanned using a micro-PET/CT device, and one of the slices was snap-frozen for frozen sections. Frozen sections were placed on an autoradiographic film, followed by haematoxylin and eosin staining to prepare them for histopathological assessment. The results from both autoradiography and histopathology were co-registered using an iterative co-registration algorithm, and regions of interest were identified to study radiotracer uptake.Results The co-registration between the autoradiographs and their corresponding histopathology was successful in all specimens. The use of this novel methodology allowed direct comparison of autoradiography and histopathology and enabled the visualisation of uncharted heterogeneity in [F-18]FDG uptake in both benign and malignant tissue.Conclusion We here describe a novel methodology enabling the direct co-registration of [F-18]FDG autoradiography with the gold standard of histopathology in human malignant tissue. The future use of the current methodology could further increase our understanding of the distribution of radionuclides in surgically excised malignancies and hence, improve the integration of pathology and molecular imaging in a multiscale perspective.
Keywords
Radiology, Nuclear Medicine and imaging, General Medicine, Metabolism, Biodistribution, Tumour biology, Head and neck, Autoradiography, [F-18] FDG

Downloads

  • Download
    (...).pdf
    • full text (Published version)
    • |
    • UGent only
    • |
    • PDF
    • |
    • 2.14 MB

Citation

Please use this url to cite or link to this publication:

MLA
Debacker, Jens, et al. “Direct Co-Registration of [18F]FDG Uptake and Histopathology in Surgically Excised Malignancies of the Head and Neck : A Feasibility Study.” EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, vol. 50, no. 7, 2023, pp. 2127–39, doi:10.1007/s00259-023-06153-z.
APA
Debacker, J., Maris, L., Cordier, F., Creytens, D., Deron, P., Descamps, B., … Huvenne, W. (2023). Direct co-registration of [18F]FDG uptake and histopathology in surgically excised malignancies of the head and neck : a feasibility study. EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, 50(7), 2127–2139. https://doi.org/10.1007/s00259-023-06153-z
Chicago author-date
Debacker, Jens, Luna Maris, Fleur Cordier, David Creytens, Philippe Deron, Benedicte Descamps, Yves D’Asseler, et al. 2023. “Direct Co-Registration of [18F]FDG Uptake and Histopathology in Surgically Excised Malignancies of the Head and Neck : A Feasibility Study.” EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING 50 (7): 2127–39. https://doi.org/10.1007/s00259-023-06153-z.
Chicago author-date (all authors)
Debacker, Jens, Luna Maris, Fleur Cordier, David Creytens, Philippe Deron, Benedicte Descamps, Yves D’Asseler, Kathia De Man, Vincent Keereman, Sasha Libbrecht, Vanessa Schelfhout, Koen Van de Vijver, Christian Vanhove, and Wouter Huvenne. 2023. “Direct Co-Registration of [18F]FDG Uptake and Histopathology in Surgically Excised Malignancies of the Head and Neck : A Feasibility Study.” EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING 50 (7): 2127–2139. doi:10.1007/s00259-023-06153-z.
Vancouver
1.
Debacker J, Maris L, Cordier F, Creytens D, Deron P, Descamps B, et al. Direct co-registration of [18F]FDG uptake and histopathology in surgically excised malignancies of the head and neck : a feasibility study. EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. 2023;50(7):2127–39.
IEEE
[1]
J. Debacker et al., “Direct co-registration of [18F]FDG uptake and histopathology in surgically excised malignancies of the head and neck : a feasibility study,” EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, vol. 50, no. 7, pp. 2127–2139, 2023.
@article{01GTK7RD4F5WZEFTTH898DH11W,
  abstract     = {{Purpose Recent technical advancements in PET imaging have improved sensitivity and spatial resolution. Consequently, clinical nuclear medicine will be confronted with PET images on a previously unfamiliar resolution. To better understand [F-18]FDG distribution at submillimetric scale, a direct correlation of radionuclide-imaging and histopathology is required.Methods A total of five patients diagnosed with a malignancy of the head and neck were injected with a clinical activity of [F-18]FDG before undergoing surgical resection. The resected specimen was imaged using a preclinical high-resolution PET/CT, followed by slicing of the specimen. Multiple slices were rescanned using a micro-PET/CT device, and one of the slices was snap-frozen for frozen sections. Frozen sections were placed on an autoradiographic film, followed by haematoxylin and eosin staining to prepare them for histopathological assessment. The results from both autoradiography and histopathology were co-registered using an iterative co-registration algorithm, and regions of interest were identified to study radiotracer uptake.Results The co-registration between the autoradiographs and their corresponding histopathology was successful in all specimens. The use of this novel methodology allowed direct comparison of autoradiography and histopathology and enabled the visualisation of uncharted heterogeneity in [F-18]FDG uptake in both benign and malignant tissue.Conclusion We here describe a novel methodology enabling the direct co-registration of [F-18]FDG autoradiography with the gold standard of histopathology in human malignant tissue. The future use of the current methodology could further increase our understanding of the distribution of radionuclides in surgically excised malignancies and hence, improve the integration of pathology and molecular imaging in a multiscale perspective.}},
  author       = {{Debacker, Jens and Maris, Luna and Cordier, Fleur and Creytens, David and Deron, Philippe and Descamps, Benedicte and D'Asseler, Yves and De Man, Kathia and Keereman, Vincent and Libbrecht, Sasha and Schelfhout, Vanessa and Van de Vijver, Koen and Vanhove, Christian and Huvenne, Wouter}},
  issn         = {{1619-7070}},
  journal      = {{EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING}},
  keywords     = {{Radiology, Nuclear Medicine and imaging,General Medicine,Metabolism,Biodistribution,Tumour biology,Head and neck,Autoradiography,[F-18] FDG}},
  language     = {{eng}},
  number       = {{7}},
  pages        = {{2127--2139}},
  title        = {{Direct co-registration of [18F]FDG uptake and histopathology in surgically excised malignancies of the head and neck : a feasibility study}},
  url          = {{http://doi.org/10.1007/s00259-023-06153-z}},
  volume       = {{50}},
  year         = {{2023}},
}
Altmetric
View in Altmetric
Web of Science
Times cited: