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Investigating the development of the autonomic nervous system in infancy through pupillometry

Lyssa M. de Vries, Steffie Amelynck, Pär Nyström, Lotte van Esch, Thijs Van Lierde, Petra Warreyn (UGent) , Herbert Roeyers (UGent) , Ilse Noens, Gunnar Naulaers, Bart Boets, et al.
(2023) JOURNAL OF NEURAL TRANSMISSION. 130. p.723-734
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Abstract
We aim to investigate early developmental trajectories of the autonomic nervous system (ANS) as indexed by the pupillary light reflex (PLR) in infants with (i.e. preterm birth, feeding difficulties, or siblings of children with autism spectrum disorder) and without (controls) increased likelihood for atypical ANS development. We used eye-tracking to capture the PLR in 216 infants in a longitudinal follow-up study spanning 5 to 24 months of age, and linear mixed models to investigate effects of age and group on three PLR parameters: baseline pupil diameter, latency to constriction and relative constriction amplitude. An increase with age was found in baseline pupil diameter (F(3,273.21) = 13.15, p < 0.001, eta(2)(p) = 0.13), latency to constriction (F(3,326.41) =3.84, p = 0.010,eta(2)(p) = 0.03) and relative constriction amplitude(F(3,282.53) =3.70, p = 0.012,eta(2)(p)= 0.04). Group differences were found for baseline pupil diameter (F(3,235.91) = 9.40, p < 0.001,eta(2)(p) = 0.11), with larger diameter in preterms and siblings than in controls, and for latency to constriction (F(3,237.10) = 3.48, p = 0.017, eta(2)(p) = 0.04), with preterms having a longer latency than controls. The results align with previous evidence, with development over time that could be explained by ANS maturation. To better understand the cause of the group differences, further research in a larger sample is necessary, combining pupillometry with other measures to further validate its value.
Keywords
Preterm birth, Autism spectrum disorder, Autonomic nervous system, Infant development, Pupillometry

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MLA
de Vries, Lyssa M., et al. “Investigating the Development of the Autonomic Nervous System in Infancy through Pupillometry.” JOURNAL OF NEURAL TRANSMISSION, vol. 130, 2023, pp. 723–34, doi:10.1007/s00702-023-02616-7.
APA
de Vries, L. M., Amelynck, S., Nyström, P., van Esch, L., Van Lierde, T., Warreyn, P., … Team, T. (2023). Investigating the development of the autonomic nervous system in infancy through pupillometry. JOURNAL OF NEURAL TRANSMISSION, 130, 723–734. https://doi.org/10.1007/s00702-023-02616-7
Chicago author-date
Vries, Lyssa M. de, Steffie Amelynck, Pär Nyström, Lotte van Esch, Thijs Van Lierde, Petra Warreyn, Herbert Roeyers, et al. 2023. “Investigating the Development of the Autonomic Nervous System in Infancy through Pupillometry.” JOURNAL OF NEURAL TRANSMISSION 130: 723–34. https://doi.org/10.1007/s00702-023-02616-7.
Chicago author-date (all authors)
de Vries, Lyssa M., Steffie Amelynck, Pär Nyström, Lotte van Esch, Thijs Van Lierde, Petra Warreyn, Herbert Roeyers, Ilse Noens, Gunnar Naulaers, Bart Boets, Jean Steyaert, Floor Moerman, Maide Erdogan, and TIARA Team. 2023. “Investigating the Development of the Autonomic Nervous System in Infancy through Pupillometry.” JOURNAL OF NEURAL TRANSMISSION 130: 723–734. doi:10.1007/s00702-023-02616-7.
Vancouver
1.
de Vries LM, Amelynck S, Nyström P, van Esch L, Van Lierde T, Warreyn P, et al. Investigating the development of the autonomic nervous system in infancy through pupillometry. JOURNAL OF NEURAL TRANSMISSION. 2023;130:723–34.
IEEE
[1]
L. M. de Vries et al., “Investigating the development of the autonomic nervous system in infancy through pupillometry,” JOURNAL OF NEURAL TRANSMISSION, vol. 130, pp. 723–734, 2023.
@article{01GTE8DWDMAXG6GPK052710K74,
  abstract     = {{We aim to investigate early developmental trajectories of the autonomic nervous system (ANS) as indexed by the pupillary light reflex (PLR) in infants with (i.e. preterm birth, feeding difficulties, or siblings of children with autism spectrum disorder) and without (controls) increased likelihood for atypical ANS development. We used eye-tracking to capture the PLR in 216 infants in a longitudinal follow-up study spanning 5 to 24 months of age, and linear mixed models to investigate effects of age and group on three PLR parameters: baseline pupil diameter, latency to constriction and relative constriction amplitude. An increase with age was found in baseline pupil diameter (F(3,273.21) = 13.15, p < 0.001, eta(2)(p) = 0.13), latency to constriction (F(3,326.41) =3.84, p = 0.010,eta(2)(p) = 0.03) and relative constriction amplitude(F(3,282.53) =3.70, p = 0.012,eta(2)(p)= 0.04). Group differences were found for baseline pupil diameter (F(3,235.91) = 9.40, p < 0.001,eta(2)(p) = 0.11), with larger diameter in preterms and siblings than in controls, and for latency to constriction (F(3,237.10) = 3.48, p = 0.017, eta(2)(p) = 0.04), with preterms having a longer latency than controls. The results align with previous evidence, with development over time that could be explained by ANS maturation. To better understand the cause of the group differences, further research in a larger sample is necessary, combining pupillometry with other measures to further validate its value.}},
  author       = {{de Vries, Lyssa M. and Amelynck, Steffie and Nyström, Pär and van Esch, Lotte and Van Lierde, Thijs and Warreyn, Petra and Roeyers, Herbert and Noens, Ilse and Naulaers, Gunnar and Boets, Bart and Steyaert, Jean and Moerman, Floor and Erdogan, Maide and Team, TIARA}},
  issn         = {{0300-9564}},
  journal      = {{JOURNAL OF NEURAL TRANSMISSION}},
  keywords     = {{Preterm birth,Autism spectrum disorder,Autonomic nervous system,Infant development,Pupillometry}},
  language     = {{eng}},
  pages        = {{723--734}},
  title        = {{Investigating the development of the autonomic nervous system in infancy through pupillometry}},
  url          = {{http://doi.org/10.1007/s00702-023-02616-7}},
  volume       = {{130}},
  year         = {{2023}},
}
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