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Treatment response following adaptive PASAT training for depression vulnerability : a systematic review and meta-analysis

(2024) NEUROPSYCHOLOGY REVIEW. 34(1). p.232-249
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Abstract
In recent years, cognitive control training (CCT) has gained momentum as an intervention to remediate cognitive impairments and decrease depressive symptoms. One promising operationalization to train cognitive control is the adaptive Paced Auditory Serial Addition Task (aPASAT). In this systematic review and meta-analysis of aPASAT training, the efficacy of the intervention and potential moderators were examined. The PsycINFO, MEDLINE, Embase, Web of Science and Cochrane Library electronic databases were searched for studies examining aPASAT training for depressive symptomatology or rumination. Nineteen studies (n=1255) were included, comprising of depressed patients, remitted depressed patients, at-risk, and healthy participants. We found small significant effects directly after training for both depressive symptomatology and rumination, with similar effect sizes at followup. Subgroup analyses suggest a significantly higher mean effect of aPASAT training in nonhealthy populations for rumination immediately following training, but not for depressive symptomatology. The amount of training sessions did not moderate effects of CCT. aPASAT has a small but significant effect on depressive symptoms, with direct effects immediately after training, as well as sustained long-term effects. It is currently unclear how many sessions are required for sustained effects due to heterogeneity in training dosage and absence of sufficient trials. Our results suggest that aPASAT training may be most effective for at-risk, remitted- and clinically depressed populations. The effect sizes resulting from this metaanalysis could be used to adequately power future research, which could investigate a doseresponse relationship and examine potential treatment gains when combining CCT with other antidepressant interventions.
Keywords
Rumination, Cognitive remediation, Working memory training, Meta-analysis, Recurrence of depression, Depression, Cognitive control training, COGNITIVE CONTROL, MAJOR DEPRESSION, RUMINATION, INTERVENTION, STIMULATION, BIAS, RECOMMENDATIONS, HETEROGENEITY, PERSPECTIVE, REACTIVITY

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Citation

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MLA
Vander Zwalmen, Yannick, et al. “Treatment Response Following Adaptive PASAT Training for Depression Vulnerability : A Systematic Review and Meta-Analysis.” NEUROPSYCHOLOGY REVIEW, vol. 34, no. 1, 2024, pp. 232–49, doi:10.1007/s11065-023-09581-8.
APA
Vander Zwalmen, Y., Liebaert, E., Hoorelbeke, K., Nève de Mévergnies, C., Baeken, C., Verhaeghe, N., & Koster, E. (2024). Treatment response following adaptive PASAT training for depression vulnerability : a systematic review and meta-analysis. NEUROPSYCHOLOGY REVIEW, 34(1), 232–249. https://doi.org/10.1007/s11065-023-09581-8
Chicago author-date
Vander Zwalmen, Yannick, Eveline Liebaert, Kristof Hoorelbeke, Constance Nève de Mévergnies, Chris Baeken, Nick Verhaeghe, and Ernst Koster. 2024. “Treatment Response Following Adaptive PASAT Training for Depression Vulnerability : A Systematic Review and Meta-Analysis.” NEUROPSYCHOLOGY REVIEW 34 (1): 232–49. https://doi.org/10.1007/s11065-023-09581-8.
Chicago author-date (all authors)
Vander Zwalmen, Yannick, Eveline Liebaert, Kristof Hoorelbeke, Constance Nève de Mévergnies, Chris Baeken, Nick Verhaeghe, and Ernst Koster. 2024. “Treatment Response Following Adaptive PASAT Training for Depression Vulnerability : A Systematic Review and Meta-Analysis.” NEUROPSYCHOLOGY REVIEW 34 (1): 232–249. doi:10.1007/s11065-023-09581-8.
Vancouver
1.
Vander Zwalmen Y, Liebaert E, Hoorelbeke K, Nève de Mévergnies C, Baeken C, Verhaeghe N, et al. Treatment response following adaptive PASAT training for depression vulnerability : a systematic review and meta-analysis. NEUROPSYCHOLOGY REVIEW. 2024;34(1):232–49.
IEEE
[1]
Y. Vander Zwalmen et al., “Treatment response following adaptive PASAT training for depression vulnerability : a systematic review and meta-analysis,” NEUROPSYCHOLOGY REVIEW, vol. 34, no. 1, pp. 232–249, 2024.
@article{01GT96CJW02FQ903QMEJ61AYFH,
  abstract     = {{In recent years, cognitive control training (CCT) has gained momentum as an intervention to 
remediate cognitive impairments and decrease depressive symptoms. One promising 
operationalization to train cognitive control is the adaptive Paced Auditory Serial Addition Task 
(aPASAT). In this systematic review and meta-analysis of aPASAT training, the efficacy of the 
intervention and potential moderators were examined.

The PsycINFO, MEDLINE, Embase, Web of Science and Cochrane Library electronic 
databases were searched for studies examining aPASAT training for depressive 
symptomatology or rumination. 

Nineteen studies (n=1255) were included, comprising of depressed patients, remitted depressed 
patients, at-risk, and healthy participants. We found small significant effects directly after 
training for both depressive symptomatology and rumination, with similar effect sizes at followup. Subgroup analyses suggest a significantly higher mean effect of aPASAT training in nonhealthy populations for rumination immediately following training, but not for depressive 
symptomatology. The amount of training sessions did not moderate effects of CCT. 

aPASAT has a small but significant effect on depressive symptoms, with direct effects 
immediately after training, as well as sustained long-term effects. It is currently unclear how 
many sessions are required for sustained effects due to heterogeneity in training dosage and
absence of sufficient trials. Our results suggest that aPASAT training may be most effective for 
at-risk, remitted- and clinically depressed populations. The effect sizes resulting from this metaanalysis could be used to adequately power future research, which could investigate a doseresponse relationship and examine potential treatment gains when combining CCT with other 
antidepressant interventions.}},
  author       = {{Vander Zwalmen, Yannick and Liebaert, Eveline and Hoorelbeke, Kristof and Nève de Mévergnies, Constance and Baeken, Chris and Verhaeghe, Nick and Koster, Ernst}},
  issn         = {{1040-7308}},
  journal      = {{NEUROPSYCHOLOGY REVIEW}},
  keywords     = {{Rumination,Cognitive remediation,Working memory training,Meta-analysis,Recurrence of depression,Depression,Cognitive control training,COGNITIVE CONTROL,MAJOR DEPRESSION,RUMINATION,INTERVENTION,STIMULATION,BIAS,RECOMMENDATIONS,HETEROGENEITY,PERSPECTIVE,REACTIVITY}},
  language     = {{eng}},
  number       = {{1}},
  pages        = {{232--249}},
  title        = {{Treatment response following adaptive PASAT training for depression vulnerability : a systematic review and meta-analysis}},
  url          = {{http://doi.org/10.1007/s11065-023-09581-8}},
  volume       = {{34}},
  year         = {{2024}},
}

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