@article{01GT92YGJTYR60T0H75JE47VX9,
  abstract     = {{Context: In trans women, hormone treatment induces feminization; however, the degree of feminization varies from person to person. A possible contributing factor could be estrone, a weak estrogen that interferes with the estrogen receptor.

Objective: We assessed whether estrone is involved in feminization induced by hormone treatment.

Methods: This prospective cohort study, with follow-up of 1 year, included 212 adult trans women at a gender identity clinic, who were starting gender-affirming hormone treatment between July 2017 and December 2019, median age 25 years. Change in fat percentage and breast development were assessed.

Results: After 12 months of hormone treatment, estrone concentration was 187 pmol/L (95% CI, 153-220) in transdermal and 1516 pmol/L (95% CI, 1284-1748) in oral estradiol users. Fat percentage increased by 1.2% (interquartile range [IQR], 0.3-4.8) in transdermal and 4.6% (IQR, 2.5-5.9) in oral estradiol users. This was not associated with estrone concentrations in transdermal (+4.4% (95% CI, -4.0 to 13) per 100 pmol/L increase in estrone concentration) nor in oral estradiol users (-0.7% [95% CI, -1.7 to 0.3]). Breast volume increased by 69 mL (IQR, 58-134) in transdermal and 62 mL (IQR, 32-95) in oral estradiol users. This was not associated with estrone concentrations in transdermal (+14% [95% CI, -49 to 156] per 100 pmol/L increase in estrone concentration) nor oral estradiol users (+11% [95% CI -14 to 43]).

Conclusions: Change in fat percentage and breast development in trans women were not associated with estrone concentrations nor with administration route. Therefore, measurement of estrone concentrations does not have a place in the monitoring of feminization in trans women.}},
  author       = {{Tebbens, Marieke and  Heijboer, Annemieke C. and T'Sjoen, Guy and  Bisschop, Peter H. and  den Heijer, Martin}},
  issn         = {{0021-972X}},
  journal      = {{JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM}},
  keywords     = {{estrone/estradiol ratio,SHBG,breast volume,bioelectrical impedance analysis,estrone,gender-affirming hormone treatment}},
  language     = {{eng}},
  number       = {{2}},
  pages        = {{E458--E466}},
  title        = {{The role of estrone in feminizing hormone treatment}},
  url          = {{http://doi.org/10.1210/clinem/dgab741}},
  volume       = {{107}},
  year         = {{2022}},
}

Altmetric

View in Altmetric

Web of Science

Times cited: