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Overcoming inter-observer planning variability in target volume contouring and dose planning for high-risk neuroblastoma : a European multicenter effort of the SIOPEN Radiotherapy Committee

Danny Jazmati, Lorenzo Brualla, Annemieke S Littooij, Britta Webber, Karin Dieckmann, Geert O Janssens, Thorsten Simon, Mark N. Gaze, Julien Merta, Antonio Serrano, et al.
(2023) RADIOTHERAPY AND ONCOLOGY. 181.
Author
Organization
Abstract
Background and purpose: To establish an international quality standard for contouring and planning for high-risk neuroblastoma within the prospective High-Risk Neuroblastoma Study 2 of SIOP-Europe-Neuroblastoma (SIOPEN HR-NBL2), which includes a randomized question on dose escalation for residual disease. Materials and methods: Data on four patients with high-risk neuroblastoma were selected and distributed to the radiotherapy committee of the HR-NBL2 study for independent contouring and planning. Differences in contouring were analyzed using apparent and kappa-corrected agreement. Plans were ana-lyzed regarding the dose-volume histogram metrics. Results were discussed among experts and agree-ment was obtained.Results: Substantial agreement was found for contouring of the heart (0.64), liver (0.70), left lung (0.74), and right lung (0.74). For contouring of the gastrointestinal tract (0.54), left kidney (0.60), and right kid-ney (0.59) moderate agreement was obtained. For target volume delineation, agreement for preoperative tumour extent was moderate (0.42), for CTV fair (0.35) and only low (0.06) for residual tumour, respec-tively. The dose planning strategies appeared to be relatively homogeneous among all experts.Conclusion: Considerable variability was found for the delineation of target volumes, particularly the boost volume, whereas the contouring of the organs at risk and the planning strategy were reasonably consistent. In order to obtain reliable results from the randomized HR-NBL2 trial, standardization of tar-get volume delineation based on adequate imaging is crucial.(c) 2023 Published by Elsevier B.V. Radiotherapy and Oncology 181 (2023) 109464
Keywords
Radiology, Nuclear Medicine and imaging, Oncology, Hematology, Guideline, Childhood cancer, SIOPEN, Neuroblastoma

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MLA
Jazmati, Danny, et al. “Overcoming Inter-Observer Planning Variability in Target Volume Contouring and Dose Planning for High-Risk Neuroblastoma : A European Multicenter Effort of the SIOPEN Radiotherapy Committee.” RADIOTHERAPY AND ONCOLOGY, vol. 181, Elsevier BV, 2023, doi:10.1016/j.radonc.2023.109464.
APA
Jazmati, D., Brualla, L., Littooij, A. S., Webber, B., Dieckmann, K., Janssens, G. O., … Timmermann, B. (2023). Overcoming inter-observer planning variability in target volume contouring and dose planning for high-risk neuroblastoma : a European multicenter effort of the SIOPEN Radiotherapy Committee. RADIOTHERAPY AND ONCOLOGY, 181. https://doi.org/10.1016/j.radonc.2023.109464
Chicago author-date
Jazmati, Danny, Lorenzo Brualla, Annemieke S Littooij, Britta Webber, Karin Dieckmann, Geert O Janssens, Thorsten Simon, et al. 2023. “Overcoming Inter-Observer Planning Variability in Target Volume Contouring and Dose Planning for High-Risk Neuroblastoma : A European Multicenter Effort of the SIOPEN Radiotherapy Committee.” RADIOTHERAPY AND ONCOLOGY 181. https://doi.org/10.1016/j.radonc.2023.109464.
Chicago author-date (all authors)
Jazmati, Danny, Lorenzo Brualla, Annemieke S Littooij, Britta Webber, Karin Dieckmann, Geert O Janssens, Thorsten Simon, Mark N. Gaze, Julien Merta, Antonio Serrano, Stefan Dietzsch, Paul-Heinz Kramer, Jörg Wulff, Tom Boterberg, and Beate Timmermann. 2023. “Overcoming Inter-Observer Planning Variability in Target Volume Contouring and Dose Planning for High-Risk Neuroblastoma : A European Multicenter Effort of the SIOPEN Radiotherapy Committee.” RADIOTHERAPY AND ONCOLOGY 181. doi:10.1016/j.radonc.2023.109464.
Vancouver
1.
Jazmati D, Brualla L, Littooij AS, Webber B, Dieckmann K, Janssens GO, et al. Overcoming inter-observer planning variability in target volume contouring and dose planning for high-risk neuroblastoma : a European multicenter effort of the SIOPEN Radiotherapy Committee. RADIOTHERAPY AND ONCOLOGY. 2023;181.
IEEE
[1]
D. Jazmati et al., “Overcoming inter-observer planning variability in target volume contouring and dose planning for high-risk neuroblastoma : a European multicenter effort of the SIOPEN Radiotherapy Committee,” RADIOTHERAPY AND ONCOLOGY, vol. 181, 2023.
@article{01GSWYP4S7X5TDAFGQE1WMYJT7,
  abstract     = {{Background and purpose: To establish an international quality standard for contouring and planning for high-risk neuroblastoma within the prospective High-Risk Neuroblastoma Study 2 of SIOP-Europe-Neuroblastoma (SIOPEN HR-NBL2), which includes a randomized question on dose escalation for residual disease. Materials and methods: Data on four patients with high-risk neuroblastoma were selected and distributed to the radiotherapy committee of the HR-NBL2 study for independent contouring and planning. Differences in contouring were analyzed using apparent and kappa-corrected agreement. Plans were ana-lyzed regarding the dose-volume histogram metrics. Results were discussed among experts and agree-ment was obtained.Results: Substantial agreement was found for contouring of the heart (0.64), liver (0.70), left lung (0.74), and right lung (0.74). For contouring of the gastrointestinal tract (0.54), left kidney (0.60), and right kid-ney (0.59) moderate agreement was obtained. For target volume delineation, agreement for preoperative tumour extent was moderate (0.42), for CTV fair (0.35) and only low (0.06) for residual tumour, respec-tively. The dose planning strategies appeared to be relatively homogeneous among all experts.Conclusion: Considerable variability was found for the delineation of target volumes, particularly the boost volume, whereas the contouring of the organs at risk and the planning strategy were reasonably consistent. In order to obtain reliable results from the randomized HR-NBL2 trial, standardization of tar-get volume delineation based on adequate imaging is crucial.(c) 2023 Published by Elsevier B.V. Radiotherapy and Oncology 181 (2023) 109464}},
  articleno    = {{109464}},
  author       = {{Jazmati, Danny and Brualla, Lorenzo and Littooij, Annemieke S and Webber, Britta and Dieckmann, Karin and Janssens, Geert O and Simon, Thorsten and Gaze, Mark N. and Merta, Julien and Serrano, Antonio and Dietzsch, Stefan and Kramer, Paul-Heinz and Wulff, Jörg and Boterberg, Tom and Timmermann, Beate}},
  issn         = {{0167-8140}},
  journal      = {{RADIOTHERAPY AND ONCOLOGY}},
  keywords     = {{Radiology, Nuclear Medicine and imaging,Oncology,Hematology,Guideline,Childhood cancer,SIOPEN,Neuroblastoma}},
  language     = {{eng}},
  pages        = {{8}},
  publisher    = {{Elsevier BV}},
  title        = {{Overcoming inter-observer planning variability in target volume contouring and dose planning for high-risk neuroblastoma : a European multicenter effort of the SIOPEN Radiotherapy Committee}},
  url          = {{http://doi.org/10.1016/j.radonc.2023.109464}},
  volume       = {{181}},
  year         = {{2023}},
}
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