@article{01GSA3TCNNBEGMM6V29JTV82NP,
  abstract     = {{Introduction: Previous studies showed that healthcare professionals and patients had only moderate to low agreement on their assessment of treatment-related symptoms. We aimed to determine the levels of agreement in a large cohort of prostate cancer patients. Methods: Analyses were made of data from 1,756 prostate cancer patients treated with external beam radiotherapy (RT) and/or brachytherapy in Europe and the USA and recruited into the prospective mul-ticentre observational REQUITE study. Eleven pelvic symptoms at the end of RT were compared after translating patient-reported outcomes (PROs) into CTCAE-based healthcare professional ratings. Gwet's AC2 agreement coefficient and 95% confidence intervals were calculated for each symptom. To compare severity of grading between patients and healthcare professionals, percent agreement and deviations for each symptom were graphically depicted. Stratified and sensitivity analyses were conducted to identify potential influencing factors and to assess heterogeneity and robustness of results.Results: The agreement for the 11 pelvic symptoms varied from very good (AC2 > 0.8: haematuria, rectal bleeding, management of sphincter control) to poor agreement (AC2 <= 0.2: proctitis and urinary urgency). Fatigue had a negative impact on the agreement. Patients tended to grade symptoms more severely than healthcare professionals. Information on sexual dysfunction was missing more frequently in healthcare professional assessment than PROs. Conclusion: Agreement was better for observable than subjective symptoms, with patients usually grad-ing symptoms more severely than healthcare professionals. Our findings emphasize that PROs should complement symptom assessment by healthcare professionals and be taken into consideration for clin-ical decision-making to incorporate the patient perspective.(c) 2022 The Authors. Published by Elsevier B.V. Radiotherapy and Oncology 176 (2022) 109426 This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).}},
  articleno    = {{109426}},
  author       = {{Heumann, Philipp and Aguado-Barrera, Miguel E. and Avuzzi, Barbara and Azria, David and Briers, Erik and Bultijnck, Renée and Choudhury, Ananya and De Ruysscher, Dirk and Farcy-Jacquet, Marie-Pierre and Fonteyne, Valerie and Gómez Caamaño, Antonio and Helmbold, Irmgard and Johnson, Kerstie and Kerns, Sarah L. and Lambrecht, Maarten and Lingard, Zoe and Rancati, Tiziana and Rosenstein, Barry S. and Sperk, Elena and Paul Symonds, R. and Talbot, Christopher and Valdagni, Riccardo and Vega, Ana and Veldeman, Liv and Ward, Tim and Webb, Adam and West, Catharine M. and Chang-Claude, Jenny and Seibold, Petra}},
  issn         = {{0167-8140}},
  journal      = {{RADIOTHERAPY AND ONCOLOGY}},
  keywords     = {{Radiology, Nuclear Medicine and imaging,Oncology,Hematology,Radiotherapy,Prostate cancer,Patient -reported outcomes,Adverse events,Agreement}},
  language     = {{eng}},
  pages        = {{10}},
  publisher    = {{Elsevier BV}},
  title        = {{Comparing symptom reporting by prostate cancer patients and healthcare professionals in the international multicentre REQUITE study}},
  url          = {{http://doi.org/10.1016/j.radonc.2022.11.015}},
  volume       = {{178}},
  year         = {{2023}},
}

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