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Mechanisms controlling plant proteases and their substrates

(2023) CELL DEATH AND DIFFERENTIATION. 30(4). p.1047-1058
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Abstract
In plants, proteolysis is emerging as an important field of study due to a growing understanding of the critical involvement of proteases in plant cell death, disease and development. Because proteases irreversibly modify the structure and function of their target substrates, proteolytic activities are stringently regulated at multiple levels. Most proteases are produced as dormant isoforms and only activated in specific conditions such as altered ion fluxes or by post-translational modifications. Some of the regulatory mechanisms initiating and modulating proteolytic activities are restricted in time and space, thereby ensuring precision activity, and minimizing unwanted side effects. Currently, the activation mechanisms and the substrates of only a few plant proteases have been studied in detail. Most studies focus on the role of proteases in pathogen perception and subsequent modulation of the plant reactions, including the hypersensitive response (HR). Proteases are also required for the maturation of coexpressed peptide hormones that lead essential processes within the immune response and development. Here, we review the known mechanisms for the activation of plant proteases, including post-translational modifications, together with the effects of proteinaceous inhibitors.
Keywords
Cell Biology, Molecular Biology, FLORAL ORGAN ABSCISSION, UBIQUITIN-LIKE ATG8, CELL-DEATH, ARABIDOPSIS-THALIANA, DISEASE RESISTANCE, CRYSTAL-STRUCTURE, EFFECTOR AVRRPT2, SERINE-PROTEASE, PEPTIDE-HORMONE, METACASPASES

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Citation

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MLA
Fernández Fernández, Álvaro Daniel, et al. “Mechanisms Controlling Plant Proteases and Their Substrates.” CELL DEATH AND DIFFERENTIATION, vol. 30, no. 4, Springernature, 2023, pp. 1047–58, doi:10.1038/s41418-023-01120-5.
APA
Fernández Fernández, Á. D., Stael, S., & Van Breusegem, F. (2023). Mechanisms controlling plant proteases and their substrates. CELL DEATH AND DIFFERENTIATION, 30(4), 1047–1058. https://doi.org/10.1038/s41418-023-01120-5
Chicago author-date
Fernández Fernández, Álvaro Daniel, Simon Stael, and Frank Van Breusegem. 2023. “Mechanisms Controlling Plant Proteases and Their Substrates.” CELL DEATH AND DIFFERENTIATION 30 (4): 1047–58. https://doi.org/10.1038/s41418-023-01120-5.
Chicago author-date (all authors)
Fernández Fernández, Álvaro Daniel, Simon Stael, and Frank Van Breusegem. 2023. “Mechanisms Controlling Plant Proteases and Their Substrates.” CELL DEATH AND DIFFERENTIATION 30 (4): 1047–1058. doi:10.1038/s41418-023-01120-5.
Vancouver
1.
Fernández Fernández ÁD, Stael S, Van Breusegem F. Mechanisms controlling plant proteases and their substrates. CELL DEATH AND DIFFERENTIATION. 2023;30(4):1047–58.
IEEE
[1]
Á. D. Fernández Fernández, S. Stael, and F. Van Breusegem, “Mechanisms controlling plant proteases and their substrates,” CELL DEATH AND DIFFERENTIATION, vol. 30, no. 4, pp. 1047–1058, 2023.
@article{01GS7YB3G9DKTBM45CKHZPHDQA,
  abstract     = {{In plants, proteolysis is emerging as an important field of study due to a growing understanding of the critical involvement of proteases in plant cell death, disease and development. Because proteases irreversibly modify the structure and function of their target substrates, proteolytic activities are stringently regulated at multiple levels. Most proteases are produced as dormant isoforms and only activated in specific conditions such as altered ion fluxes or by post-translational modifications. Some of the regulatory mechanisms initiating and modulating proteolytic activities are restricted in time and space, thereby ensuring precision activity, and minimizing unwanted side effects. Currently, the activation mechanisms and the substrates of only a few plant proteases have been studied in detail. Most studies focus on the role of proteases in pathogen perception and subsequent modulation of the plant reactions, including the hypersensitive response (HR). Proteases are also required for the maturation of coexpressed peptide hormones that lead essential processes within the immune response and development. Here, we review the known mechanisms for the activation of plant proteases, including post-translational modifications, together with the effects of proteinaceous inhibitors.}},
  author       = {{Fernández Fernández, Álvaro Daniel and Stael, Simon and Van Breusegem, Frank}},
  issn         = {{1350-9047}},
  journal      = {{CELL DEATH AND DIFFERENTIATION}},
  keywords     = {{Cell Biology,Molecular Biology,FLORAL ORGAN ABSCISSION,UBIQUITIN-LIKE ATG8,CELL-DEATH,ARABIDOPSIS-THALIANA,DISEASE RESISTANCE,CRYSTAL-STRUCTURE,EFFECTOR AVRRPT2,SERINE-PROTEASE,PEPTIDE-HORMONE,METACASPASES}},
  language     = {{eng}},
  number       = {{4}},
  pages        = {{1047--1058}},
  publisher    = {{Springernature}},
  title        = {{Mechanisms controlling plant proteases and their substrates}},
  url          = {{http://doi.org/10.1038/s41418-023-01120-5}},
  volume       = {{30}},
  year         = {{2023}},
}

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