@article{01GS7KNJPP3ZS0FYWSQTZTCXGY,
  abstract     = {{Visualization of the dynamic behavior of pharmaceutical dosage forms during the dissolution process offers a better understanding of the drug release mechanism, enabling the design of customized dosage forms. In this study, an X-ray tomography-based approach is proposed to monitor and analyze the dynamics of the structure at the pore scale level during the dissolution process. A flow-through cell dissolution apparatus was developed, capable of mimicking the standard in vitro dissolution process, which can be easily positioned in an X-ray tomography setup. The method was utilized to study the dissolution of a Capa® (polycaprolactone)-based sustained-release 3D printed tablet. The impact of the flow rate on the active pharmaceutical ingredient (API) release rate was studied and 16 mL/min was selected as a suitable flow rate. Furthermore, cesium chloride (CsCl) was used as a contrast agent to increase the contrast between the sample and the dissolution medium. Data obtained with this novel technique were in a good agreement with the released drug rate acquired by the standard in vitro dissolution test (the similarity factor f(2) = 77%). Finally, the proposed approach allowed visualizing the internal structure of the sample, as well as real-time tracking of solution ingress into the product.}},
  articleno    = {{2475}},
  author       = {{Moazami Goudarzi, Niloofar and Samaro, Aseel and Vervaet, Chris and Boone, Matthieu}},
  issn         = {{1999-4923}},
  journal      = {{PHARMACEUTICS}},
  keywords     = {{dissolution,μCT,flow-through cell method,contrast agent,3D  printing,sustained release,mu CT,3D printing,MAGNETIC-RESONANCE MICROSCOPY,CONTROLLED-RELEASE,DRUG DISSOLUTION,MORPHOLOGICAL-CHANGES,COMPUTED-TOMOGRAPHY,DENSITY VARIATIONS,TABLETS,MATRIX,QUANTIFICATION,SPECTROSCOPY}},
  language     = {{eng}},
  number       = {{11}},
  pages        = {{16}},
  title        = {{Development of flow-through cell dissolution method for in situ visualization of dissolution processes in solid dosage forms using X-ray μCT}},
  url          = {{http://doi.org/10.3390/pharmaceutics14112475}},
  volume       = {{14}},
  year         = {{2022}},
}

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