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Cell behavior changes and enzymatic biodegradation of hybrid electrospun poly(3-hydroxybutyrate)-based scaffolds with an enhanced piezoresponse after the addition of reduced graphene oxide

Roman Chernozem, Igor Pariy, Maria A. A. Surmeneva, Vladimir V. V. Shvartsman, Guillaume Planckaert (UGent) , Joost Verduijn (UGent) , Stef Ghysels (UGent) , Anatolii Abalymov, Bogdan Parakhonskiy (UGent) , Eric Gracey (UGent) , et al.
(2023) ADVANCED HEALTHCARE MATERIALS. 12(8).
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Abstract
This is the first comprehensive study of the impact of biodegradation on the structure, surface potential, mechanical and piezoelectric properties of poly(3-hydroxybutyrate) (PHB) scaffolds supplemented with reduced graphene oxide (rGO) as well as cell behavior under static and dynamic mechanical conditions. There is no effect of the rGO addition up to 1.0 wt% on the rate of enzymatic biodegradation of PHB scaffolds for 30 d. The biodegradation of scaffolds leads to the depolymerization of the amorphous phase, resulting in an increase in the degree of crystallinity. Because of more regular dipole order in the crystalline phase, surface potential of all fibers increases after the biodegradation, with a maximum (361 +/- 5 mV) after the addition of 1 wt% rGO into PHB as compared to pristine PHB fibers. By contrast, PHB-0.7rGO fibers manifest the strongest effective vertical (0.59 +/- 0.03 pm V-1) and lateral (1.06 +/- 0.02 pm V-1) piezoresponse owing to a greater presence of electroactive beta-phase. In vitro assays involving primary human fibroblasts reveal equal biocompatibility and faster cell proliferation on PHB-0.7rGO scaffolds compared to pure PHB and nonpiezoelectric polycaprolactone scaffolds. Thus, the developed biodegradable PHB-rGO scaffolds with enhanced piezoresponse are promising for tissue-engineering applications.
Keywords
biodegradation, piezoelectric, poly(3-hydroxybutyrate), reduced graphene, oxide, tissue engineering, PLASMA TREATMENT, PIEZOELECTRIC PROPERTIES, TISSUE REGENERATION, BONE, DEGRADATION, COPOLYMERS, MORPHOLOGY, POLYMERS, SURFACES, BLENDS

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Citation

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MLA
Chernozem, Roman, et al. “Cell Behavior Changes and Enzymatic Biodegradation of Hybrid Electrospun Poly(3-Hydroxybutyrate)-Based Scaffolds with an Enhanced Piezoresponse after the Addition of Reduced Graphene Oxide.” ADVANCED HEALTHCARE MATERIALS, vol. 12, no. 8, 2023, doi:10.1002/adhm.202201726.
APA
Chernozem, R., Pariy, I., Surmeneva, M. A. A., Shvartsman, V. V. V., Planckaert, G., Verduijn, J., … Skirtach, A. (2023). Cell behavior changes and enzymatic biodegradation of hybrid electrospun poly(3-hydroxybutyrate)-based scaffolds with an enhanced piezoresponse after the addition of reduced graphene oxide. ADVANCED HEALTHCARE MATERIALS, 12(8). https://doi.org/10.1002/adhm.202201726
Chicago author-date
Chernozem, Roman, Igor Pariy, Maria A. A. Surmeneva, Vladimir V. V. Shvartsman, Guillaume Planckaert, Joost Verduijn, Stef Ghysels, et al. 2023. “Cell Behavior Changes and Enzymatic Biodegradation of Hybrid Electrospun Poly(3-Hydroxybutyrate)-Based Scaffolds with an Enhanced Piezoresponse after the Addition of Reduced Graphene Oxide.” ADVANCED HEALTHCARE MATERIALS 12 (8). https://doi.org/10.1002/adhm.202201726.
Chicago author-date (all authors)
Chernozem, Roman, Igor Pariy, Maria A. A. Surmeneva, Vladimir V. V. Shvartsman, Guillaume Planckaert, Joost Verduijn, Stef Ghysels, Anatolii Abalymov, Bogdan Parakhonskiy, Eric Gracey, Amanda Gonçalves, Sanjay Mathur, Frederik Ronsse, Diederik Depla, Doru C. C. Lupascu, Dirk Elewaut, Roman A. A. Surmenev, and Andre Skirtach. 2023. “Cell Behavior Changes and Enzymatic Biodegradation of Hybrid Electrospun Poly(3-Hydroxybutyrate)-Based Scaffolds with an Enhanced Piezoresponse after the Addition of Reduced Graphene Oxide.” ADVANCED HEALTHCARE MATERIALS 12 (8). doi:10.1002/adhm.202201726.
Vancouver
1.
Chernozem R, Pariy I, Surmeneva MAA, Shvartsman VVV, Planckaert G, Verduijn J, et al. Cell behavior changes and enzymatic biodegradation of hybrid electrospun poly(3-hydroxybutyrate)-based scaffolds with an enhanced piezoresponse after the addition of reduced graphene oxide. ADVANCED HEALTHCARE MATERIALS. 2023;12(8).
IEEE
[1]
R. Chernozem et al., “Cell behavior changes and enzymatic biodegradation of hybrid electrospun poly(3-hydroxybutyrate)-based scaffolds with an enhanced piezoresponse after the addition of reduced graphene oxide,” ADVANCED HEALTHCARE MATERIALS, vol. 12, no. 8, 2023.
@article{01GS7GNKA5Z6EVCVR9ES5NZH4G,
  abstract     = {{This is the first comprehensive study of the impact of biodegradation on the structure, surface potential, mechanical and piezoelectric properties of poly(3-hydroxybutyrate) (PHB) scaffolds supplemented with reduced graphene oxide (rGO) as well as cell behavior under static and dynamic mechanical conditions. There is no effect of the rGO addition up to 1.0 wt% on the rate of enzymatic biodegradation of PHB scaffolds for 30 d. The biodegradation of scaffolds leads to the depolymerization of the amorphous phase, resulting in an increase in the degree of crystallinity. Because of more regular dipole order in the crystalline phase, surface potential of all fibers increases after the biodegradation, with a maximum (361 +/- 5 mV) after the addition of 1 wt% rGO into PHB as compared to pristine PHB fibers. By contrast, PHB-0.7rGO fibers manifest the strongest effective vertical (0.59 +/- 0.03 pm V-1) and lateral (1.06 +/- 0.02 pm V-1) piezoresponse owing to a greater presence of electroactive beta-phase. In vitro assays involving primary human fibroblasts reveal equal biocompatibility and faster cell proliferation on PHB-0.7rGO scaffolds compared to pure PHB and nonpiezoelectric polycaprolactone scaffolds. Thus, the developed biodegradable PHB-rGO scaffolds with enhanced piezoresponse are promising for tissue-engineering applications.}},
  articleno    = {{2201726}},
  author       = {{Chernozem, Roman and  Pariy, Igor and  Surmeneva, Maria A. A. and  Shvartsman, Vladimir V. V. and Planckaert, Guillaume and Verduijn, Joost and Ghysels, Stef and  Abalymov, Anatolii and Parakhonskiy, Bogdan and Gracey, Eric and Gonçalves, Amanda and  Mathur, Sanjay and Ronsse, Frederik and Depla, Diederik and  Lupascu, Doru C. C. and Elewaut, Dirk and  Surmenev, Roman A. A. and Skirtach, Andre}},
  issn         = {{2192-2640}},
  journal      = {{ADVANCED HEALTHCARE MATERIALS}},
  keywords     = {{biodegradation,piezoelectric,poly(3-hydroxybutyrate),reduced graphene,oxide,tissue engineering,PLASMA TREATMENT,PIEZOELECTRIC PROPERTIES,TISSUE REGENERATION,BONE,DEGRADATION,COPOLYMERS,MORPHOLOGY,POLYMERS,SURFACES,BLENDS}},
  language     = {{eng}},
  number       = {{8}},
  pages        = {{18}},
  title        = {{Cell behavior changes and enzymatic biodegradation of hybrid electrospun poly(3-hydroxybutyrate)-based scaffolds with an enhanced piezoresponse after the addition of reduced graphene oxide}},
  url          = {{http://doi.org/10.1002/adhm.202201726}},
  volume       = {{12}},
  year         = {{2023}},
}
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