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Retrospective real-life study on preoperative imaging for minimally invasive parathyroidectomy in primary hyperparathyroidism

Jacqueline Bijnens, Annick Van den Bruel, Vincent Vander Poorten, Ingeborg Goethals (UGent) , Steven Van Schandevyl, Catherine Dick and Frank De Geeter
(2022) SCIENTIFIC REPORTS. 12(1).
Author
Organization
Abstract
The objective of this study was to retrospectively evaluate preoperative imaging modalities for localization of parathyroid adenomas with a view to enable minimally invasive parathyroidectomy and in particular, to consider the contribution of F-18-fluorocholine-PET/CT. 104 patients with primary hyperparathyroidism, who underwent parathyroid surgery in a single centre during a 6-year period were included. Of these, 103 underwent ultrasound, 97 Tc-99m-Pertechnetate/SestaMIBI-SPECT, 20 MRI and 30 F-18-fluorocholine-PET/CT. Based on surgical findings, sensitivities and specificities for correct lateralisation in orthotopic locations were: for ultrasound 0.75 (0.65-0.83) and 0.89 (0.81-0.94), for Tc-99m-MIBI-SPECT 0.57 (0.46-0.67) and 0.97 (0.91-0.99), for MRI 0.60 (0.36-0.81) and 0.83 (0.59-0.96) and for F-18-fluorocholine-PET/CT 0.90 (0.73-0.98) and 0.90 (0.73-0.98). Correctly lateralized adenomas were significantly larger than those not found with ultrasound (p = 0.03) and SPECT (p = 0.002). Pre-operative PTH-levels were higher in single adenomas detected by scintigraphy than in those not (p = 0.02). 64 patients could be treated with a minimally invasive procedure. Cure after parathyroidectomy was obtained in 94% of patients. F-18-Fluorocholine-PET/CT could be shown to be a highly accurate modality to localize parathyroid adenomas preoperatively, obviating the need for total exploration in the majority of patients in whom ultrasound and scintigraphic results are discordant or both negative.
Keywords
Multidisciplinary

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MLA
Bijnens, Jacqueline, et al. “Retrospective Real-Life Study on Preoperative Imaging for Minimally Invasive Parathyroidectomy in Primary Hyperparathyroidism.” SCIENTIFIC REPORTS, vol. 12, no. 1, Springer Science and Business Media LLC, 2022, doi:10.1038/s41598-022-18219-3.
APA
Bijnens, J., Van den Bruel, A., Vander Poorten, V., Goethals, I., Van Schandevyl, S., Dick, C., & De Geeter, F. (2022). Retrospective real-life study on preoperative imaging for minimally invasive parathyroidectomy in primary hyperparathyroidism. SCIENTIFIC REPORTS, 12(1). https://doi.org/10.1038/s41598-022-18219-3
Chicago author-date
Bijnens, Jacqueline, Annick Van den Bruel, Vincent Vander Poorten, Ingeborg Goethals, Steven Van Schandevyl, Catherine Dick, and Frank De Geeter. 2022. “Retrospective Real-Life Study on Preoperative Imaging for Minimally Invasive Parathyroidectomy in Primary Hyperparathyroidism.” SCIENTIFIC REPORTS 12 (1). https://doi.org/10.1038/s41598-022-18219-3.
Chicago author-date (all authors)
Bijnens, Jacqueline, Annick Van den Bruel, Vincent Vander Poorten, Ingeborg Goethals, Steven Van Schandevyl, Catherine Dick, and Frank De Geeter. 2022. “Retrospective Real-Life Study on Preoperative Imaging for Minimally Invasive Parathyroidectomy in Primary Hyperparathyroidism.” SCIENTIFIC REPORTS 12 (1). doi:10.1038/s41598-022-18219-3.
Vancouver
1.
Bijnens J, Van den Bruel A, Vander Poorten V, Goethals I, Van Schandevyl S, Dick C, et al. Retrospective real-life study on preoperative imaging for minimally invasive parathyroidectomy in primary hyperparathyroidism. SCIENTIFIC REPORTS. 2022;12(1).
IEEE
[1]
J. Bijnens et al., “Retrospective real-life study on preoperative imaging for minimally invasive parathyroidectomy in primary hyperparathyroidism,” SCIENTIFIC REPORTS, vol. 12, no. 1, 2022.
@article{01GS54ZWGJXYZYW9Q6DAQ529YM,
  abstract     = {{The objective of this study was to retrospectively evaluate preoperative imaging modalities for localization of parathyroid adenomas with a view to enable minimally invasive parathyroidectomy and in particular, to consider the contribution of F-18-fluorocholine-PET/CT. 104 patients with primary hyperparathyroidism, who underwent parathyroid surgery in a single centre during a 6-year period were included. Of these, 103 underwent ultrasound, 97 Tc-99m-Pertechnetate/SestaMIBI-SPECT, 20 MRI and 30 F-18-fluorocholine-PET/CT. Based on surgical findings, sensitivities and specificities for correct lateralisation in orthotopic locations were: for ultrasound 0.75 (0.65-0.83) and 0.89 (0.81-0.94), for Tc-99m-MIBI-SPECT 0.57 (0.46-0.67) and 0.97 (0.91-0.99), for MRI 0.60 (0.36-0.81) and 0.83 (0.59-0.96) and for F-18-fluorocholine-PET/CT 0.90 (0.73-0.98) and 0.90 (0.73-0.98). Correctly lateralized adenomas were significantly larger than those not found with ultrasound (p = 0.03) and SPECT (p = 0.002). Pre-operative PTH-levels were higher in single adenomas detected by scintigraphy than in those not (p = 0.02). 64 patients could be treated with a minimally invasive procedure. Cure after parathyroidectomy was obtained in 94% of patients. F-18-Fluorocholine-PET/CT could be shown to be a highly accurate modality to localize parathyroid adenomas preoperatively, obviating the need for total exploration in the majority of patients in whom ultrasound and scintigraphic results are discordant or both negative.}},
  articleno    = {{17427}},
  author       = {{Bijnens, Jacqueline and Van den Bruel, Annick and Vander Poorten, Vincent and Goethals, Ingeborg and Van Schandevyl, Steven and Dick, Catherine and De Geeter, Frank}},
  issn         = {{2045-2322}},
  journal      = {{SCIENTIFIC REPORTS}},
  keywords     = {{Multidisciplinary}},
  language     = {{eng}},
  number       = {{1}},
  pages        = {{8}},
  publisher    = {{Springer Science and Business Media LLC}},
  title        = {{Retrospective real-life study on preoperative imaging for minimally invasive parathyroidectomy in primary hyperparathyroidism}},
  url          = {{http://doi.org/10.1038/s41598-022-18219-3}},
  volume       = {{12}},
  year         = {{2022}},
}
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