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MRI texture analysis of T2-weighted images is preferred over magnetization transfer imaging for readily longitudinal quantification of gut fibrosis

Isabelle De Kock (UGent) , Simon Bos (UGent) , Louke Delrue (UGent) , Sophie Van Welden (UGent) , Peter Bunyard, Pieter Hindryckx (UGent) , Martine De Vos (UGent) , Geert Villeirs (UGent) and Debby Laukens (UGent)
(2023) EUROPEAN RADIOLOGY. 33(9). p.5943-5952
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Abstract
ObjectivesTo investigate the value of magnetization transfer (MT) MRI and texture analysis (TA) of T2-weighted MR images (T2WI) in the assessment of intestinal fibrosis in a mouse model.MethodsChronic colitis was induced in mice by cyclic administration of dextran sodium sulphate (DSS) resulting in chronic inflammation and progressive bowel fibrosis. Mice underwent 7-T MR imaging at various time points. Bowel wall MT ratio (MTR) and textural features (skewness, kurtosis, entropy), extracted by a filtration histogram technique, were correlated with histopathology. Performance of both techniques were validated using antifibrotic therapy. Finally, a retrospective study was conducted in five patients with Crohn's disease (CD) who underwent bowel surgery.ResultsMTR and texture entropy correlated with histopathological fibrosis (r = .85 and .81, respectively). Entropy was superior to MTR for monitoring bowel fibrosis in the presence of coexisting inflammation (linear regression R-2 = .93 versus R-2 = .01). Furthermore, texture entropy was able to assess antifibrotic therapy response (placebo mice versus treated mice at endpoint scan; Delta mean = 0.128, p < .0001). An increase in entropy was indicative of fibrosis accumulation in human CD strictures (inflammation: 1.29; mixed strictures: 1.4 and 1.48; fibrosis: 1.73 and 1.9).ConclusionMT imaging and TA of T2WI can both noninvasively detect established intestinal fibrosis in a mouse model. However, TA is especially useful for the longitudinal quantification of fibrosis in mixed inflammatory-fibrotic tissue, as well as for antifibrotic treatment response evaluation. This accessible post-processing technique merits further validation as the benefits for clinical practice as well as antifibrotic trial design would be numerous.
Keywords
Entropy, Fibrosis, Inflammation, Colitis, Magnetic resonance imaging

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MLA
De Kock, Isabelle, et al. “MRI Texture Analysis of T2-Weighted Images Is Preferred over Magnetization Transfer Imaging for Readily Longitudinal Quantification of Gut Fibrosis.” EUROPEAN RADIOLOGY, vol. 33, no. 9, 2023, pp. 5943–52, doi:10.1007/s00330-023-09624-x.
APA
De Kock, I., Bos, S., Delrue, L., Van Welden, S., Bunyard, P., Hindryckx, P., … Laukens, D. (2023). MRI texture analysis of T2-weighted images is preferred over magnetization transfer imaging for readily longitudinal quantification of gut fibrosis. EUROPEAN RADIOLOGY, 33(9), 5943–5952. https://doi.org/10.1007/s00330-023-09624-x
Chicago author-date
De Kock, Isabelle, Simon Bos, Louke Delrue, Sophie Van Welden, Peter Bunyard, Pieter Hindryckx, Martine De Vos, Geert Villeirs, and Debby Laukens. 2023. “MRI Texture Analysis of T2-Weighted Images Is Preferred over Magnetization Transfer Imaging for Readily Longitudinal Quantification of Gut Fibrosis.” EUROPEAN RADIOLOGY 33 (9): 5943–52. https://doi.org/10.1007/s00330-023-09624-x.
Chicago author-date (all authors)
De Kock, Isabelle, Simon Bos, Louke Delrue, Sophie Van Welden, Peter Bunyard, Pieter Hindryckx, Martine De Vos, Geert Villeirs, and Debby Laukens. 2023. “MRI Texture Analysis of T2-Weighted Images Is Preferred over Magnetization Transfer Imaging for Readily Longitudinal Quantification of Gut Fibrosis.” EUROPEAN RADIOLOGY 33 (9): 5943–5952. doi:10.1007/s00330-023-09624-x.
Vancouver
1.
De Kock I, Bos S, Delrue L, Van Welden S, Bunyard P, Hindryckx P, et al. MRI texture analysis of T2-weighted images is preferred over magnetization transfer imaging for readily longitudinal quantification of gut fibrosis. EUROPEAN RADIOLOGY. 2023;33(9):5943–52.
IEEE
[1]
I. De Kock et al., “MRI texture analysis of T2-weighted images is preferred over magnetization transfer imaging for readily longitudinal quantification of gut fibrosis,” EUROPEAN RADIOLOGY, vol. 33, no. 9, pp. 5943–5952, 2023.
@article{01GS546BDBZ939SQCSJ64JPQ5A,
  abstract     = {{ObjectivesTo investigate the value of magnetization transfer (MT) MRI and texture analysis (TA) of T2-weighted MR images (T2WI) in the assessment of intestinal fibrosis in a mouse model.MethodsChronic colitis was induced in mice by cyclic administration of dextran sodium sulphate (DSS) resulting in chronic inflammation and progressive bowel fibrosis. Mice underwent 7-T MR imaging at various time points. Bowel wall MT ratio (MTR) and textural features (skewness, kurtosis, entropy), extracted by a filtration histogram technique, were correlated with histopathology. Performance of both techniques were validated using antifibrotic therapy. Finally, a retrospective study was conducted in five patients with Crohn's disease (CD) who underwent bowel surgery.ResultsMTR and texture entropy correlated with histopathological fibrosis (r = .85 and .81, respectively). Entropy was superior to MTR for monitoring bowel fibrosis in the presence of coexisting inflammation (linear regression R-2 = .93 versus R-2 = .01). Furthermore, texture entropy was able to assess antifibrotic therapy response (placebo mice versus treated mice at endpoint scan; Delta mean = 0.128, p < .0001). An increase in entropy was indicative of fibrosis accumulation in human CD strictures (inflammation: 1.29; mixed strictures: 1.4 and 1.48; fibrosis: 1.73 and 1.9).ConclusionMT imaging and TA of T2WI can both noninvasively detect established intestinal fibrosis in a mouse model. However, TA is especially useful for the longitudinal quantification of fibrosis in mixed inflammatory-fibrotic tissue, as well as for antifibrotic treatment response evaluation. This accessible post-processing technique merits further validation as the benefits for clinical practice as well as antifibrotic trial design would be numerous.}},
  author       = {{De Kock, Isabelle and Bos, Simon and Delrue, Louke and Van Welden, Sophie and Bunyard, Peter and Hindryckx, Pieter and De Vos, Martine and Villeirs, Geert and Laukens, Debby}},
  issn         = {{0938-7994}},
  journal      = {{EUROPEAN RADIOLOGY}},
  keywords     = {{Entropy,Fibrosis,Inflammation,Colitis,Magnetic resonance imaging}},
  language     = {{eng}},
  number       = {{9}},
  pages        = {{5943--5952}},
  title        = {{MRI texture analysis of T2-weighted images is preferred over magnetization transfer imaging for readily longitudinal quantification of gut fibrosis}},
  url          = {{http://doi.org/10.1007/s00330-023-09624-x}},
  volume       = {{33}},
  year         = {{2023}},
}
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