
MRI texture analysis of T2-weighted images is preferred over magnetization transfer imaging for readily longitudinal quantification of gut fibrosis
- Author
- Isabelle De Kock (UGent) , Simon Bos (UGent) , Louke Delrue (UGent) , Sophie Van Welden (UGent) , Peter Bunyard, Pieter Hindryckx (UGent) , Martine De Vos (UGent) , Geert Villeirs (UGent) and Debby Laukens (UGent)
- Organization
- Abstract
- ObjectivesTo investigate the value of magnetization transfer (MT) MRI and texture analysis (TA) of T2-weighted MR images (T2WI) in the assessment of intestinal fibrosis in a mouse model.MethodsChronic colitis was induced in mice by cyclic administration of dextran sodium sulphate (DSS) resulting in chronic inflammation and progressive bowel fibrosis. Mice underwent 7-T MR imaging at various time points. Bowel wall MT ratio (MTR) and textural features (skewness, kurtosis, entropy), extracted by a filtration histogram technique, were correlated with histopathology. Performance of both techniques were validated using antifibrotic therapy. Finally, a retrospective study was conducted in five patients with Crohn's disease (CD) who underwent bowel surgery.ResultsMTR and texture entropy correlated with histopathological fibrosis (r = .85 and .81, respectively). Entropy was superior to MTR for monitoring bowel fibrosis in the presence of coexisting inflammation (linear regression R-2 = .93 versus R-2 = .01). Furthermore, texture entropy was able to assess antifibrotic therapy response (placebo mice versus treated mice at endpoint scan; Delta mean = 0.128, p < .0001). An increase in entropy was indicative of fibrosis accumulation in human CD strictures (inflammation: 1.29; mixed strictures: 1.4 and 1.48; fibrosis: 1.73 and 1.9).ConclusionMT imaging and TA of T2WI can both noninvasively detect established intestinal fibrosis in a mouse model. However, TA is especially useful for the longitudinal quantification of fibrosis in mixed inflammatory-fibrotic tissue, as well as for antifibrotic treatment response evaluation. This accessible post-processing technique merits further validation as the benefits for clinical practice as well as antifibrotic trial design would be numerous.
- Keywords
- Entropy, Fibrosis, Inflammation, Colitis, Magnetic resonance imaging
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Citation
Please use this url to cite or link to this publication: http://hdl.handle.net/1854/LU-01GS546BDBZ939SQCSJ64JPQ5A
- MLA
- De Kock, Isabelle, et al. “MRI Texture Analysis of T2-Weighted Images Is Preferred over Magnetization Transfer Imaging for Readily Longitudinal Quantification of Gut Fibrosis.” EUROPEAN RADIOLOGY, vol. 33, no. 9, 2023, pp. 5943–52, doi:10.1007/s00330-023-09624-x.
- APA
- De Kock, I., Bos, S., Delrue, L., Van Welden, S., Bunyard, P., Hindryckx, P., … Laukens, D. (2023). MRI texture analysis of T2-weighted images is preferred over magnetization transfer imaging for readily longitudinal quantification of gut fibrosis. EUROPEAN RADIOLOGY, 33(9), 5943–5952. https://doi.org/10.1007/s00330-023-09624-x
- Chicago author-date
- De Kock, Isabelle, Simon Bos, Louke Delrue, Sophie Van Welden, Peter Bunyard, Pieter Hindryckx, Martine De Vos, Geert Villeirs, and Debby Laukens. 2023. “MRI Texture Analysis of T2-Weighted Images Is Preferred over Magnetization Transfer Imaging for Readily Longitudinal Quantification of Gut Fibrosis.” EUROPEAN RADIOLOGY 33 (9): 5943–52. https://doi.org/10.1007/s00330-023-09624-x.
- Chicago author-date (all authors)
- De Kock, Isabelle, Simon Bos, Louke Delrue, Sophie Van Welden, Peter Bunyard, Pieter Hindryckx, Martine De Vos, Geert Villeirs, and Debby Laukens. 2023. “MRI Texture Analysis of T2-Weighted Images Is Preferred over Magnetization Transfer Imaging for Readily Longitudinal Quantification of Gut Fibrosis.” EUROPEAN RADIOLOGY 33 (9): 5943–5952. doi:10.1007/s00330-023-09624-x.
- Vancouver
- 1.De Kock I, Bos S, Delrue L, Van Welden S, Bunyard P, Hindryckx P, et al. MRI texture analysis of T2-weighted images is preferred over magnetization transfer imaging for readily longitudinal quantification of gut fibrosis. EUROPEAN RADIOLOGY. 2023;33(9):5943–52.
- IEEE
- [1]I. De Kock et al., “MRI texture analysis of T2-weighted images is preferred over magnetization transfer imaging for readily longitudinal quantification of gut fibrosis,” EUROPEAN RADIOLOGY, vol. 33, no. 9, pp. 5943–5952, 2023.
@article{01GS546BDBZ939SQCSJ64JPQ5A, abstract = {{ObjectivesTo investigate the value of magnetization transfer (MT) MRI and texture analysis (TA) of T2-weighted MR images (T2WI) in the assessment of intestinal fibrosis in a mouse model.MethodsChronic colitis was induced in mice by cyclic administration of dextran sodium sulphate (DSS) resulting in chronic inflammation and progressive bowel fibrosis. Mice underwent 7-T MR imaging at various time points. Bowel wall MT ratio (MTR) and textural features (skewness, kurtosis, entropy), extracted by a filtration histogram technique, were correlated with histopathology. Performance of both techniques were validated using antifibrotic therapy. Finally, a retrospective study was conducted in five patients with Crohn's disease (CD) who underwent bowel surgery.ResultsMTR and texture entropy correlated with histopathological fibrosis (r = .85 and .81, respectively). Entropy was superior to MTR for monitoring bowel fibrosis in the presence of coexisting inflammation (linear regression R-2 = .93 versus R-2 = .01). Furthermore, texture entropy was able to assess antifibrotic therapy response (placebo mice versus treated mice at endpoint scan; Delta mean = 0.128, p < .0001). An increase in entropy was indicative of fibrosis accumulation in human CD strictures (inflammation: 1.29; mixed strictures: 1.4 and 1.48; fibrosis: 1.73 and 1.9).ConclusionMT imaging and TA of T2WI can both noninvasively detect established intestinal fibrosis in a mouse model. However, TA is especially useful for the longitudinal quantification of fibrosis in mixed inflammatory-fibrotic tissue, as well as for antifibrotic treatment response evaluation. This accessible post-processing technique merits further validation as the benefits for clinical practice as well as antifibrotic trial design would be numerous.}}, author = {{De Kock, Isabelle and Bos, Simon and Delrue, Louke and Van Welden, Sophie and Bunyard, Peter and Hindryckx, Pieter and De Vos, Martine and Villeirs, Geert and Laukens, Debby}}, issn = {{0938-7994}}, journal = {{EUROPEAN RADIOLOGY}}, keywords = {{Entropy,Fibrosis,Inflammation,Colitis,Magnetic resonance imaging}}, language = {{eng}}, number = {{9}}, pages = {{5943--5952}}, title = {{MRI texture analysis of T2-weighted images is preferred over magnetization transfer imaging for readily longitudinal quantification of gut fibrosis}}, url = {{http://doi.org/10.1007/s00330-023-09624-x}}, volume = {{33}}, year = {{2023}}, }
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