@article{01GRR66RDV1GDA0CVV1FH4TA2H,
  abstract     = {{Background: Urinary liver-type fatty acid-binding protein (uL-FABP) is a promising biomarker to detect early chronic kidney disease (CKD) in cats. Few healthy cats show increased uL-FABP for unknown reasons. Objectives: The objective of this study was to evaluate uL-FABP in a large healthy elderly cat population comparing cats with and without International Renal Interest Society (IRIS) stage 1 CKD and with and without borderline proteinuria. Methods: This was a cross-sectional study. One hundred ninety-six clinically healthy client-owned cats of >= 7 years old were subdivided based on two criteria: (1) having either IRIS stage 1 CKD or no evidence of CKD and (2) having borderline proteinuria or no proteinuria. Urinary L-FABP was measured using a validated commercially available feline L-FABP ELISA. Results: Overall, uL-FABP was detectable in 6/196 (3%) healthy elderly cats. For the first subdivision, nine (5%) cats had IRIS stage 1 CKD, 184 cats had no evidence CKD and three cats were excluded. All cats with IRIS stage 1 CKD had uL-FABP concentrations below the detection limit, whereas 6/184 (3%) cats without IRIS stage 1 CKD had detectable uL-FABP concentrations (median 1.79 ng/ml, range 0.79-3.66 ng/ml). For the second subdivision, 47 (24%) cats had borderline proteinuria, 147 cats had no proteinuria and two cats were excluded. One of the borderline proteinuric cats had a detectable uL-FABP concentration, whereas the other five cats with detectable uL-FABP concentrations were non-proteinuric. Conclusion: With the current assay, the screening potential of uL-FABP as an early biomarker for feline CKD is limited as uL-FABP was rarely detected in clinically healthy elderly cats independently of the presence of either IRIS stage 1 CKD or borderline proteinuria.}},
  author       = {{Kongtasai, Thirawut and Paepe, Dominique and Mortier, Femke and Marynissen, Sofie and Meyer, Evelyne and Duchateau, Luc and Daminet, Sylvie}},
  issn         = {{2053-1095}},
  journal      = {{VETERINARY MEDICINE AND SCIENCE}},
  keywords     = {{GLOMERULAR-FILTRATION-RATE,L-FABP,BIOMARKERS,MARKERS,CREATININE,EXCRETION,DIAGNOSIS,INJURY,ESRD,renal biomarker,aged cats,screening,feline CKD}},
  language     = {{eng}},
  number       = {{1}},
  pages        = {{3--12}},
  publisher    = {{Wiley}},
  title        = {{Urinary liver-type fatty acid-binding protein in clinically healthy elderly cats : evaluation of its potential to detect IRIS stage 1 chronic kidney disease and borderline proteinuria}},
  url          = {{http://doi.org/10.1002/vms3.1003}},
  volume       = {{9}},
  year         = {{2023}},
}

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