A self-sustaining layer of early-life-origin B cells drives steady-state IgA responses in the adult gut
- Author
- Stefano Vergani, Konjit Getachew Muleta, Clément Da Silva, Alexander Doyle, Trine Ahn Kristiansen, Selene Sodini, Niklas Krausse, Giorgia Montano, Knut Kotarsky, Joy Nakawesi, Hugo Åkerstrand, Stijn Vanhee (UGent) , Sneh Lata Gupta, David Bryder, William Winston Agace, Katharina Lahl and Joan Yuan
- Organization
- Abstract
- The adult immune system consists of cells that emerged at various times during ontogeny. We aimed to define the relationship between developmental origin and composition of the adult B cell pool during unper-turbed hematopoiesis. Lineage tracing stratified murine adult B cells based on the timing of output, revealing that a substantial portion originated within a restricted neonatal window. In addition to B-1a cells, early-life time-stamped B cells included clonally interrelated IgA plasma cells in the gut and bone marrow. These were actively maintained by B cell memory within gut chronic germinal centers and contained commensal micro -biota reactivity. Neonatal rotavirus infection recruited recurrent IgA clones that were distinct from those arising by infection with the same antigen in adults. Finally, gut IgA plasma cells arose from the same hemato-poietic progenitors as B-1a cells during ontogeny. Thus, a complex layer of neonatally imprinted B cells confer unique antibody responses later in life.
- Keywords
- Infectious Diseases, Immunology, Immunology and Allergy, PLASMA-CELLS, BONE-MARROW, ROTAVIRUS INFECTION, POSITIVE SELECTION, COMMENSAL-BACTERIA, MARGINAL ZONE, IN-VIVO, EXPRESSION, IMMUNITY, INNATE
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Citation
Please use this url to cite or link to this publication: http://hdl.handle.net/1854/LU-01GRDG98EHMC6RBS2AYMKDSKGF
- MLA
- Vergani, Stefano, et al. “A Self-Sustaining Layer of Early-Life-Origin B Cells Drives Steady-State IgA Responses in the Adult Gut.” IMMUNITY, vol. 55, no. 10, 2022, pp. 1829-1842.e6, doi:10.1016/j.immuni.2022.08.018.
- APA
- Vergani, S., Muleta, K. G., Da Silva, C., Doyle, A., Kristiansen, T. A., Sodini, S., … Yuan, J. (2022). A self-sustaining layer of early-life-origin B cells drives steady-state IgA responses in the adult gut. IMMUNITY, 55(10), 1829-1842.e6. https://doi.org/10.1016/j.immuni.2022.08.018
- Chicago author-date
- Vergani, Stefano, Konjit Getachew Muleta, Clément Da Silva, Alexander Doyle, Trine Ahn Kristiansen, Selene Sodini, Niklas Krausse, et al. 2022. “A Self-Sustaining Layer of Early-Life-Origin B Cells Drives Steady-State IgA Responses in the Adult Gut.” IMMUNITY 55 (10): 1829-1842.e6. https://doi.org/10.1016/j.immuni.2022.08.018.
- Chicago author-date (all authors)
- Vergani, Stefano, Konjit Getachew Muleta, Clément Da Silva, Alexander Doyle, Trine Ahn Kristiansen, Selene Sodini, Niklas Krausse, Giorgia Montano, Knut Kotarsky, Joy Nakawesi, Hugo Åkerstrand, Stijn Vanhee, Sneh Lata Gupta, David Bryder, William Winston Agace, Katharina Lahl, and Joan Yuan. 2022. “A Self-Sustaining Layer of Early-Life-Origin B Cells Drives Steady-State IgA Responses in the Adult Gut.” IMMUNITY 55 (10): 1829-1842.e6. doi:10.1016/j.immuni.2022.08.018.
- Vancouver
- 1.Vergani S, Muleta KG, Da Silva C, Doyle A, Kristiansen TA, Sodini S, et al. A self-sustaining layer of early-life-origin B cells drives steady-state IgA responses in the adult gut. IMMUNITY. 2022;55(10):1829-1842.e6.
- IEEE
- [1]S. Vergani et al., “A self-sustaining layer of early-life-origin B cells drives steady-state IgA responses in the adult gut,” IMMUNITY, vol. 55, no. 10, pp. 1829-1842.e6, 2022.
@article{01GRDG98EHMC6RBS2AYMKDSKGF,
abstract = {{The adult immune system consists of cells that emerged at various times during ontogeny. We aimed to define the relationship between developmental origin and composition of the adult B cell pool during unper-turbed hematopoiesis. Lineage tracing stratified murine adult B cells based on the timing of output, revealing that a substantial portion originated within a restricted neonatal window. In addition to B-1a cells, early-life time-stamped B cells included clonally interrelated IgA plasma cells in the gut and bone marrow. These were actively maintained by B cell memory within gut chronic germinal centers and contained commensal micro -biota reactivity. Neonatal rotavirus infection recruited recurrent IgA clones that were distinct from those arising by infection with the same antigen in adults. Finally, gut IgA plasma cells arose from the same hemato-poietic progenitors as B-1a cells during ontogeny. Thus, a complex layer of neonatally imprinted B cells confer unique antibody responses later in life.}},
author = {{Vergani, Stefano and Muleta, Konjit Getachew and Da Silva, Clément and Doyle, Alexander and Kristiansen, Trine Ahn and Sodini, Selene and Krausse, Niklas and Montano, Giorgia and Kotarsky, Knut and Nakawesi, Joy and Åkerstrand, Hugo and Vanhee, Stijn and Gupta, Sneh Lata and Bryder, David and Agace, William Winston and Lahl, Katharina and Yuan, Joan}},
issn = {{1074-7613}},
journal = {{IMMUNITY}},
keywords = {{Infectious Diseases,Immunology,Immunology and Allergy,PLASMA-CELLS,BONE-MARROW,ROTAVIRUS INFECTION,POSITIVE SELECTION,COMMENSAL-BACTERIA,MARGINAL ZONE,IN-VIVO,EXPRESSION,IMMUNITY,INNATE}},
language = {{eng}},
number = {{10}},
pages = {{1829--1842.e6}},
title = {{A self-sustaining layer of early-life-origin B cells drives steady-state IgA responses in the adult gut}},
url = {{http://doi.org/10.1016/j.immuni.2022.08.018}},
volume = {{55}},
year = {{2022}},
}
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