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Associations of pulmonary function with MRI brain volumes : a coordinated multi-study analysis

Stefan Frenzel, Joshua C. Bis, Elias F. Gudmundsson, Adrienne O'Donnell, Jeannette Simino, Amber Yaqub, Traci M. Bartz, Guy Brusselle (UGent) , Robin Buelow, Charles S. DeCarlil, et al.
(2022) JOURNAL OF ALZHEIMERS DISEASE. 90(3). p.1073-1083
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Abstract
Background: Previous studies suggest poor pulmonary function is associated with increased burden of cerebral white matter hyperintensities and brain atrophy among elderly individuals, but the results are inconsistent. Objective: To study the cross-sectional associations of pulmonary function with structural brain variables. Methods: Data from six large community-based samples (N = 11,091) were analyzed. Spirometric measurements were standardized with respect to age, sex, height, and ethnicity using reference equations of the Global Lung Function Initiative. Associations of forced expiratory volume in 1 second (FEV1), forced vital capacity (FVC), and their ratio FEV1/FVC with brain volume, gray matter volume, hippocampal volume, and volume of white matter hyperintensities were investigated using multivariable linear regressions for each study separately and then combined using random-effect meta-analyses. Results: FEV1 and FVC were positively associated with brain volume, gray matter volume, and hippocampal volume, and negatively associated with white matter hyperintensities volume after multiple testing correction, with little heterogeneity present between the studies. For instance, an increase of FVC by one unit was associated with 3.5 ml higher brain volume (95% CI: [2.2, 4.9]). In contrast, results for FEV1/FVC were more heterogeneous across studies, with significant positive associations with brain volume, gray matter volume, and hippocampal volume, but not white matter hyperintensities volume. Associations of brain variables with both FEV1 and FVC were consistently stronger than with FEV1/FVC, specifically with brain volume and white matter hyperintensities volume. Conclusion: In cross-sectional analyses, worse pulmonary function is associated with smaller brain volumes and higher white matter hyperintensities burden.
Keywords
respiratory function tests, magnetic resonance imaging, epidemiology, Dementia

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MLA
Frenzel, Stefan, et al. “Associations of Pulmonary Function with MRI Brain Volumes : A Coordinated Multi-Study Analysis.” JOURNAL OF ALZHEIMERS DISEASE, vol. 90, no. 3, IOS Press, 2022, pp. 1073–83, doi:10.3233/JAD-220667.
APA
Frenzel, S., Bis, J. C., Gudmundsson, E. F., O’Donnell, A., Simino, J., Yaqub, A., … Seshadri, S. (2022). Associations of pulmonary function with MRI brain volumes : a coordinated multi-study analysis. JOURNAL OF ALZHEIMERS DISEASE, 90(3), 1073–1083. https://doi.org/10.3233/JAD-220667
Chicago author-date
Frenzel, Stefan, Joshua C. Bis, Elias F. Gudmundsson, Adrienne O’Donnell, Jeannette Simino, Amber Yaqub, Traci M. Bartz, et al. 2022. “Associations of Pulmonary Function with MRI Brain Volumes : A Coordinated Multi-Study Analysis.” JOURNAL OF ALZHEIMERS DISEASE 90 (3): 1073–83. https://doi.org/10.3233/JAD-220667.
Chicago author-date (all authors)
Frenzel, Stefan, Joshua C. Bis, Elias F. Gudmundsson, Adrienne O’Donnell, Jeannette Simino, Amber Yaqub, Traci M. Bartz, Guy Brusselle, Robin Buelow, Charles S. DeCarlil, Ralf Ewert, Sina A. Gharib, Saptaparni Ghosh, Monica Gireud-Goss, Rebecca F. Gottesman, M. Arfan Ikram, David S. Knopmans, Lenore J. Launert, Stephanie J. London, W. T. Longstreth, Oscar L. Lopez, Debora Melo van Lent, George O’Connord, Claudia L. Satizabal, Srishti Shresthaf, Sigurdur Sigurdsson, Beate Stubbe, Rajesh Talluri, Ramachandran S. Vasan, Meike W. Vernooij, Henry Voelzke, Kerri L. Wiggins, Bing Yua, Alexa S. Beiser, Vilmundur Gudnason, Thomas Mosley, Bruce M. Psaty, Frank J. Wolters, Hans J. Grabe, and Sudha Seshadri. 2022. “Associations of Pulmonary Function with MRI Brain Volumes : A Coordinated Multi-Study Analysis.” JOURNAL OF ALZHEIMERS DISEASE 90 (3): 1073–1083. doi:10.3233/JAD-220667.
Vancouver
1.
Frenzel S, Bis JC, Gudmundsson EF, O’Donnell A, Simino J, Yaqub A, et al. Associations of pulmonary function with MRI brain volumes : a coordinated multi-study analysis. JOURNAL OF ALZHEIMERS DISEASE. 2022;90(3):1073–83.
IEEE
[1]
S. Frenzel et al., “Associations of pulmonary function with MRI brain volumes : a coordinated multi-study analysis,” JOURNAL OF ALZHEIMERS DISEASE, vol. 90, no. 3, pp. 1073–1083, 2022.
@article{01GR8R33JBSWYJT6AN8TCKA7QN,
  abstract     = {{Background: Previous studies suggest poor pulmonary function is associated with increased burden of cerebral white matter hyperintensities and brain atrophy among elderly individuals, but the results are inconsistent.

Objective: To study the cross-sectional associations of pulmonary function with structural brain variables.

Methods: Data from six large community-based samples (N = 11,091) were analyzed. Spirometric measurements were standardized with respect to age, sex, height, and ethnicity using reference equations of the Global Lung Function Initiative. Associations of forced expiratory volume in 1 second (FEV1), forced vital capacity (FVC), and their ratio FEV1/FVC with brain volume, gray matter volume, hippocampal volume, and volume of white matter hyperintensities were investigated using multivariable linear regressions for each study separately and then combined using random-effect meta-analyses.

Results: FEV1 and FVC were positively associated with brain volume, gray matter volume, and hippocampal volume, and negatively associated with white matter hyperintensities volume after multiple testing correction, with little heterogeneity present between the studies. For instance, an increase of FVC by one unit was associated with 3.5 ml higher brain volume (95% CI: [2.2, 4.9]). In contrast, results for FEV1/FVC were more heterogeneous across studies, with significant positive associations with brain volume, gray matter volume, and hippocampal volume, but not white matter hyperintensities volume. Associations of brain variables with both FEV1 and FVC were consistently stronger than with FEV1/FVC, specifically with brain volume and white matter hyperintensities volume.

Conclusion: In cross-sectional analyses, worse pulmonary function is associated with smaller brain volumes and higher white matter hyperintensities burden.}},
  author       = {{Frenzel, Stefan and  Bis, Joshua C. and  Gudmundsson, Elias F. and  O'Donnell, Adrienne and  Simino, Jeannette and  Yaqub, Amber and  Bartz, Traci M. and Brusselle, Guy and  Buelow, Robin and  DeCarlil, Charles S. and  Ewert, Ralf and  Gharib, Sina A. and  Ghosh, Saptaparni and  Gireud-Goss, Monica and  Gottesman, Rebecca F. and  Ikram, M. Arfan and  Knopmans, David S. and  Launert, Lenore J. and  London, Stephanie J. and  Longstreth, W. T. and  Lopez, Oscar L. and  van Lent, Debora Melo and  O'Connord, George and  Satizabal, Claudia L. and  Shresthaf, Srishti and  Sigurdsson, Sigurdur and  Stubbe, Beate and  Talluri, Rajesh and  Vasan, Ramachandran S. and  Vernooij, Meike W. and  Voelzke, Henry and  Wiggins, Kerri L. and  Yua, Bing and  Beiser, Alexa S. and  Gudnason, Vilmundur and  Mosley, Thomas and  Psaty, Bruce M. and  Wolters, Frank J. and Grabe, Hans J. and Seshadri, Sudha}},
  issn         = {{1387-2877}},
  journal      = {{JOURNAL OF ALZHEIMERS DISEASE}},
  keywords     = {{respiratory function tests,magnetic resonance imaging,epidemiology,Dementia}},
  language     = {{eng}},
  number       = {{3}},
  pages        = {{1073--1083}},
  publisher    = {{IOS Press}},
  title        = {{Associations of pulmonary function with MRI brain volumes : a coordinated multi-study analysis}},
  url          = {{http://doi.org/10.3233/JAD-220667}},
  volume       = {{90}},
  year         = {{2022}},
}
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