Academic Bibliography

 Search 200 years of publications by Ghent University researchers.
Advanced search
1 file | 2.39 MB
Add to list
  1. Search results
  2. Oncogenic deubiquitination controls t...

Oncogenic deubiquitination controls tyrosine kinase signaling and therapy response in acute lymphoblastic leukemia

Qi Jin, Blanca Gutierrez Diaz, Tim Pieters (UGent) , Yalu Zhou, Sonali Narang, Igor Fijalkowski (UGent) , Cristina Borin (UGent) , Jolien Van Laere (UGent) , Monique Payton, Byoung-Kyu Cho, et al.
(2022) SCIENCE ADVANCES. 8(49).
Author
Organization
Project
Abstract
Dysregulation of kinase signaling pathways favors tumor cell survival and therapy resistance in cancer. Here, we reveal a posttranslational regulation of kinase signaling and nuclear receptor activity via deubiquitination in T cell acute lymphoblastic leukemia (T-ALL). We observed that the ubiquitin-specific protease 11 (USP11) is highly expressed and associates with poor prognosis in T-ALL. USP11 ablation inhibits leukemia progression in vivo, sparing normal hematopoiesis. USP11 forms a complex with USP7 to deubiquitinate the oncogenic lymphocyte cell-specific protein-tyrosine kinase (LCK) and enhance its activity. Impairment of LCK activity leads to increased glucocorticoid receptor (GR) expression and glucocorticoids sensitivity. Genetic knockout of USP7 improved the antileukemic efficacy of glucocorticoids in vivo. The transcriptional activation of GR target genes is orchestrated by the deubiquitinase activity and mediated via an increase in enhancer-promoter interaction intensity. Our data unveil how dysregulated deubiquitination controls leukemia survival and drug resistance, suggesting previously unidentified therapeutic combinations toward targeting leukemia.
Keywords
Multidisciplinary

Downloads

  • Download
    sciadv.abq8437.pdf
    • full text (Published version)
    • |
    • open access
    • |
    • PDF
    • |
    • 2.39 MB

Citation

Please use this url to cite or link to this publication:

MLA
Jin, Qi, et al. “Oncogenic Deubiquitination Controls Tyrosine Kinase Signaling and Therapy Response in Acute Lymphoblastic Leukemia.” SCIENCE ADVANCES, vol. 8, no. 49, American Association for the Advancement of Science (AAAS), 2022, doi:10.1126/sciadv.abq8437.
APA
Jin, Q., Gutierrez Diaz, B., Pieters, T., Zhou, Y., Narang, S., Fijalkowski, I., … Ntziachristos, P. (2022). Oncogenic deubiquitination controls tyrosine kinase signaling and therapy response in acute lymphoblastic leukemia. SCIENCE ADVANCES, 8(49). https://doi.org/10.1126/sciadv.abq8437
Chicago author-date
Jin, Qi, Blanca Gutierrez Diaz, Tim Pieters, Yalu Zhou, Sonali Narang, Igor Fijalkowski, Cristina Borin, et al. 2022. “Oncogenic Deubiquitination Controls Tyrosine Kinase Signaling and Therapy Response in Acute Lymphoblastic Leukemia.” SCIENCE ADVANCES 8 (49). https://doi.org/10.1126/sciadv.abq8437.
Chicago author-date (all authors)
Jin, Qi, Blanca Gutierrez Diaz, Tim Pieters, Yalu Zhou, Sonali Narang, Igor Fijalkowski, Cristina Borin, Jolien Van Laere, Monique Payton, Byoung-Kyu Cho, Cuijuan Han, Limin Sun, Valentina Serafin, George Yacu, Wouter Von Loocke, Giuseppe Basso, Giulia Veltri, Ingrid Dreveny, Issam Ben-Sahra, Young Ah Goo, Stephanie L. Safgren, Yi-Chien Tsai, Beat Bornhauser, Praveen Kumar Suraneni, Alexandre Gaspar-Maia, Irawati Kandela, Pieter Van Vlierberghe, John D. Crispino, Aristotelis Tsirigos, and Panagiotis Ntziachristos. 2022. “Oncogenic Deubiquitination Controls Tyrosine Kinase Signaling and Therapy Response in Acute Lymphoblastic Leukemia.” SCIENCE ADVANCES 8 (49). doi:10.1126/sciadv.abq8437.
Vancouver
1.
Jin Q, Gutierrez Diaz B, Pieters T, Zhou Y, Narang S, Fijalkowski I, et al. Oncogenic deubiquitination controls tyrosine kinase signaling and therapy response in acute lymphoblastic leukemia. SCIENCE ADVANCES. 2022;8(49).
IEEE
[1]
Q. Jin et al., “Oncogenic deubiquitination controls tyrosine kinase signaling and therapy response in acute lymphoblastic leukemia,” SCIENCE ADVANCES, vol. 8, no. 49, 2022.
@article{01GR1EHW48W52T9HMXBYQYAAW6,
  abstract     = {{Dysregulation of kinase signaling pathways favors tumor cell survival and therapy resistance in cancer. Here, we reveal a posttranslational regulation of kinase signaling and nuclear receptor activity via deubiquitination in T cell acute lymphoblastic leukemia (T-ALL). We observed that the ubiquitin-specific protease 11 (USP11) is highly expressed and associates with poor prognosis in T-ALL. USP11 ablation inhibits leukemia progression in vivo, sparing normal hematopoiesis. USP11 forms a complex with USP7 to deubiquitinate the oncogenic lymphocyte cell-specific protein-tyrosine kinase (LCK) and enhance its activity. Impairment of LCK activity leads to increased glucocorticoid receptor (GR) expression and glucocorticoids sensitivity. Genetic knockout of USP7 improved the antileukemic efficacy of glucocorticoids in vivo. The transcriptional activation of GR target genes is orchestrated by the deubiquitinase activity and mediated via an increase in enhancer-promoter interaction intensity. Our data unveil how dysregulated deubiquitination controls leukemia survival and drug resistance, suggesting previously unidentified therapeutic combinations toward targeting leukemia.}},
  articleno    = {{eabq8437}},
  author       = {{Jin, Qi and Gutierrez Diaz, Blanca and Pieters, Tim and Zhou, Yalu and Narang, Sonali and Fijalkowski, Igor and Borin, Cristina and Van Laere, Jolien and Payton, Monique and Cho, Byoung-Kyu and Han, Cuijuan and Sun, Limin and Serafin, Valentina and Yacu, George and Von Loocke, Wouter and Basso, Giuseppe and Veltri, Giulia and Dreveny, Ingrid and Ben-Sahra, Issam and Goo, Young Ah and Safgren, Stephanie L. and Tsai, Yi-Chien and Bornhauser, Beat and Suraneni, Praveen Kumar and Gaspar-Maia, Alexandre and Kandela, Irawati and Van Vlierberghe, Pieter and Crispino, John D. and Tsirigos, Aristotelis and Ntziachristos, Panagiotis}},
  issn         = {{2375-2548}},
  journal      = {{SCIENCE ADVANCES}},
  keywords     = {{Multidisciplinary}},
  language     = {{eng}},
  number       = {{49}},
  pages        = {{17}},
  publisher    = {{American Association for the Advancement of Science (AAAS)}},
  title        = {{Oncogenic deubiquitination controls tyrosine kinase signaling and therapy response in acute lymphoblastic leukemia}},
  url          = {{http://doi.org/10.1126/sciadv.abq8437}},
  volume       = {{8}},
  year         = {{2022}},
}
Altmetric
View in Altmetric
Web of Science
Times cited: