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The GpIA7 effector from the potato cyst nematode Globodera pallida targets potato EBP1 and interferes with the plant cell cycle

Mirela C Coke, Sophie Mantelin, Peter Thorpe, Catherine J Lilley, Kathryn M Wright, Daniel S Shaw, Adams Chande, John Jones (UGent) and Peter E Urwin
(2021) JOURNAL OF EXPERIMENTAL BOTANY. 72(20). p.7301-7315
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Abstract
The potato cyst nematode Globodera pallida acquires all of its nutrients from an elaborate feeding site that it establishes in a host plant root. Normal development of the root cells is re-programmed in a process coordinated by secreted nematode effector proteins. The biological function of the G. pallida GpIA7 effector was investigated in this study. GpIA7 is specifically expressed in the subventral pharyngeal glands of pre-parasitic stage nematodes. Ectopic expression of GpIA7 in potato plants affected plant growth and development, suggesting a potential role for this effector in feeding site establishment. Potato plants overexpressing GpIA7 were shorter, with reduced tuber weight and delayed flowering. We provide evidence that GpIA7 associates with the plant growth regulator StEBP1 (ErbB-3 epidermal growth factor receptor-binding protein 1). GpIA7 modulates the regulatory function of StEBP1, altering the expression level of downstream target genes, including ribonucleotide reductase 2, cyclin D3;1, and retinoblastoma related 1, which are down-regulated in plants overexpressing GpIA7. We provide an insight into the molecular mechanism used by the nematode to manipulate the host cell cycle and demonstrate that this may rely, at least in part, on hindering the function of host EBP1.
Keywords
Plant Science, Physiology, Cell cycle, cyclin D3;1, EBP1, endoreduplication, potato, RBR1, nematode, ERBB-3 BINDING-PROTEIN, GLOBAL ANALYSIS, PROLIFERATION, DIFFERENTIATION, ENDOREDUPLICATION, EXPRESSION, ENDOREPLICATION, TRANSFORMATION, TRANSCRIPTOME, REPLICATION

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MLA
Coke, Mirela C., et al. “The GpIA7 Effector from the Potato Cyst Nematode Globodera Pallida Targets Potato EBP1 and Interferes with the Plant Cell Cycle.” JOURNAL OF EXPERIMENTAL BOTANY, edited by James Murray, vol. 72, no. 20, 2021, pp. 7301–15, doi:10.1093/jxb/erab353.
APA
Coke, M. C., Mantelin, S., Thorpe, P., Lilley, C. J., Wright, K. M., Shaw, D. S., … Urwin, P. E. (2021). The GpIA7 effector from the potato cyst nematode Globodera pallida targets potato EBP1 and interferes with the plant cell cycle. JOURNAL OF EXPERIMENTAL BOTANY, 72(20), 7301–7315. https://doi.org/10.1093/jxb/erab353
Chicago author-date
Coke, Mirela C, Sophie Mantelin, Peter Thorpe, Catherine J Lilley, Kathryn M Wright, Daniel S Shaw, Adams Chande, John Jones, and Peter E Urwin. 2021. “The GpIA7 Effector from the Potato Cyst Nematode Globodera Pallida Targets Potato EBP1 and Interferes with the Plant Cell Cycle.” Edited by James Murray. JOURNAL OF EXPERIMENTAL BOTANY 72 (20): 7301–15. https://doi.org/10.1093/jxb/erab353.
Chicago author-date (all authors)
Coke, Mirela C, Sophie Mantelin, Peter Thorpe, Catherine J Lilley, Kathryn M Wright, Daniel S Shaw, Adams Chande, John Jones, and Peter E Urwin. 2021. “The GpIA7 Effector from the Potato Cyst Nematode Globodera Pallida Targets Potato EBP1 and Interferes with the Plant Cell Cycle.” Ed by. James Murray. JOURNAL OF EXPERIMENTAL BOTANY 72 (20): 7301–7315. doi:10.1093/jxb/erab353.
Vancouver
1.
Coke MC, Mantelin S, Thorpe P, Lilley CJ, Wright KM, Shaw DS, et al. The GpIA7 effector from the potato cyst nematode Globodera pallida targets potato EBP1 and interferes with the plant cell cycle. Murray J, editor. JOURNAL OF EXPERIMENTAL BOTANY. 2021;72(20):7301–15.
IEEE
[1]
M. C. Coke et al., “The GpIA7 effector from the potato cyst nematode Globodera pallida targets potato EBP1 and interferes with the plant cell cycle,” JOURNAL OF EXPERIMENTAL BOTANY, vol. 72, no. 20, pp. 7301–7315, 2021.
@article{01GQM75SP3CJW10S0QBKVGTP4B,
  abstract     = {{The potato cyst nematode Globodera pallida acquires all of its nutrients from an elaborate feeding site that it establishes in a host plant root. Normal development of the root cells is re-programmed in a process coordinated by secreted nematode effector proteins. The biological function of the G. pallida GpIA7 effector was investigated in this study. GpIA7 is specifically expressed in the subventral pharyngeal glands of pre-parasitic stage nematodes. Ectopic expression of GpIA7 in potato plants affected plant growth and development, suggesting a potential role for this effector in feeding site establishment. Potato plants overexpressing GpIA7 were shorter, with reduced tuber weight and delayed flowering. We provide evidence that GpIA7 associates with the plant growth regulator StEBP1 (ErbB-3 epidermal growth factor receptor-binding protein 1). GpIA7 modulates the regulatory function of StEBP1, altering the expression level of downstream target genes, including ribonucleotide reductase 2, cyclin D3;1, and retinoblastoma related 1, which are down-regulated in plants overexpressing GpIA7. We provide an insight into the molecular mechanism used by the nematode to manipulate the host cell cycle and demonstrate that this may rely, at least in part, on hindering the function of host EBP1.}},
  author       = {{Coke, Mirela C and Mantelin, Sophie and Thorpe, Peter and Lilley, Catherine J and Wright, Kathryn M and Shaw, Daniel S and Chande, Adams and Jones, John and Urwin, Peter E}},
  editor       = {{Murray, James}},
  issn         = {{0022-0957}},
  journal      = {{JOURNAL OF EXPERIMENTAL BOTANY}},
  keywords     = {{Plant Science,Physiology,Cell cycle,cyclin D3;1,EBP1,endoreduplication,potato,RBR1,nematode,ERBB-3 BINDING-PROTEIN,GLOBAL ANALYSIS,PROLIFERATION,DIFFERENTIATION,ENDOREDUPLICATION,EXPRESSION,ENDOREPLICATION,TRANSFORMATION,TRANSCRIPTOME,REPLICATION}},
  language     = {{eng}},
  number       = {{20}},
  pages        = {{7301--7315}},
  title        = {{The GpIA7 effector from the potato cyst nematode Globodera pallida targets potato EBP1 and interferes with the plant cell cycle}},
  url          = {{http://dx.doi.org/10.1093/jxb/erab353}},
  volume       = {{72}},
  year         = {{2021}},
}
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