@article{01GQJ7XNKYT3NSTX8JNF81TS28,
  abstract     = {{In a previous vaccination study in pigs, heterologous prime-boost vaccination with whole-inactivated H1N1 virus vaccines (WIV) induced superior antibody responses and protection compared to homologous prime-boost vaccination. However, no pan-H1 antibody response was induced. Therefore, to stimulate both local and systemic immune responses, we first vaccinated pigs intranasally with a pseudorabies vector vaccine expressing the pH1N1 hemagglutinin (prvCA09) followed by a homologous or heterologous WIV booster vaccine. Homologous and heterologous WIV-WIV vaccinated groups and mock-vaccinated or prvCA09 single-vaccinated pigs served as control groups. Five weeks after the second vaccination, pigs were challenged with a homologous pH1N1 or one of two heterologous H1N2 swine influenza A virus strains. A single prvCA09 vaccination resulted in complete protection against homologous challenge, and vector-WIV vaccinated groups were significantly better protected against heterologous challenge compared to the challenge control group or WIV-WIV vaccinated groups. Furthermore, vector-WIV vaccination resulted in broader hemagglutination inhibition antibody responses compared to WIV-WIV vaccination and higher numbers of antibody-secreting cells in peripheral blood, draining lymph nodes and nasal mucosa. However, even though vector-WIV vaccination induced stronger antibody responses and protection, we still failed to induce a pan-H1 antibody response.}},
  articleno    = {{1826}},
  author       = {{Parys, Anna and Vandoorn, Elien and Chiers, Koen and  Passvogel, Katharina and  Fuchs, Walter and  Mettenleiter, Thomas C. and Van Reeth, Kristien}},
  issn         = {{2076-393X}},
  journal      = {{VACCINES}},
  keywords     = {{swine influenza A virus,H1N1,vaccination,heterologous prime-boost,vectored vaccine,attenuated PrV strain Bartha,antibody,cross-reactivity,ELISPOT,cross-protection,PSEUDORABIES VIRUS,IMMUNE-RESPONSES,PIGS,HEMAGGLUTININ,EFFICACY,PROTECTION,INFECTION,OUTBREAK,VECTOR,FARM}},
  language     = {{eng}},
  number       = {{11}},
  pages        = {{16}},
  title        = {{Exploring prime-boost vaccination regimens with different H1N1 swine influenza a virus strains and vaccine platforms}},
  url          = {{http://doi.org/10.3390/vaccines10111826}},
  volume       = {{10}},
  year         = {{2022}},
}

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