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Hybrid biodegradable electrospun scaffolds based on poly(l-lactic acid) and reduced graphene oxide with improved piezoelectric response

(2022) POLYMER JOURNAL. 54(10). p.1237-1252
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Abstract
Piezoelectric poly-L-lactide (PLLA) is a biodegradable polymer used in various biomedical applications. However, tailoring and controlling the structure of PLLA to enhance its piezoelectric response remains a challenge. In this work, extensive characterization was performed to reveal the effect of the reduced graphene oxide (rGO) content (0.2, 0.7, and 1.0 wt%) on the morphology, structure, thermal and piezoelectric behavior of PLLA scaffolds. Randomly oriented homogeneous fibers and a quasi-amorphous structure for pure PLLA and hybrid PLLA-rGO scaffolds were revealed. The addition of rGO affected the molecular structure of the PLLA scaffolds: for example, the number of polar C=O functional groups was increased. Increasing the content of rGO to 1 wt% resulted in decreased glass transition and melting temperatures and increased the degree of crystallinity of the scaffolds. The addition of 0.2 wt% rGO enhanced the effective local vertical and lateral piezoresponses by 2.3 and 15.4 times, respectively, in comparison with pure PLLA fibers. The presence of the shear piezoelectric alpha-phase (P2(1)2(1)2(1)) in uniaxially oriented PLLA fibers and C=O bond rotation in the polymer chains explained the observed piezoresponse. Thus, this study revealed routes to prepare hybrid biodegradable scaffolds with enhanced piezoresponse for tissue engineering applications.
Keywords
RING-OPENING POLYMERIZATION, DOUBLE-MELTING BEHAVIOR, CRYSTAL-STRUCTURE, LACTIC-ACID, PHYSICAL-PROPERTIES, POLY(LACTIC ACID), X-RAY, CRYSTALLIZATION, KINETICS, BONE

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MLA
Pariy, Igor O., et al. “Hybrid Biodegradable Electrospun Scaffolds Based on Poly(l-Lactic Acid) and Reduced Graphene Oxide with Improved Piezoelectric Response.” POLYMER JOURNAL, vol. 54, no. 10, 2022, pp. 1237–52, doi:10.1038/s41428-022-00669-1.
APA
Pariy, I. O., Chernozem, R., Chernozem, P., Mukhortova, Y. R., Skirtach, A., Shvartsman, V. V., … Surmenev, R. A. (2022). Hybrid biodegradable electrospun scaffolds based on poly(l-lactic acid) and reduced graphene oxide with improved piezoelectric response. POLYMER JOURNAL, 54(10), 1237–1252. https://doi.org/10.1038/s41428-022-00669-1
Chicago author-date
Pariy, Igor O., Roman Chernozem, Polina Chernozem, Yulia R. Mukhortova, Andre Skirtach, Vladimir V. Shvartsman, Doru C. Lupascu, Maria A. Surmeneva, Sanjay Mathur, and Roman A. Surmenev. 2022. “Hybrid Biodegradable Electrospun Scaffolds Based on Poly(l-Lactic Acid) and Reduced Graphene Oxide with Improved Piezoelectric Response.” POLYMER JOURNAL 54 (10): 1237–52. https://doi.org/10.1038/s41428-022-00669-1.
Chicago author-date (all authors)
Pariy, Igor O., Roman Chernozem, Polina Chernozem, Yulia R. Mukhortova, Andre Skirtach, Vladimir V. Shvartsman, Doru C. Lupascu, Maria A. Surmeneva, Sanjay Mathur, and Roman A. Surmenev. 2022. “Hybrid Biodegradable Electrospun Scaffolds Based on Poly(l-Lactic Acid) and Reduced Graphene Oxide with Improved Piezoelectric Response.” POLYMER JOURNAL 54 (10): 1237–1252. doi:10.1038/s41428-022-00669-1.
Vancouver
1.
Pariy IO, Chernozem R, Chernozem P, Mukhortova YR, Skirtach A, Shvartsman VV, et al. Hybrid biodegradable electrospun scaffolds based on poly(l-lactic acid) and reduced graphene oxide with improved piezoelectric response. POLYMER JOURNAL. 2022;54(10):1237–52.
IEEE
[1]
I. O. Pariy et al., “Hybrid biodegradable electrospun scaffolds based on poly(l-lactic acid) and reduced graphene oxide with improved piezoelectric response,” POLYMER JOURNAL, vol. 54, no. 10, pp. 1237–1252, 2022.
@article{01GQHHH09TYQ7NG8EY9RSCV1GD,
  abstract     = {{Piezoelectric poly-L-lactide (PLLA) is a biodegradable polymer used in various biomedical applications. However, tailoring and controlling the structure of PLLA to enhance its piezoelectric response remains a challenge. In this work, extensive characterization was performed to reveal the effect of the reduced graphene oxide (rGO) content (0.2, 0.7, and 1.0 wt%) on the morphology, structure, thermal and piezoelectric behavior of PLLA scaffolds. Randomly oriented homogeneous fibers and a quasi-amorphous structure for pure PLLA and hybrid PLLA-rGO scaffolds were revealed. The addition of rGO affected the molecular structure of the PLLA scaffolds: for example, the number of polar C=O functional groups was increased. Increasing the content of rGO to 1 wt% resulted in decreased glass transition and melting temperatures and increased the degree of crystallinity of the scaffolds. The addition of 0.2 wt% rGO enhanced the effective local vertical and lateral piezoresponses by 2.3 and 15.4 times, respectively, in comparison with pure PLLA fibers. The presence of the shear piezoelectric alpha-phase (P2(1)2(1)2(1)) in uniaxially oriented PLLA fibers and C=O bond rotation in the polymer chains explained the observed piezoresponse. Thus, this study revealed routes to prepare hybrid biodegradable scaffolds with enhanced piezoresponse for tissue engineering applications.}},
  author       = {{Pariy, Igor O. and Chernozem, Roman and Chernozem, Polina and  Mukhortova, Yulia R. and Skirtach, Andre and  Shvartsman, Vladimir V. and  Lupascu, Doru C. and  Surmeneva, Maria A. and  Mathur, Sanjay and  Surmenev, Roman A.}},
  issn         = {{0032-3896}},
  journal      = {{POLYMER JOURNAL}},
  keywords     = {{RING-OPENING POLYMERIZATION,DOUBLE-MELTING BEHAVIOR,CRYSTAL-STRUCTURE,LACTIC-ACID,PHYSICAL-PROPERTIES,POLY(LACTIC ACID),X-RAY,CRYSTALLIZATION,KINETICS,BONE}},
  language     = {{eng}},
  number       = {{10}},
  pages        = {{1237--1252}},
  title        = {{Hybrid biodegradable electrospun scaffolds based on poly(l-lactic acid) and reduced graphene oxide with improved piezoelectric response}},
  url          = {{http://dx.doi.org/10.1038/s41428-022-00669-1}},
  volume       = {{54}},
  year         = {{2022}},
}

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