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New all-nanoparticle microcapsules for ultrasound release and laser remote killing of cancer cells

Jie Li (UGent) , Louis Van der Meeren (UGent) , Joost Verduijn (UGent) , Bogdan Parakhonskiy (UGent) and Andre Skirtach (UGent)
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Abstract
Being extra strong but super easy to break - entities with such properties would be desired for many applications, particularly in drug delivery, where polyelectrolyte multilayer capsules took a prominent place due to appli-cations in catalysis, intracellular delivery, and carriers of biomolecules and enzymes. Assembly of such capsules has been typically performed either by using polymers or a mixture of polymers and nanoparticles, which facilitated improvement of mechanical properties. In this work, we have assembled a new type of microcapsules, where multilayers are constructed solely by using nanoparticles in all layers. X-ray diffraction (XRD) studies confirmed the dissolution of calcium carbonate, while mechanical properties of such capsules probed by atomic force microscopy (AFM) reveal an essential increase in the stiffness and density in the walls. Dual functionality of such new capsules has been achieved by actions of ultrasound and laser. Since ultrasound acts more effectively on denser objects, low intensity (below 1 W/cm2) of ultrasound has been used to enable release of encapsulated content. Laser has been used to illuminate microcapsules located in cells and effective killing of cancer cells was achieved. Further applications of the assembled microcapsules are expected in conducting catalytic reactions and biomedicine.
Keywords
Polymers, Microcapsules, Nanoparticles, Layer-by-Layer, Cells

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MLA
Li, Jie, et al. “New All-Nanoparticle Microcapsules for Ultrasound Release and Laser Remote Killing of Cancer Cells.” MATERIALS TODAY COMMUNICATIONS, vol. 33, 2022, doi:10.1016/j.mtcomm.2022.104287.
APA
Li, J., Van der Meeren, L., Verduijn, J., Parakhonskiy, B., & Skirtach, A. (2022). New all-nanoparticle microcapsules for ultrasound release and laser remote killing of cancer cells. MATERIALS TODAY COMMUNICATIONS, 33. https://doi.org/10.1016/j.mtcomm.2022.104287
Chicago author-date
Li, Jie, Louis Van der Meeren, Joost Verduijn, Bogdan Parakhonskiy, and Andre Skirtach. 2022. “New All-Nanoparticle Microcapsules for Ultrasound Release and Laser Remote Killing of Cancer Cells.” MATERIALS TODAY COMMUNICATIONS 33. https://doi.org/10.1016/j.mtcomm.2022.104287.
Chicago author-date (all authors)
Li, Jie, Louis Van der Meeren, Joost Verduijn, Bogdan Parakhonskiy, and Andre Skirtach. 2022. “New All-Nanoparticle Microcapsules for Ultrasound Release and Laser Remote Killing of Cancer Cells.” MATERIALS TODAY COMMUNICATIONS 33. doi:10.1016/j.mtcomm.2022.104287.
Vancouver
1.
Li J, Van der Meeren L, Verduijn J, Parakhonskiy B, Skirtach A. New all-nanoparticle microcapsules for ultrasound release and laser remote killing of cancer cells. MATERIALS TODAY COMMUNICATIONS. 2022;33.
IEEE
[1]
J. Li, L. Van der Meeren, J. Verduijn, B. Parakhonskiy, and A. Skirtach, “New all-nanoparticle microcapsules for ultrasound release and laser remote killing of cancer cells,” MATERIALS TODAY COMMUNICATIONS, vol. 33, 2022.
@article{01GQHGPVTGS1077Y7H150H1DZK,
  abstract     = {{Being extra strong but super easy to break - entities with such properties would be desired for many applications, particularly in drug delivery, where polyelectrolyte multilayer capsules took a prominent place due to appli-cations in catalysis, intracellular delivery, and carriers of biomolecules and enzymes. Assembly of such capsules has been typically performed either by using polymers or a mixture of polymers and nanoparticles, which facilitated improvement of mechanical properties. In this work, we have assembled a new type of microcapsules, where multilayers are constructed solely by using nanoparticles in all layers. X-ray diffraction (XRD) studies confirmed the dissolution of calcium carbonate, while mechanical properties of such capsules probed by atomic force microscopy (AFM) reveal an essential increase in the stiffness and density in the walls. Dual functionality of such new capsules has been achieved by actions of ultrasound and laser. Since ultrasound acts more effectively on denser objects, low intensity (below 1 W/cm2) of ultrasound has been used to enable release of encapsulated content. Laser has been used to illuminate microcapsules located in cells and effective killing of cancer cells was achieved. Further applications of the assembled microcapsules are expected in conducting catalytic reactions and biomedicine.}},
  articleno    = {{104287}},
  author       = {{Li, Jie and Van der Meeren, Louis and Verduijn, Joost and Parakhonskiy, Bogdan and Skirtach, Andre}},
  issn         = {{2352-4928}},
  journal      = {{MATERIALS TODAY COMMUNICATIONS}},
  keywords     = {{Polymers,Microcapsules,Nanoparticles,Layer-by-Layer,Cells}},
  language     = {{eng}},
  pages        = {{7}},
  title        = {{New all-nanoparticle microcapsules for ultrasound release and laser remote killing of cancer cells}},
  url          = {{http://dx.doi.org/10.1016/j.mtcomm.2022.104287}},
  volume       = {{33}},
  year         = {{2022}},
}

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