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Personalisation of plantarflexor musculotendon model parameters in children with cerebral palsy

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Abstract
Neuromusculoskeletal models can be used to evaluate aberrant muscle function in cerebral palsy (CP), for example by estimating muscle and joint contact forces during gait. However, to be accurate, models should include representative musculotendon parameters. We aimed to estimate personalised parameters that capture the mechanical behaviour of the plantarflexors in children with CP and typically developing (TD) children. Ankle angle (using motion capture), torque (using a load-cell), and medial gastrocnemius fascicle lengths (using ultrasound) were measured during slow passive ankle dorsiflexion rotation for thirteen children with spastic CP and thirteen TD children. Per subject, the measured rotation was input to a scaled OpenSim model to simulate the torque and fascicle length output. Musculotendon model parameters were personalised by the best match between simulated and experimental torque-angle and fascicle length-angle curves according to a least-squares fit. Personalised tendon slack lengths were significantly longer and optimal fibre lengths significantly shorter in CP than model defaults and than in TD. Personalised tendon compliance was substantially higher in both groups compared to the model default. The presented method to personalise musculotendon parameters will likely yield more accurate simulations of subject-specific muscle mechanics, to help us understand the effects of altered musculotendon properties in CP.
Keywords
Biomedical Engineering, Biomechanical simulation, Muscle mechanics, Triceps surae, Calf muscles, Achilles tendon, Ultrasound, Contracture, Subject specific, Neuromusculoskeletal modelling, OpenSim, ACHILLES-TENDON COMPLIANCE, MEDIAL GASTROCNEMIUS, MECHANICAL-PROPERTIES, FASCICLE LENGTH, YOUNG-ADULTS, LOWER-LIMB, MUSCLE, ARCHITECTURE, SIMULATIONS, SENSITIVITY

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MLA
Veerkamp, Kirsten, et al. “Personalisation of Plantarflexor Musculotendon Model Parameters in Children with Cerebral Palsy.” ANNALS OF BIOMEDICAL ENGINEERING, vol. 51, no. 5, 2023, pp. 938–50, doi:10.1007/s10439-022-03107-8.
APA
Veerkamp, K., van der Krogt, M. M., Harlaar, J., O’Brien, T. D., Kalkman, B., Seth, A., & Bar-On, L. (2023). Personalisation of plantarflexor musculotendon model parameters in children with cerebral palsy. ANNALS OF BIOMEDICAL ENGINEERING, 51(5), 938–950. https://doi.org/10.1007/s10439-022-03107-8
Chicago author-date
Veerkamp, Kirsten, Marjolein M. van der Krogt, Jaap Harlaar, Thomas D. O’Brien, Barbara Kalkman, Ajay Seth, and Lynn Bar-On. 2023. “Personalisation of Plantarflexor Musculotendon Model Parameters in Children with Cerebral Palsy.” ANNALS OF BIOMEDICAL ENGINEERING 51 (5): 938–50. https://doi.org/10.1007/s10439-022-03107-8.
Chicago author-date (all authors)
Veerkamp, Kirsten, Marjolein M. van der Krogt, Jaap Harlaar, Thomas D. O’Brien, Barbara Kalkman, Ajay Seth, and Lynn Bar-On. 2023. “Personalisation of Plantarflexor Musculotendon Model Parameters in Children with Cerebral Palsy.” ANNALS OF BIOMEDICAL ENGINEERING 51 (5): 938–950. doi:10.1007/s10439-022-03107-8.
Vancouver
1.
Veerkamp K, van der Krogt MM, Harlaar J, O’Brien TD, Kalkman B, Seth A, et al. Personalisation of plantarflexor musculotendon model parameters in children with cerebral palsy. ANNALS OF BIOMEDICAL ENGINEERING. 2023;51(5):938–50.
IEEE
[1]
K. Veerkamp et al., “Personalisation of plantarflexor musculotendon model parameters in children with cerebral palsy,” ANNALS OF BIOMEDICAL ENGINEERING, vol. 51, no. 5, pp. 938–950, 2023.
@article{01GQG5N27BRVD3V58KA7W65SZE,
  abstract     = {{Neuromusculoskeletal models can be used to evaluate aberrant muscle function in cerebral palsy (CP), for example by estimating muscle and joint contact forces during gait. However, to be accurate, models should include representative musculotendon parameters. We aimed to estimate personalised parameters that capture the mechanical behaviour of the plantarflexors in children with CP and typically developing (TD) children. Ankle angle (using motion capture), torque (using a load-cell), and medial gastrocnemius fascicle lengths (using ultrasound) were measured during slow passive ankle dorsiflexion rotation for thirteen children with spastic CP and thirteen TD children. Per subject, the measured rotation was input to a scaled OpenSim model to simulate the torque and fascicle length output. Musculotendon model parameters were personalised by the best match between simulated and experimental torque-angle and fascicle length-angle curves according to a least-squares fit. Personalised tendon slack lengths were significantly longer and optimal fibre lengths significantly shorter in CP than model defaults and than in TD. Personalised tendon compliance was substantially higher in both groups compared to the model default. The presented method to personalise musculotendon parameters will likely yield more accurate simulations of subject-specific muscle mechanics, to help us understand the effects of altered musculotendon properties in CP.}},
  author       = {{Veerkamp, Kirsten and van der Krogt, Marjolein M. and Harlaar, Jaap and O’Brien, Thomas D. and Kalkman, Barbara and Seth, Ajay and Bar-On, Lynn}},
  issn         = {{0090-6964}},
  journal      = {{ANNALS OF BIOMEDICAL ENGINEERING}},
  keywords     = {{Biomedical Engineering,Biomechanical simulation,Muscle mechanics,Triceps surae,Calf muscles,Achilles tendon,Ultrasound,Contracture,Subject specific,Neuromusculoskeletal modelling,OpenSim,ACHILLES-TENDON COMPLIANCE,MEDIAL GASTROCNEMIUS,MECHANICAL-PROPERTIES,FASCICLE LENGTH,YOUNG-ADULTS,LOWER-LIMB,MUSCLE,ARCHITECTURE,SIMULATIONS,SENSITIVITY}},
  language     = {{eng}},
  number       = {{5}},
  pages        = {{938--950}},
  title        = {{Personalisation of plantarflexor musculotendon model parameters in children with cerebral palsy}},
  url          = {{http://doi.org/10.1007/s10439-022-03107-8}},
  volume       = {{51}},
  year         = {{2023}},
}

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