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earlyMYCO : a pilot mother-child cohort study to assess early-life exposure to mycotoxins-challenges and lessons learned

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Abstract
Early-life exposure occurs during gestation through transfer to the fetus and later, during lactation. Recent monitoring data revealed that the Portuguese population is exposed to mycotoxins, including young children. This study aimed to develop a pilot study to assess the early-life exposure to mycotoxins through a mother-child cohort, and to identify the associated challenges. Participants were recruited during pregnancy (1st trimester) and followed-up in three moments of observation: 2nd trimester of pregnancy (mother), and 1st and 6th month of the child's life (mother and child), with the collection of biological samples and sociodemographic and food consumption data. The earlyMYCO pilot study enrolled 19 mother-child pairs. The analysis of biological samples from participants revealed the presence of 4 out of 15 and 5 out of 18 mycotoxins' biomarkers of exposure in urine and breast milk samples, respectively. The main aspects identified as contributors for the successful development of the cohort were the multidisciplinary and dedicated team members in healthcare units, reduced burden of participation, and the availability of healthcare units for the implementation of the fieldwork. Challenges faced, lessons learned, and suggestions were discussed as a contribution for the development of further studies in this area.
Keywords
early-life exposure, birth cohorts, mycotoxins, exposome, Portugal, MULTIPLE MYCOTOXINS, RISK-ASSESSMENT, EXPOSOME, PROFILE

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MLA
Martins, Carla, et al. “EarlyMYCO : A Pilot Mother-Child Cohort Study to Assess Early-Life Exposure to Mycotoxins-Challenges and Lessons Learned.” INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH, vol. 19, no. 13, 2022, doi:10.3390/ijerph19137716.
APA
Martins, C., Assuncao, R., Costa, A., Serrano, D., Visintin, L., De Boevre, M., … Nunes, C. (2022). earlyMYCO : a pilot mother-child cohort study to assess early-life exposure to mycotoxins-challenges and lessons learned. INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH, 19(13). https://doi.org/10.3390/ijerph19137716
Chicago author-date
Martins, Carla, Ricardo Assuncao, Ana Costa, Debora Serrano, Lia Visintin, Marthe De Boevre, Carl Lachat, et al. 2022. “EarlyMYCO : A Pilot Mother-Child Cohort Study to Assess Early-Life Exposure to Mycotoxins-Challenges and Lessons Learned.” INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH 19 (13). https://doi.org/10.3390/ijerph19137716.
Chicago author-date (all authors)
Martins, Carla, Ricardo Assuncao, Ana Costa, Debora Serrano, Lia Visintin, Marthe De Boevre, Carl Lachat, Arnau Vidal Corominas, Sarah De Saeger, Sonia Namorado, Cristina Vidigal, Elisabete Almeida, Paula Alvito, and Carla Nunes. 2022. “EarlyMYCO : A Pilot Mother-Child Cohort Study to Assess Early-Life Exposure to Mycotoxins-Challenges and Lessons Learned.” INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH 19 (13). doi:10.3390/ijerph19137716.
Vancouver
1.
Martins C, Assuncao R, Costa A, Serrano D, Visintin L, De Boevre M, et al. earlyMYCO : a pilot mother-child cohort study to assess early-life exposure to mycotoxins-challenges and lessons learned. INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH. 2022;19(13).
IEEE
[1]
C. Martins et al., “earlyMYCO : a pilot mother-child cohort study to assess early-life exposure to mycotoxins-challenges and lessons learned,” INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH, vol. 19, no. 13, 2022.
@article{01GPK9Q46MN8SK7HZMM1RKE0R2,
  abstract     = {{Early-life exposure occurs during gestation through transfer to the fetus and later, during lactation. Recent monitoring data revealed that the Portuguese population is exposed to mycotoxins, including young children. This study aimed to develop a pilot study to assess the early-life exposure to mycotoxins through a mother-child cohort, and to identify the associated challenges. Participants were recruited during pregnancy (1st trimester) and followed-up in three moments of observation: 2nd trimester of pregnancy (mother), and 1st and 6th month of the child's life (mother and child), with the collection of biological samples and sociodemographic and food consumption data. The earlyMYCO pilot study enrolled 19 mother-child pairs. The analysis of biological samples from participants revealed the presence of 4 out of 15 and 5 out of 18 mycotoxins' biomarkers of exposure in urine and breast milk samples, respectively. The main aspects identified as contributors for the successful development of the cohort were the multidisciplinary and dedicated team members in healthcare units, reduced burden of participation, and the availability of healthcare units for the implementation of the fieldwork. Challenges faced, lessons learned, and suggestions were discussed as a contribution for the development of further studies in this area.}},
  articleno    = {{7716}},
  author       = {{Martins, Carla and  Assuncao, Ricardo and  Costa, Ana and  Serrano, Debora and Visintin, Lia and De Boevre, Marthe and Lachat, Carl and Vidal Corominas, Arnau and De Saeger, Sarah and Namorado, Sonia and  Vidigal, Cristina and  Almeida, Elisabete and  Alvito, Paula and  Nunes, Carla}},
  issn         = {{1660-4601}},
  journal      = {{INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH}},
  keywords     = {{early-life exposure,birth cohorts,mycotoxins,exposome,Portugal,MULTIPLE MYCOTOXINS,RISK-ASSESSMENT,EXPOSOME,PROFILE}},
  language     = {{eng}},
  number       = {{13}},
  pages        = {{15}},
  title        = {{earlyMYCO : a pilot mother-child cohort study to assess early-life exposure to mycotoxins-challenges and lessons learned}},
  url          = {{http://doi.org/10.3390/ijerph19137716}},
  volume       = {{19}},
  year         = {{2022}},
}

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