Advanced search
2 files | 8.43 MB Add to list

Choroid plexus-derived extracellular vesicles exhibit brain targeting characteristics

(2022) BIOMATERIALS. 290.
Author
Organization
Project
Abstract
The brain is protected against invading organisms and other unwanted substances by tightly regulated barriers. However, these central nervous system (CNS) barriers impede the delivery of drugs into the brain via the blood circulation and are therefore considered major hurdles in the treatment of neurological disorders. Consequently, there is a high need for efficient delivery systems that are able to cross these strict barriers. While most research focuses on the blood-brain barrier (BBB), the design of drug delivery platforms that are able to cross the bloodcerebrospinal fluid (CSF) barrier, formed by a single layer of choroid plexus epithelial cells, remains a largely unexplored domain. The discovery that extracellular vesicles (EVs) make up a natural mechanism for information transfer between cells and across cell layers, has stimulated interest in their potential use as drug delivery platform. Here, we report that choroid plexus epithelial cell-derived EVs exhibit the capacity to home to the brain after peripheral administration. Moreover, these vesicles are able to functionally deliver cargo into the brain. Our findings underline the therapeutic potential of choroid plexus-derived EVs as a brain drug delivery vehicle via targeting of the blood-CSF interface.
Keywords
Extracellular vesicles (EVs), Blood -cerebrospinal fluid (CSF) barrier, Brain delivery, Brain barriers, DRUG-DELIVERY SYSTEMS, BLOOD-BRAIN, FOLATE RECEPTOR, TRANSFERRIN RECEPTOR, EXOSOMES, BARRIER, TRANSPORT, INJURY, COMMUNICATION, LOCALIZATION

Downloads

  • (...).pdf
    • full text (Published version)
    • |
    • UGent only
    • |
    • PDF
    • |
    • 5.56 MB
  • Marie J Pauwels et al Accepted Manuscript.pdf
    • full text (Accepted manuscript)
    • |
    • open access
    • |
    • PDF
    • |
    • 2.87 MB

Citation

Please use this url to cite or link to this publication:

MLA
Pauwels, Marie, et al. “Choroid Plexus-Derived Extracellular Vesicles Exhibit Brain Targeting Characteristics.” BIOMATERIALS, vol. 290, 2022, doi:10.1016/j.biomaterials.2022.121830.
APA
Pauwels, M., Xie, J., Ceroi, A., Balusu, S., Castelein, J., Van Wonterghem, E., … Vandenbroucke, R. (2022). Choroid plexus-derived extracellular vesicles exhibit brain targeting characteristics. BIOMATERIALS, 290. https://doi.org/10.1016/j.biomaterials.2022.121830
Chicago author-date
Pauwels, Marie, Junhua Xie, Adam Ceroi, Sriram Balusu, Jonas Castelein, Elien Van Wonterghem, Griet Van Imschoot, et al. 2022. “Choroid Plexus-Derived Extracellular Vesicles Exhibit Brain Targeting Characteristics.” BIOMATERIALS 290. https://doi.org/10.1016/j.biomaterials.2022.121830.
Chicago author-date (all authors)
Pauwels, Marie, Junhua Xie, Adam Ceroi, Sriram Balusu, Jonas Castelein, Elien Van Wonterghem, Griet Van Imschoot, Andrew Ward, Trevelyan R. Menheniott, Oskar Gustafsson, Francis Combes, Samir El Andaloussi, Niek Sanders, Imre Mager, Lien Van Hoecke, and Roosmarijn Vandenbroucke. 2022. “Choroid Plexus-Derived Extracellular Vesicles Exhibit Brain Targeting Characteristics.” BIOMATERIALS 290. doi:10.1016/j.biomaterials.2022.121830.
Vancouver
1.
Pauwels M, Xie J, Ceroi A, Balusu S, Castelein J, Van Wonterghem E, et al. Choroid plexus-derived extracellular vesicles exhibit brain targeting characteristics. BIOMATERIALS. 2022;290.
IEEE
[1]
M. Pauwels et al., “Choroid plexus-derived extracellular vesicles exhibit brain targeting characteristics,” BIOMATERIALS, vol. 290, 2022.
@article{01GPB9254PVGVYJN1ES6BJW2V8,
  abstract     = {{The brain is protected against invading organisms and other unwanted substances by tightly regulated barriers. However, these central nervous system (CNS) barriers impede the delivery of drugs into the brain via the blood circulation and are therefore considered major hurdles in the treatment of neurological disorders. Consequently, there is a high need for efficient delivery systems that are able to cross these strict barriers. While most research focuses on the blood-brain barrier (BBB), the design of drug delivery platforms that are able to cross the bloodcerebrospinal fluid (CSF) barrier, formed by a single layer of choroid plexus epithelial cells, remains a largely unexplored domain. The discovery that extracellular vesicles (EVs) make up a natural mechanism for information transfer between cells and across cell layers, has stimulated interest in their potential use as drug delivery platform. Here, we report that choroid plexus epithelial cell-derived EVs exhibit the capacity to home to the brain after peripheral administration. Moreover, these vesicles are able to functionally deliver cargo into the brain. Our findings underline the therapeutic potential of choroid plexus-derived EVs as a brain drug delivery vehicle via targeting of the blood-CSF interface.}},
  articleno    = {{121830}},
  author       = {{Pauwels, Marie and Xie, Junhua and Ceroi, Adam and Balusu, Sriram and Castelein, Jonas and Van Wonterghem, Elien and Van Imschoot, Griet and  Ward, Andrew and  Menheniott, Trevelyan R. and  Gustafsson, Oskar and  Combes, Francis and  El Andaloussi, Samir and Sanders, Niek and  Mager, Imre and Van Hoecke, Lien and Vandenbroucke, Roosmarijn}},
  issn         = {{0142-9612}},
  journal      = {{BIOMATERIALS}},
  keywords     = {{Extracellular vesicles (EVs),Blood -cerebrospinal fluid (CSF) barrier,Brain delivery,Brain barriers,DRUG-DELIVERY SYSTEMS,BLOOD-BRAIN,FOLATE RECEPTOR,TRANSFERRIN RECEPTOR,EXOSOMES,BARRIER,TRANSPORT,INJURY,COMMUNICATION,LOCALIZATION}},
  language     = {{eng}},
  title        = {{Choroid plexus-derived extracellular vesicles exhibit brain targeting characteristics}},
  url          = {{http://doi.org/10.1016/j.biomaterials.2022.121830}},
  volume       = {{290}},
  year         = {{2022}},
}

Altmetric
View in Altmetric
Web of Science
Times cited: