Choroid plexus-derived extracellular vesicles exhibit brain targeting characteristics
- Author
- Marie Pauwels, Junhua Xie, Adam Ceroi (UGent) , Sriram Balusu, Jonas Castelein (UGent) , Elien Van Wonterghem (UGent) , Griet Van Imschoot (UGent) , Andrew Ward, Trevelyan R. Menheniott, Oskar Gustafsson, Francis Combes, Samir El Andaloussi, Niek Sanders (UGent) , Imre Mager, Lien Van Hoecke (UGent) and Roosmarijn Vandenbroucke (UGent)
- Organization
- Project
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- Extracellular vesicle (EV) transport across the brain barriers: from mechanistic and biological insights towards strategies for delivery of therapeutics to the brain.
- Exploring the therapeutic applicability of extracellular vesicles and their natural mechanism of blood-cerebrospinal fluid barrier crossing as an innovative drug delivery strategy to the brain.
- Crossing the barrier: bringing the biologics revolution to the brain
- Abstract
- The brain is protected against invading organisms and other unwanted substances by tightly regulated barriers. However, these central nervous system (CNS) barriers impede the delivery of drugs into the brain via the blood circulation and are therefore considered major hurdles in the treatment of neurological disorders. Consequently, there is a high need for efficient delivery systems that are able to cross these strict barriers. While most research focuses on the blood-brain barrier (BBB), the design of drug delivery platforms that are able to cross the bloodcerebrospinal fluid (CSF) barrier, formed by a single layer of choroid plexus epithelial cells, remains a largely unexplored domain. The discovery that extracellular vesicles (EVs) make up a natural mechanism for information transfer between cells and across cell layers, has stimulated interest in their potential use as drug delivery platform. Here, we report that choroid plexus epithelial cell-derived EVs exhibit the capacity to home to the brain after peripheral administration. Moreover, these vesicles are able to functionally deliver cargo into the brain. Our findings underline the therapeutic potential of choroid plexus-derived EVs as a brain drug delivery vehicle via targeting of the blood-CSF interface.
- Keywords
- Extracellular vesicles (EVs), Blood -cerebrospinal fluid (CSF) barrier, Brain delivery, Brain barriers, DRUG-DELIVERY SYSTEMS, BLOOD-BRAIN, FOLATE RECEPTOR, TRANSFERRIN RECEPTOR, EXOSOMES, BARRIER, TRANSPORT, INJURY, COMMUNICATION, LOCALIZATION
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Citation
Please use this url to cite or link to this publication: http://hdl.handle.net/1854/LU-01GPB9254PVGVYJN1ES6BJW2V8
- MLA
- Pauwels, Marie, et al. “Choroid Plexus-Derived Extracellular Vesicles Exhibit Brain Targeting Characteristics.” BIOMATERIALS, vol. 290, 2022, doi:10.1016/j.biomaterials.2022.121830.
- APA
- Pauwels, M., Xie, J., Ceroi, A., Balusu, S., Castelein, J., Van Wonterghem, E., … Vandenbroucke, R. (2022). Choroid plexus-derived extracellular vesicles exhibit brain targeting characteristics. BIOMATERIALS, 290. https://doi.org/10.1016/j.biomaterials.2022.121830
- Chicago author-date
- Pauwels, Marie, Junhua Xie, Adam Ceroi, Sriram Balusu, Jonas Castelein, Elien Van Wonterghem, Griet Van Imschoot, et al. 2022. “Choroid Plexus-Derived Extracellular Vesicles Exhibit Brain Targeting Characteristics.” BIOMATERIALS 290. https://doi.org/10.1016/j.biomaterials.2022.121830.
- Chicago author-date (all authors)
- Pauwels, Marie, Junhua Xie, Adam Ceroi, Sriram Balusu, Jonas Castelein, Elien Van Wonterghem, Griet Van Imschoot, Andrew Ward, Trevelyan R. Menheniott, Oskar Gustafsson, Francis Combes, Samir El Andaloussi, Niek Sanders, Imre Mager, Lien Van Hoecke, and Roosmarijn Vandenbroucke. 2022. “Choroid Plexus-Derived Extracellular Vesicles Exhibit Brain Targeting Characteristics.” BIOMATERIALS 290. doi:10.1016/j.biomaterials.2022.121830.
- Vancouver
- 1.Pauwels M, Xie J, Ceroi A, Balusu S, Castelein J, Van Wonterghem E, et al. Choroid plexus-derived extracellular vesicles exhibit brain targeting characteristics. BIOMATERIALS. 2022;290.
- IEEE
- [1]M. Pauwels et al., “Choroid plexus-derived extracellular vesicles exhibit brain targeting characteristics,” BIOMATERIALS, vol. 290, 2022.
@article{01GPB9254PVGVYJN1ES6BJW2V8,
abstract = {{The brain is protected against invading organisms and other unwanted substances by tightly regulated barriers. However, these central nervous system (CNS) barriers impede the delivery of drugs into the brain via the blood circulation and are therefore considered major hurdles in the treatment of neurological disorders. Consequently, there is a high need for efficient delivery systems that are able to cross these strict barriers. While most research focuses on the blood-brain barrier (BBB), the design of drug delivery platforms that are able to cross the bloodcerebrospinal fluid (CSF) barrier, formed by a single layer of choroid plexus epithelial cells, remains a largely unexplored domain. The discovery that extracellular vesicles (EVs) make up a natural mechanism for information transfer between cells and across cell layers, has stimulated interest in their potential use as drug delivery platform. Here, we report that choroid plexus epithelial cell-derived EVs exhibit the capacity to home to the brain after peripheral administration. Moreover, these vesicles are able to functionally deliver cargo into the brain. Our findings underline the therapeutic potential of choroid plexus-derived EVs as a brain drug delivery vehicle via targeting of the blood-CSF interface.}},
articleno = {{121830}},
author = {{Pauwels, Marie and Xie, Junhua and Ceroi, Adam and Balusu, Sriram and Castelein, Jonas and Van Wonterghem, Elien and Van Imschoot, Griet and Ward, Andrew and Menheniott, Trevelyan R. and Gustafsson, Oskar and Combes, Francis and El Andaloussi, Samir and Sanders, Niek and Mager, Imre and Van Hoecke, Lien and Vandenbroucke, Roosmarijn}},
issn = {{0142-9612}},
journal = {{BIOMATERIALS}},
keywords = {{Extracellular vesicles (EVs),Blood -cerebrospinal fluid (CSF) barrier,Brain delivery,Brain barriers,DRUG-DELIVERY SYSTEMS,BLOOD-BRAIN,FOLATE RECEPTOR,TRANSFERRIN RECEPTOR,EXOSOMES,BARRIER,TRANSPORT,INJURY,COMMUNICATION,LOCALIZATION}},
language = {{eng}},
title = {{Choroid plexus-derived extracellular vesicles exhibit brain targeting characteristics}},
url = {{http://doi.org/10.1016/j.biomaterials.2022.121830}},
volume = {{290}},
year = {{2022}},
}
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