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Development of a genetic risk score to predict the risk of hypertension in European adolescents from the HELENA study

Gloria Pérez-Gimeno, Miguel Seral-Cortes, Sergio Sabroso-Lasa, Luis Mariano Esteban, Empar Lurbe, Laurent Béghin, Frederic Gottrand, Aline Meirhaeghe, Manon Muntaner, Anthony Kafatos, et al.
(2022) Research Square.
Author
Organization
Abstract
Background Several single nucleotide polymorphisms (SNPs) are associated with blood pressure (BP) levels. A combination of SNPs, forming a genetic risk score (GRS) could be considered a useful genetic tool to identify individuals at risk of developing hypertension from early stages in life. Therefore, the study aims to predict the genetic predisposition to hypertension in European adolescents from a GRS. Methods A total of 869 adolescents (53% female), aged 12.5–17.5, were included from the “Healthy Lifestyle in Europe by Nutrition in Adolescence” (HELENA) cross-sectional study. The sample was divided into altered (≥ 130 mmHg for systolic and/or ≥ 80 mmHg for diastolic) or normal BP. Results From 1534 SNPs available, An initial screening of SNPs univariately associated with BP (p < 0.10) was established, to finally obtain a number of 16 SNPs significantly associated with BP (p < 0.05) in the multivariate model. Both unweighted GRS (uGRS) and weighted GRS (wGRS) were associated with altered BP. The area under the curve was explored using ten-fold internal cross-validation for uGRS (0.796) and wGRS (0.803). Further covariates were added to obtain a higher predictive ability. Conclusions Both GRSs, could be useful to evaluate the genetic predisposition to hypertension in European adolescents.

Citation

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MLA
Pérez-Gimeno, Gloria, et al. “Development of a Genetic Risk Score to Predict the Risk of Hypertension in European Adolescents from the HELENA Study.” Research Square, Research Square Platform LLC, 2022, doi:10.21203/rs.3.rs-1978509/v2.
APA
Pérez-Gimeno, G., Seral-Cortes, M., Sabroso-Lasa, S., Esteban, L. M., Lurbe, E., Béghin, L., … Moreno, L. (2022). Development of a genetic risk score to predict the risk of hypertension in European adolescents from the HELENA study. https://doi.org/10.21203/rs.3.rs-1978509/v2
Chicago author-date
Pérez-Gimeno, Gloria, Miguel Seral-Cortes, Sergio Sabroso-Lasa, Luis Mariano Esteban, Empar Lurbe, Laurent Béghin, Frederic Gottrand, et al. 2022. “Development of a Genetic Risk Score to Predict the Risk of Hypertension in European Adolescents from the HELENA Study.” Research Square. Research Square Platform LLC. https://doi.org/10.21203/rs.3.rs-1978509/v2.
Chicago author-date (all authors)
Pérez-Gimeno, Gloria, Miguel Seral-Cortes, Sergio Sabroso-Lasa, Luis Mariano Esteban, Empar Lurbe, Laurent Béghin, Frederic Gottrand, Aline Meirhaeghe, Manon Muntaner, Anthony Kafatos, Dénes Molnár, Catherine Leclercq, Kurt Widhalm, Mathilde Kersting, Esther Nova, Diego F. Salazar-Tortosa, Marcela Gonzalez-Gross, Christina Breidenassel, Kathrin Sinningen, Thaïs De Ruyter, Idoia Labayen, Azahara I. Rupérez, Gloria Bueno-Lozano, and Luis Moreno. 2022. “Development of a Genetic Risk Score to Predict the Risk of Hypertension in European Adolescents from the HELENA Study.” Research Square. Research Square Platform LLC. doi:10.21203/rs.3.rs-1978509/v2.
Vancouver
1.
Pérez-Gimeno G, Seral-Cortes M, Sabroso-Lasa S, Esteban LM, Lurbe E, Béghin L, et al. Development of a genetic risk score to predict the risk of hypertension in European adolescents from the HELENA study. Research Square. Research Square Platform LLC; 2022.
IEEE
[1]
G. Pérez-Gimeno et al., “Development of a genetic risk score to predict the risk of hypertension in European adolescents from the HELENA study,” Research Square. Research Square Platform LLC, 2022.
@misc{01GNVH0QBZPA31J4XT732FRJWD,
  abstract     = {{Background
Several single nucleotide polymorphisms (SNPs) are associated with blood pressure (BP) levels. A combination of SNPs, forming a genetic risk score (GRS) could be considered a useful genetic tool to identify individuals at risk of developing hypertension from early stages in life. Therefore, the study aims to predict the genetic predisposition to hypertension in European adolescents from a GRS.

Methods
A total of 869 adolescents (53% female), aged 12.5–17.5, were included from the “Healthy Lifestyle in Europe by Nutrition in Adolescence” (HELENA) cross-sectional study. The sample was divided into altered (≥ 130 mmHg for systolic and/or ≥ 80 mmHg for diastolic) or normal BP.

Results
From 1534 SNPs available, An initial screening of SNPs univariately associated with BP (p < 0.10) was established, to finally obtain a number of 16 SNPs significantly associated with BP (p < 0.05) in the multivariate model. Both unweighted GRS (uGRS) and weighted GRS (wGRS) were associated with altered BP. The area under the curve was explored using ten-fold internal cross-validation for uGRS (0.796) and wGRS (0.803). Further covariates were added to obtain a higher predictive ability.

Conclusions
Both GRSs, could be useful to evaluate the genetic predisposition to hypertension in European adolescents.}},
  author       = {{Pérez-Gimeno, Gloria and Seral-Cortes, Miguel and Sabroso-Lasa, Sergio and Esteban, Luis Mariano and Lurbe, Empar and Béghin, Laurent and Gottrand, Frederic and Meirhaeghe, Aline and Muntaner, Manon and Kafatos, Anthony and Molnár, Dénes and Leclercq, Catherine and Widhalm, Kurt and Kersting, Mathilde and Nova, Esther and Salazar-Tortosa, Diego F. and Gonzalez-Gross, Marcela and Breidenassel, Christina and Sinningen, Kathrin and De Ruyter, Thaïs and Labayen, Idoia and Rupérez, Azahara I. and Bueno-Lozano, Gloria and Moreno, Luis}},
  language     = {{eng}},
  publisher    = {{Research Square Platform LLC}},
  series       = {{Research Square}},
  title        = {{Development of a genetic risk score to predict the risk of hypertension in European adolescents from the HELENA study}},
  url          = {{http://doi.org/10.21203/rs.3.rs-1978509/v2}},
  year         = {{2022}},
}
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