Association between immunosenescence phenotypes and pre-frailty in older subjects : does cytomegalovirus play a role?

Hung, Cao Dinh; Bautmans, Ivan; Beyer, Ingo; Mets, Tony; Onyema, Oscar Okwudiri; Forti, Louis Nuvagah; Renmans, Wim; Vander Meeren, Sam; Jochmans, Kristin; Vermeiren, Sofie; Vella-Azzopardi, Roberta; Njemini, Rose; Verté, Dominique; Petrovic, Mirko; De Donder, Liesbeth; Kardol, Tinie; Rossi, Gina; Clarys, Peter; Scafoglieri, Aldo; Cattrysse, Eric; de Hert, Paul; Jansen, Bart

Association between immunosenescence phenotypes and pre-frailty in older subjects : does cytomegalovirus play a role?

Cao Dinh Hung, Ivan Bautmans, Ingo Beyer, Tony Mets, Oscar Okwudiri Onyema, Louis Nuvagah Forti, Wim Renmans, Sam Vander Meeren, Kristin Jochmans, Sofie Vermeiren, et al.

(2019) JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES. 74(4). p.480-488

Author

Cao Dinh Hung, Ivan Bautmans, Ingo Beyer, Tony Mets, Oscar Okwudiri Onyema, Louis Nuvagah Forti, Wim Renmans, Sam Vander Meeren, Kristin Jochmans, Sofie Vermeiren, Roberta Vella-Azzopardi, Rose Njemini, Dominique Verté, Mirko Petrovic (UGent) , Liesbeth De Donder, Tinie Kardol, Gina Rossi, Peter Clarys, Aldo Scafoglieri, Eric Cattrysse, Paul de Hert and Bart Jansen

Organization

Department of Internal Medicine and Pediatrics

Abstract

Frailty is highly prevalent in old age and confers an important mortality risk. Although the causes of frailty are multiple, immunosenescence (IS)—predominantly driven by cytomegalovirus (CMV)—has been implicated in its pathophysiology. Thus far, research examining the association between IS and frailty states is sparse and equivocal. On the other hand, evidence is mounting in support of the view that frailty can be reversed, especially for those in the pre-frail stage. Therefore, we aimed to clarify the impact of CMV on IS and its relevance to pre-frailty. One hundred seventy-three persons aged 80 to 99 years were enrolled. Pre-frailty was defined according to Fried’s criteria. Anti-CMV IgG and serum IL-6 were measured using Architect iSystem and Luminex, respectively. T-cell phenotypes were determined using flow cytometry. The prevalence of pre-frailty was 52.6%, increased with age (p = .001), and was greater in men than women (p = .044). No relationship was found between pre-frailty and positive CMV serology. Further, CMV-seropositivity was significantly associated with less naïve cells, more memory and senescence-prone phenotypes (all p < .001). After adjusting for potential confounders, only IL-6, age and sex were predictive of pre-frailty. We conclude that the presence of pre-frailty is independent from CMV infection in very old subjects.

Keywords

Senescence, Inflammation, Lymphocytes, Robust

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Please use this url to cite or link to this publication: http://hdl.handle.net/1854/LU-01GN78CKBAE94BQED3B54EAJDT

MLA: Hung, Cao Dinh, et al. “Association between Immunosenescence Phenotypes and Pre-Frailty in Older Subjects : Does Cytomegalovirus Play a Role?” JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES, vol. 74, no. 4, 2019, pp. 480–88, doi:10.1093/gerona/gly135.
APA: Hung, C. D., Bautmans, I., Beyer, I., Mets, T., Onyema, O. O., Forti, L. N., … Jansen, B. (2019). Association between immunosenescence phenotypes and pre-frailty in older subjects : does cytomegalovirus play a role? JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES, 74(4), 480–488. https://doi.org/10.1093/gerona/gly135
Chicago author-date: Hung, Cao Dinh, Ivan Bautmans, Ingo Beyer, Tony Mets, Oscar Okwudiri Onyema, Louis Nuvagah Forti, Wim Renmans, et al. 2019. “Association between Immunosenescence Phenotypes and Pre-Frailty in Older Subjects : Does Cytomegalovirus Play a Role?” JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES 74 (4): 480–88. https://doi.org/10.1093/gerona/gly135.
Chicago author-date (all authors): Hung, Cao Dinh, Ivan Bautmans, Ingo Beyer, Tony Mets, Oscar Okwudiri Onyema, Louis Nuvagah Forti, Wim Renmans, Sam Vander Meeren, Kristin Jochmans, Sofie Vermeiren, Roberta Vella-Azzopardi, Rose Njemini, Dominique Verté, Mirko Petrovic, Liesbeth De Donder, Tinie Kardol, Gina Rossi, Peter Clarys, Aldo Scafoglieri, Eric Cattrysse, Paul de Hert, and Bart Jansen. 2019. “Association between Immunosenescence Phenotypes and Pre-Frailty in Older Subjects : Does Cytomegalovirus Play a Role?” JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES 74 (4): 480–488. doi:10.1093/gerona/gly135.
Vancouver: 1.
Hung CD, Bautmans I, Beyer I, Mets T, Onyema OO, Forti LN, et al. Association between immunosenescence phenotypes and pre-frailty in older subjects : does cytomegalovirus play a role? JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES. 2019;74(4):480–8.
IEEE: [1]
C. D. Hung et al., “Association between immunosenescence phenotypes and pre-frailty in older subjects : does cytomegalovirus play a role?,” JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES, vol. 74, no. 4, pp. 480–488, 2019.

@article{01GN78CKBAE94BQED3B54EAJDT,
  abstract     = {{Frailty is highly prevalent in old age and confers an important mortality risk. Although the causes of frailty are multiple, immunosenescence (IS)—predominantly driven by cytomegalovirus (CMV)—has been implicated in its pathophysiology. Thus far, research examining the association between IS and frailty states is sparse and equivocal. On the other hand, evidence is mounting in support of the view that frailty can be reversed, especially for those in the pre-frail stage. Therefore, we aimed to clarify the impact of CMV on IS and its relevance to pre-frailty.
One hundred seventy-three persons aged 80 to 99 years were enrolled. Pre-frailty was defined according to Fried’s criteria. Anti-CMV IgG and serum IL-6 were measured using Architect iSystem and Luminex, respectively. T-cell phenotypes were determined using flow cytometry. The prevalence of pre-frailty was 52.6%, increased with age (p = .001), and was greater in men than women (p = .044). No relationship was found between pre-frailty and positive CMV serology. Further, CMV-seropositivity was significantly associated with less naïve cells, more memory and senescence-prone phenotypes (all p < .001). After adjusting for potential confounders, only IL-6, age and sex were predictive of pre-frailty.
We conclude that the presence of pre-frailty is independent from CMV infection in very old subjects.}},
  author       = {{Hung, Cao Dinh and Bautmans, Ivan and Beyer, Ingo and Mets, Tony and Onyema, Oscar Okwudiri and Forti, Louis Nuvagah and Renmans, Wim and Vander Meeren, Sam and Jochmans, Kristin and Vermeiren, Sofie and Vella-Azzopardi, Roberta and Njemini, Rose and Verté, Dominique and Petrovic, Mirko and De Donder, Liesbeth and Kardol, Tinie and Rossi, Gina and Clarys, Peter and Scafoglieri, Aldo and Cattrysse, Eric and de Hert, Paul and Jansen, Bart}},
  issn         = {{1079-5006}},
  journal      = {{JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES}},
  keywords     = {{Senescence,Inflammation,Lymphocytes,Robust}},
  language     = {{eng}},
  number       = {{4}},
  pages        = {{480--488}},
  title        = {{Association between immunosenescence phenotypes and pre-frailty in older subjects : does cytomegalovirus play a role?}},
  url          = {{http://dx.doi.org/10.1093/gerona/gly135}},
  volume       = {{74}},
  year         = {{2019}},
}

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Association between immunosenescence phenotypes and pre-frailty in older subjects : does cytomegalovirus play a role?

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