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Walk-through total body PET : very efficient patient throughput and detector usage with low-cost monolithic high-resolution flat panel detectors

Florence Marie Muller (UGent) , Jens Maebe (UGent) , Nadia Withofs, Maya Abi Akl (UGent) , Meysam Dadgar (UGent) , Christian Vanhove (UGent) and Stefaan Vandenberghe (UGent)
(2022) Faculty of Engineering and Architecture Research Symposium 2022 (FEARS 2022), Abstracts.
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Abstract
Current Total Body Positron Emission Tomography (TB-PET) scanners come at high acquisition and installation costs which limits their implementation into more clinical use. Patient population and clinical needs see gradual changes on-going and expected in the future; and PET imaging will play a role not only for detection but also for therapy prediction and follow-up. To accommodate for the increasing number of patients and repeat scans, PET scanners should evolve towards: (i) lower dose imaging, (ii) faster imaging, (iii) lower cost (including system and procedure cost), and (iv) less personnel per scan. Furthermore, although current TB-PET systems have become so sensitive that 30-seconds body acquisitions seem feasible, practical patient throughput is limited by patient positioning on the bed. Our group proposes a novel design concept for TB-PET to go towards fast and lower dose imaging with higher patient throughput for lower component cost: a new flat panel high-resolution Walk Through (WT) TB-PET design with patients standing in upright position between two flat panels. Patient sizes measured from 40 random PET-CT scans defined the flat panel dimensions: 70 cm wide, 105 cm high and 50 cm gap. The footprint of the WT-TB-PET system is very small (about 2 m2) compared to the large installation space of current PET-CTs (30-40 m2). To investigate the extent of patient motion a WT-TB-PET mock-up was built. Motion analyses compared the impact of free-breathing vs breath-hold induced body motion in the WT-TB-PET. One further benefit of the design is the use of monolithic detectors: they offer high intrinsic spatial resolution (2 mm over the whole field-of-view), thereby outperforming classical pixelated detectors by a factor 2-3. Combined with the use of BGO (at 3x lower cost compared to current L(Y)SO), the estimated component cost is about 1.3 MEuro (comparable to the cost of a standard PET-CT).

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MLA
Muller, Florence Marie, et al. “Walk-through Total Body PET : Very Efficient Patient Throughput and Detector Usage with Low-Cost Monolithic High-Resolution Flat Panel Detectors.” Faculty of Engineering and Architecture Research Symposium 2022 (FEARS 2022), Abstracts, 2022, doi:10.5281/zenodo.7400445.
APA
Muller, F. M., Maebe, J., Withofs, N., Abi Akl, M., Dadgar, M., Vanhove, C., & Vandenberghe, S. (2022). Walk-through total body PET : very efficient patient throughput and detector usage with low-cost monolithic high-resolution flat panel detectors. Faculty of Engineering and Architecture Research Symposium 2022 (FEARS 2022), Abstracts. Presented at the Faculty of Engineering and Architecture Research Symposium 2022 (FEARS 2022), Ghent, Belgium. https://doi.org/10.5281/zenodo.7400445
Chicago author-date
Muller, Florence Marie, Jens Maebe, Nadia Withofs, Maya Abi Akl, Meysam Dadgar, Christian Vanhove, and Stefaan Vandenberghe. 2022. “Walk-through Total Body PET : Very Efficient Patient Throughput and Detector Usage with Low-Cost Monolithic High-Resolution Flat Panel Detectors.” In Faculty of Engineering and Architecture Research Symposium 2022 (FEARS 2022), Abstracts. https://doi.org/10.5281/zenodo.7400445.
Chicago author-date (all authors)
Muller, Florence Marie, Jens Maebe, Nadia Withofs, Maya Abi Akl, Meysam Dadgar, Christian Vanhove, and Stefaan Vandenberghe. 2022. “Walk-through Total Body PET : Very Efficient Patient Throughput and Detector Usage with Low-Cost Monolithic High-Resolution Flat Panel Detectors.” In Faculty of Engineering and Architecture Research Symposium 2022 (FEARS 2022), Abstracts. doi:10.5281/zenodo.7400445.
Vancouver
1.
Muller FM, Maebe J, Withofs N, Abi Akl M, Dadgar M, Vanhove C, et al. Walk-through total body PET : very efficient patient throughput and detector usage with low-cost monolithic high-resolution flat panel detectors. In: Faculty of Engineering and Architecture Research Symposium 2022 (FEARS 2022), Abstracts. 2022.
IEEE
[1]
F. M. Muller et al., “Walk-through total body PET : very efficient patient throughput and detector usage with low-cost monolithic high-resolution flat panel detectors,” in Faculty of Engineering and Architecture Research Symposium 2022 (FEARS 2022), Abstracts, Ghent, Belgium, 2022.
@inproceedings{01GMVAYWBG52XMV0WM2EAH8WQ8,
  abstract     = {{Current Total Body Positron Emission Tomography (TB-PET) scanners come at high acquisition and installation costs which limits their implementation into more clinical use. Patient population and clinical needs see gradual changes on-going and expected in the future; and PET imaging will play a role not only for detection but also for therapy prediction and follow-up. To accommodate for the increasing number of patients and repeat scans, PET scanners should evolve towards: (i) lower dose imaging, (ii) faster imaging, (iii) lower cost (including system and procedure cost), and (iv) less personnel per scan. Furthermore, although current TB-PET systems have become so sensitive that 30-seconds body acquisitions seem feasible, practical patient throughput is limited by patient positioning on the bed. Our group proposes a novel design concept for TB-PET to go towards fast and lower dose imaging with higher patient throughput for lower component cost: a new flat panel high-resolution Walk Through (WT) TB-PET design with patients standing in upright position between two flat panels. Patient sizes measured from 40 random PET-CT scans defined the flat panel dimensions: 70 cm wide, 105 cm high and 50 cm gap. The footprint of the WT-TB-PET system is very small (about 2 m2) compared to the large installation space of current PET-CTs (30-40 m2). To investigate the extent of patient motion a WT-TB-PET mock-up was built. Motion analyses compared the impact of free-breathing vs breath-hold induced body motion in the WT-TB-PET. One further benefit of the design is the use of monolithic detectors: they offer high intrinsic spatial resolution (2 mm over the whole field-of-view), thereby outperforming classical pixelated detectors by a factor 2-3. Combined with the use of BGO (at 3x lower cost compared to current L(Y)SO), the estimated component cost is about 1.3 MEuro (comparable to the cost of a standard PET-CT).}},
  author       = {{Muller, Florence Marie and Maebe, Jens and Withofs, Nadia and Abi Akl, Maya and Dadgar, Meysam and Vanhove, Christian and Vandenberghe, Stefaan}},
  booktitle    = {{Faculty of Engineering and Architecture Research Symposium 2022 (FEARS 2022), Abstracts}},
  language     = {{eng}},
  location     = {{Ghent, Belgium}},
  pages        = {{1}},
  title        = {{Walk-through total body PET : very efficient patient throughput and detector usage with low-cost monolithic high-resolution flat panel detectors}},
  url          = {{http://doi.org/10.5281/zenodo.7400445}},
  year         = {{2022}},
}
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