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Mucus-penetrating nanoparticles based on chitosan grafted with various non-ionic polymers : synthesis, structural characterisation and diffusion studies

Twana Mohammed M. Ways, Sergey K. Filippov, Samarendra Maji (UGent) , Mathias Glassner (UGent) , Michal Ceglowski (UGent) , Richard Hoogenboom (UGent) , Stephen King, Wing Man Lau and Vitaliy V. Khutoryanskiy
(2022) JOURNAL OF COLLOID AND INTERFACE SCIENCE. 626. p.251-264
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Abstract
Transmucosal administration offers numerous advantages for drug delivery as it usually helps to avoid first pass metabolism, provides rapid onset of action, and is a non-invasive route. Mucosal surfaces are covered by a viscoelastic mucus gel layer which acts as a protective barrier preventing the entrance of harmful substances into the human tissues. This function of mucus also inhibits the diffusion of drugs and nano-formulations and can result in a significant reduction of their efficacy. The design of mucuspenetrating nanoparticles can overcome the barrier function of mucus which may lead to better therapeutic outcomes. In this study, chitosan was chemically modified by grafting short chains of poly(ethylene glycol), poly(2-hydroxyethyl acrylate), poly(2-ethyl-2-oxazoline), or poly(N-vinyl pyrrolidone) and
Keywords
MUCOADHESIVE DRUG-DELIVERY, TRACKING ANALYSIS NTA, DOSAGE FORMS, SYSTEMS, POLYMERIZATION, PERMEABILITY, PEGYLATION, COPOLYMERS, SCATTERING, TRANSPORT, Chitosan, Nanoparticles, Mucus penetration, Diffusion, Drug delivery

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MLA
Ways, Twana Mohammed M., et al. “Mucus-Penetrating Nanoparticles Based on Chitosan Grafted with Various Non-Ionic Polymers : Synthesis, Structural Characterisation and Diffusion Studies.” JOURNAL OF COLLOID AND INTERFACE SCIENCE, vol. 626, 2022, pp. 251–64, doi:10.1016/j.jcis.2022.06.126.
APA
Ways, T. M. M., Filippov, S. K., Maji, S., Glassner, M., Ceglowski, M., Hoogenboom, R., … Khutoryanskiy, V. V. (2022). Mucus-penetrating nanoparticles based on chitosan grafted with various non-ionic polymers : synthesis, structural characterisation and diffusion studies. JOURNAL OF COLLOID AND INTERFACE SCIENCE, 626, 251–264. https://doi.org/10.1016/j.jcis.2022.06.126
Chicago author-date
Ways, Twana Mohammed M., Sergey K. Filippov, Samarendra Maji, Mathias Glassner, Michal Ceglowski, Richard Hoogenboom, Stephen King, Wing Man Lau, and Vitaliy V. Khutoryanskiy. 2022. “Mucus-Penetrating Nanoparticles Based on Chitosan Grafted with Various Non-Ionic Polymers : Synthesis, Structural Characterisation and Diffusion Studies.” JOURNAL OF COLLOID AND INTERFACE SCIENCE 626: 251–64. https://doi.org/10.1016/j.jcis.2022.06.126.
Chicago author-date (all authors)
Ways, Twana Mohammed M., Sergey K. Filippov, Samarendra Maji, Mathias Glassner, Michal Ceglowski, Richard Hoogenboom, Stephen King, Wing Man Lau, and Vitaliy V. Khutoryanskiy. 2022. “Mucus-Penetrating Nanoparticles Based on Chitosan Grafted with Various Non-Ionic Polymers : Synthesis, Structural Characterisation and Diffusion Studies.” JOURNAL OF COLLOID AND INTERFACE SCIENCE 626: 251–264. doi:10.1016/j.jcis.2022.06.126.
Vancouver
1.
Ways TMM, Filippov SK, Maji S, Glassner M, Ceglowski M, Hoogenboom R, et al. Mucus-penetrating nanoparticles based on chitosan grafted with various non-ionic polymers : synthesis, structural characterisation and diffusion studies. JOURNAL OF COLLOID AND INTERFACE SCIENCE. 2022;626:251–64.
IEEE
[1]
T. M. M. Ways et al., “Mucus-penetrating nanoparticles based on chitosan grafted with various non-ionic polymers : synthesis, structural characterisation and diffusion studies,” JOURNAL OF COLLOID AND INTERFACE SCIENCE, vol. 626, pp. 251–264, 2022.
@article{01GMB2BX6RPB3ZQDS6N7YQC2HW,
  abstract     = {{Transmucosal administration offers numerous advantages for drug delivery as it usually helps to avoid first pass metabolism, provides rapid onset of action, and is a non-invasive route. Mucosal surfaces are covered by a viscoelastic mucus gel layer which acts as a protective barrier preventing the entrance of harmful substances into the human tissues. This function of mucus also inhibits the diffusion of drugs and nano-formulations and can result in a significant reduction of their efficacy. The design of mucuspenetrating nanoparticles can overcome the barrier function of mucus which may lead to better therapeutic outcomes. In this study, chitosan was chemically modified by grafting short chains of poly(ethylene glycol), poly(2-hydroxyethyl acrylate), poly(2-ethyl-2-oxazoline), or poly(N-vinyl pyrrolidone) and}},
  author       = {{Ways, Twana Mohammed M. and  Filippov, Sergey K. and Maji, Samarendra and Glassner, Mathias and Ceglowski, Michal and Hoogenboom, Richard and  King, Stephen and  Lau, Wing Man and  Khutoryanskiy, Vitaliy V.}},
  issn         = {{0021-9797}},
  journal      = {{JOURNAL OF COLLOID AND INTERFACE SCIENCE}},
  keywords     = {{MUCOADHESIVE DRUG-DELIVERY,TRACKING ANALYSIS NTA,DOSAGE FORMS,SYSTEMS,POLYMERIZATION,PERMEABILITY,PEGYLATION,COPOLYMERS,SCATTERING,TRANSPORT,Chitosan,Nanoparticles,Mucus penetration,Diffusion,Drug delivery}},
  language     = {{eng}},
  pages        = {{251--264}},
  title        = {{Mucus-penetrating nanoparticles based on chitosan grafted with various non-ionic polymers : synthesis, structural characterisation and diffusion studies}},
  url          = {{http://doi.org/10.1016/j.jcis.2022.06.126}},
  volume       = {{626}},
  year         = {{2022}},
}
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