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Human gut microbiota stratified by (+)-catechin metabolism dynamics reveals colon region-dependent metabolic profile

Qiqiong Li (UGent) , Jan Stautemas (UGent) , Stanley Omondi Onyango (UGent) , Marjan De Mey (UGent) , Dries Duchi (UGent) , Emmy Tuenter, Nina Hermans, Patrick Calders (UGent) and Tom Van de Wiele (UGent)
(2023) FOOD CHEMISTRY. 408.
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Abstract
Catechins have proven to have several health benefits, yet a huge interindividual variability occurs. The meta-bolic potency of the colonic microbiota towards catechin is a key determinant of this variability. Microbiota from two donors - previously characterized as a fast and a slow converter- were incubated with (+)-catechin in vitro. The robustness of in vitro metabolic profiles was verified by well-fitted human trials. The colon region-dependent and donor-dependent patterns were reflected in both metabolic features and colonic microbiota composition. Upstream and downstream metabolites were mainly detected in the proximal and distal colons, respectively, and were considered important explanatory variables for microbiota clustering in the corresponding colon regions. Higher abundances of two catechin-metabolizing bacteria, Eggerthella and Flavonifractor were found in the distal colon compared to the proximal colon and in slow converter than fast converter. Additionally, these two bacteria were enriched in treatment samples compared to sham treatment samples.
Keywords
(+)-Catechin, Gut microbiota, Biotransformation, Eggerthella, Flavonifractor, metabolizing, Catechin-bacteria, M-SHIME

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MLA
Li, Qiqiong, et al. “Human Gut Microbiota Stratified by (+)-Catechin Metabolism Dynamics Reveals Colon Region-Dependent Metabolic Profile.” FOOD CHEMISTRY, vol. 408, 2023, doi:10.1016/j.foodchem.2022.135203.
APA
Li, Q., Stautemas, J., Onyango, S. O., De Mey, M., Duchi, D., Tuenter, E., … Van de Wiele, T. (2023). Human gut microbiota stratified by (+)-catechin metabolism dynamics reveals colon region-dependent metabolic profile. FOOD CHEMISTRY, 408. https://doi.org/10.1016/j.foodchem.2022.135203
Chicago author-date
Li, Qiqiong, Jan Stautemas, Stanley Omondi Onyango, Marjan De Mey, Dries Duchi, Emmy Tuenter, Nina Hermans, Patrick Calders, and Tom Van de Wiele. 2023. “Human Gut Microbiota Stratified by (+)-Catechin Metabolism Dynamics Reveals Colon Region-Dependent Metabolic Profile.” FOOD CHEMISTRY 408. https://doi.org/10.1016/j.foodchem.2022.135203.
Chicago author-date (all authors)
Li, Qiqiong, Jan Stautemas, Stanley Omondi Onyango, Marjan De Mey, Dries Duchi, Emmy Tuenter, Nina Hermans, Patrick Calders, and Tom Van de Wiele. 2023. “Human Gut Microbiota Stratified by (+)-Catechin Metabolism Dynamics Reveals Colon Region-Dependent Metabolic Profile.” FOOD CHEMISTRY 408. doi:10.1016/j.foodchem.2022.135203.
Vancouver
1.
Li Q, Stautemas J, Onyango SO, De Mey M, Duchi D, Tuenter E, et al. Human gut microbiota stratified by (+)-catechin metabolism dynamics reveals colon region-dependent metabolic profile. FOOD CHEMISTRY. 2023;408.
IEEE
[1]
Q. Li et al., “Human gut microbiota stratified by (+)-catechin metabolism dynamics reveals colon region-dependent metabolic profile,” FOOD CHEMISTRY, vol. 408, 2023.
@article{01GM5XKE53677AS0M7QZR2EGP8,
  abstract     = {{Catechins have proven to have several health benefits, yet a huge interindividual variability occurs. The meta-bolic potency of the colonic microbiota towards catechin is a key determinant of this variability. Microbiota from two donors - previously characterized as a fast and a slow converter- were incubated with (+)-catechin in vitro. The robustness of in vitro metabolic profiles was verified by well-fitted human trials. The colon region-dependent and donor-dependent patterns were reflected in both metabolic features and colonic microbiota composition. Upstream and downstream metabolites were mainly detected in the proximal and distal colons, respectively, and were considered important explanatory variables for microbiota clustering in the corresponding colon regions. Higher abundances of two catechin-metabolizing bacteria, Eggerthella and Flavonifractor were found in the distal colon compared to the proximal colon and in slow converter than fast converter. Additionally, these two bacteria were enriched in treatment samples compared to sham treatment samples.}},
  articleno    = {{135203}},
  author       = {{Li, Qiqiong and Stautemas, Jan and Onyango, Stanley Omondi and De Mey, Marjan and Duchi, Dries and Tuenter, Emmy and Hermans, Nina and Calders, Patrick and Van de Wiele, Tom}},
  issn         = {{0308-8146}},
  journal      = {{FOOD CHEMISTRY}},
  keywords     = {{(+)-Catechin,Gut microbiota,Biotransformation,Eggerthella,Flavonifractor,metabolizing,Catechin-bacteria,M-SHIME}},
  language     = {{eng}},
  pages        = {{11}},
  title        = {{Human gut microbiota stratified by (+)-catechin metabolism dynamics reveals colon region-dependent metabolic profile}},
  url          = {{http://doi.org/10.1016/j.foodchem.2022.135203}},
  volume       = {{408}},
  year         = {{2023}},
}
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