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Arsenolipids reduce butyrate levels and influence human gut microbiota in a donor-dependent way

Marta Calatayud Arroyo (UGent) , Chan Xiong, Marta Selma-Royo and Tom Van de Wiele (UGent)
(2022) ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY. 246.
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Abstract
Arsenolipids are organic arsenic species with variable toxicity. Accurate assessment of the risks derived from arsenic-contaminated seafood intake requires studying the interplay between arsenolipids and the human gut microbiota. This research used the in vitro mucosal simulator of the human intestinal microbial ecosystem (M-SHIME) to assess the effect of defined chemical standards of arsenolipids (AsFA 362 and AsHC 332) on a simulated healthy human gut microbiota (n = 4). Microbial-derived metabolites were quantified by gas chro-matography and microbiota structure was characterized by 16S rRNA gene sequencing. A specific reduction in butyrate production (control=5.28 +/- 0.3 mM; AsFAs=4.56 +/- 0.4 mM; AsHC 332=4.4 +/- 0.6 mM, n = 4 donors), concomitant with a reduction in the abundance of Lachnospiraceae UCG-004 group and the Faecalibacterium genus was observed, albeit in a donor-dependent manner. Furthermore, an increase in Escherichia/Shigella, Proteobacteria and Fusobacterium abundance was observed after arsenolipid treatments, depending on individual microbiota background. These alterations in microbial functionality and microbial community structure suggest a detrimental effect of arsenolipids intake towards the commensal gut microbiome, and consequently, on human health.
Keywords
Microbiota, M-SHIME, Dysbiosis, Toxicity, Arsenic -containing fatty, acid, Arsenic -containing hydrocarbon, VITRO TOXICOLOGICAL CHARACTERIZATION, FAECALIBACTERIUM-PRAUSNITZII, ARSENIC METABOLISM, EXPOSURE, PATTERNS, HEALTHY, BRAIN, SERUM, RATS

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MLA
Calatayud Arroyo, Marta, et al. “Arsenolipids Reduce Butyrate Levels and Influence Human Gut Microbiota in a Donor-Dependent Way.” ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY, vol. 246, 2022, doi:10.1016/j.ecoenv.2022.114175.
APA
Calatayud Arroyo, M., Xiong, C., Selma-Royo, M., & Van de Wiele, T. (2022). Arsenolipids reduce butyrate levels and influence human gut microbiota in a donor-dependent way. ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY, 246. https://doi.org/10.1016/j.ecoenv.2022.114175
Chicago author-date
Calatayud Arroyo, Marta, Chan Xiong, Marta Selma-Royo, and Tom Van de Wiele. 2022. “Arsenolipids Reduce Butyrate Levels and Influence Human Gut Microbiota in a Donor-Dependent Way.” ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY 246. https://doi.org/10.1016/j.ecoenv.2022.114175.
Chicago author-date (all authors)
Calatayud Arroyo, Marta, Chan Xiong, Marta Selma-Royo, and Tom Van de Wiele. 2022. “Arsenolipids Reduce Butyrate Levels and Influence Human Gut Microbiota in a Donor-Dependent Way.” ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY 246. doi:10.1016/j.ecoenv.2022.114175.
Vancouver
1.
Calatayud Arroyo M, Xiong C, Selma-Royo M, Van de Wiele T. Arsenolipids reduce butyrate levels and influence human gut microbiota in a donor-dependent way. ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY. 2022;246.
IEEE
[1]
M. Calatayud Arroyo, C. Xiong, M. Selma-Royo, and T. Van de Wiele, “Arsenolipids reduce butyrate levels and influence human gut microbiota in a donor-dependent way,” ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY, vol. 246, 2022.
@article{01GM2Y0MC5ZZGE37BM7YVVSQJ9,
  abstract     = {{Arsenolipids are organic arsenic species with variable toxicity. Accurate assessment of the risks derived from arsenic-contaminated seafood intake requires studying the interplay between arsenolipids and the human gut microbiota. This research used the in vitro mucosal simulator of the human intestinal microbial ecosystem (M-SHIME) to assess the effect of defined chemical standards of arsenolipids (AsFA 362 and AsHC 332) on a simulated healthy human gut microbiota (n = 4). Microbial-derived metabolites were quantified by gas chro-matography and microbiota structure was characterized by 16S rRNA gene sequencing. A specific reduction in butyrate production (control=5.28 +/- 0.3 mM; AsFAs=4.56 +/- 0.4 mM; AsHC 332=4.4 +/- 0.6 mM, n = 4 donors), concomitant with a reduction in the abundance of Lachnospiraceae UCG-004 group and the Faecalibacterium genus was observed, albeit in a donor-dependent manner. Furthermore, an increase in Escherichia/Shigella, Proteobacteria and Fusobacterium abundance was observed after arsenolipid treatments, depending on individual microbiota background. These alterations in microbial functionality and microbial community structure suggest a detrimental effect of arsenolipids intake towards the commensal gut microbiome, and consequently, on human health.}},
  articleno    = {{114175}},
  author       = {{Calatayud Arroyo, Marta and  Xiong, Chan and  Selma-Royo, Marta and Van de Wiele, Tom}},
  issn         = {{0147-6513}},
  journal      = {{ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY}},
  keywords     = {{Microbiota,M-SHIME,Dysbiosis,Toxicity,Arsenic -containing fatty,acid,Arsenic -containing hydrocarbon,VITRO TOXICOLOGICAL CHARACTERIZATION,FAECALIBACTERIUM-PRAUSNITZII,ARSENIC METABOLISM,EXPOSURE,PATTERNS,HEALTHY,BRAIN,SERUM,RATS}},
  language     = {{eng}},
  pages        = {{10}},
  title        = {{Arsenolipids reduce butyrate levels and influence human gut microbiota in a donor-dependent way}},
  url          = {{http://doi.org/10.1016/j.ecoenv.2022.114175}},
  volume       = {{246}},
  year         = {{2022}},
}
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