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Biochemical and insecticidal effects of plant essential oils on insecticide resistant and susceptible populations of Musca domestica L. point to a potential cross-resistance risk

Author
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Project
  • SuperPests (Innovative tools for rational control of the most difficult-to-manage pests (super pests) and the diseases they transmit)
  • POLYADAPT (Molecular-genetic mechanisms of extreme adaptation in a polyphagous agricultural pest)
Abstract
Essential oils (EOs) can provide important alternatives to chemical insecticides in the control of pests. In this study, 12 EOs of native plant species from Iran were evaluated for their adulticidal activity against the house fly. In addition, we examined the insecticidal activity of Zataria multiflora and Rosmarinus officinalis EOs on adult female house flies from pyrethroid and organophosphate resistant and susceptible populations, using both fumigant and topical bioassays. The involvement of detoxification enzymes in susceptibility was investigated with synergism experiments in vivo, while the inhibitory effects of R. officinalis and Zataria multiflora EOs on the activities of cytochrome P450-dependent monooxygenases (P450s), carboxylesterases (CarEs) and glutathione S- transferases (GSTs) were determined by enzymatic inhibition assays in vitro. The EOs of Z. multiflora, Mentha pulegium, R. officinalis and Thymus vulgaris were the most effective against adults in contact topical assays, while oils extracted from Eucalyptus cinerea, Z. multiflora, Citrus sinensis, R. officinalis, Pinus eldarica and Lavandula angustifolia where the most effective in fumigant assays. Rosmarinus officinalis and Z. multiflora EOs were selected for further investigation and showed higher toxicity against a susceptible population, compared to two insecticide-resistant populations. Correlation analysis suggested cross-resistance between these EOs and pyre-throids in the resistant populations. The toxicity of both EOs on the resistant populations was synergized by three detoxification enzyme inhibitors. Further, in vitro inhibition studies showed that R. officinalis and Z. multiflora EOs more effectively inhibited the activities of the detoxification enzymes from flies of the susceptible population compared to those of the pyrethroid resistant populations. Synergistic and enzymatic assays further revealed that increased activities of P450s, GSTs, and CarEs are possibly involved in the cross-resistance between EOs and pyrethroids. Investigating the molecular mechanisms of P450s, GSTs, and CarEs in the resistance to EOs should be subject to further studies.
Keywords
Essentialoils, Detoxifyingenzymes, Enzymeinhibition, MuscadomesticaL, Cross-resistance, Botanicalinsecticides

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Citation

Please use this url to cite or link to this publication:

MLA
Ahmadi, Ebrahim, et al. “Biochemical and Insecticidal Effects of Plant Essential Oils on Insecticide Resistant and Susceptible Populations of Musca Domestica L. Point to a Potential Cross-Resistance Risk.” PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY, vol. 184, 2022, doi:10.1016/j.pestbp.2022.105115.
APA
Ahmadi, E., Khajehali, J., Jonckheere, W., & Van Leeuwen, T. (2022). Biochemical and insecticidal effects of plant essential oils on insecticide resistant and susceptible populations of Musca domestica L. point to a potential cross-resistance risk. PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY, 184. https://doi.org/10.1016/j.pestbp.2022.105115
Chicago author-date
Ahmadi, Ebrahim, Jahangir Khajehali, Wim Jonckheere, and Thomas Van Leeuwen. 2022. “Biochemical and Insecticidal Effects of Plant Essential Oils on Insecticide Resistant and Susceptible Populations of Musca Domestica L. Point to a Potential Cross-Resistance Risk.” PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY 184. https://doi.org/10.1016/j.pestbp.2022.105115.
Chicago author-date (all authors)
Ahmadi, Ebrahim, Jahangir Khajehali, Wim Jonckheere, and Thomas Van Leeuwen. 2022. “Biochemical and Insecticidal Effects of Plant Essential Oils on Insecticide Resistant and Susceptible Populations of Musca Domestica L. Point to a Potential Cross-Resistance Risk.” PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY 184. doi:10.1016/j.pestbp.2022.105115.
Vancouver
1.
Ahmadi E, Khajehali J, Jonckheere W, Van Leeuwen T. Biochemical and insecticidal effects of plant essential oils on insecticide resistant and susceptible populations of Musca domestica L. point to a potential cross-resistance risk. PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY. 2022;184.
IEEE
[1]
E. Ahmadi, J. Khajehali, W. Jonckheere, and T. Van Leeuwen, “Biochemical and insecticidal effects of plant essential oils on insecticide resistant and susceptible populations of Musca domestica L. point to a potential cross-resistance risk,” PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY, vol. 184, 2022.
@article{01GKVJ9EFHZT84PGYABNRNV2CZ,
  abstract     = {{Essential oils (EOs) can provide important alternatives to chemical insecticides in the control of pests. In this study, 12 EOs of native plant species from Iran were evaluated for their adulticidal activity against the house fly. In addition, we examined the insecticidal activity of Zataria multiflora and Rosmarinus officinalis EOs on adult female house flies from pyrethroid and organophosphate resistant and susceptible populations, using both fumigant and topical bioassays. The involvement of detoxification enzymes in susceptibility was investigated with synergism experiments in vivo, while the inhibitory effects of R. officinalis and Zataria multiflora EOs on the activities of cytochrome P450-dependent monooxygenases (P450s), carboxylesterases (CarEs) and glutathione S- transferases (GSTs) were determined by enzymatic inhibition assays in vitro. The EOs of Z. multiflora, Mentha pulegium, R. officinalis and Thymus vulgaris were the most effective against adults in contact topical assays, while oils extracted from Eucalyptus cinerea, Z. multiflora, Citrus sinensis, R. officinalis, Pinus eldarica and Lavandula angustifolia where the most effective in fumigant assays. Rosmarinus officinalis and Z. multiflora EOs were selected for further investigation and showed higher toxicity against a susceptible population, compared to two insecticide-resistant populations. Correlation analysis suggested cross-resistance between these EOs and pyre-throids in the resistant populations. The toxicity of both EOs on the resistant populations was synergized by three detoxification enzyme inhibitors. Further, in vitro inhibition studies showed that R. officinalis and Z. multiflora EOs more effectively inhibited the activities of the detoxification enzymes from flies of the susceptible population compared to those of the pyrethroid resistant populations. Synergistic and enzymatic assays further revealed that increased activities of P450s, GSTs, and CarEs are possibly involved in the cross-resistance between EOs and pyrethroids. Investigating the molecular mechanisms of P450s, GSTs, and CarEs in the resistance to EOs should be subject to further studies.}},
  articleno    = {{105115}},
  author       = {{Ahmadi, Ebrahim and  Khajehali, Jahangir and Jonckheere, Wim and Van Leeuwen, Thomas}},
  issn         = {{0048-3575}},
  journal      = {{PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY}},
  keywords     = {{Essentialoils,Detoxifyingenzymes,Enzymeinhibition,MuscadomesticaL,Cross-resistance,Botanicalinsecticides}},
  language     = {{eng}},
  pages        = {{9}},
  title        = {{Biochemical and insecticidal effects of plant essential oils on insecticide resistant and susceptible populations of Musca domestica L. point to a potential cross-resistance risk}},
  url          = {{http://doi.org/10.1016/j.pestbp.2022.105115}},
  volume       = {{184}},
  year         = {{2022}},
}

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