- Author
- Helena Catharine Aegerter (UGent) , Bart Lambrecht (UGent) and Claudia V. Jakubzick
- Organization
- Project
- Abstract
- Tissue-resident alveolar and interstitial macrophages and recruited macrophages are critical players in innate immunity and maintenance of lung homeostasis. Until recently, assessing the differential functional contributions of tissue-resident versus recruited macrophages has been challenging because they share overlapping cell surface markers, making it difficult to separate them using conventional methods. This review describes how scRNA-seq and spatial transcriptomics can separate these subpopulations and help unravel the complexity of macrophage biology in homeostasis and disease. First, we provide a guide to identifying and distinguishing lung macrophages from other mononuclear phagocytes in humans and mice. Second, we outline emerging concepts related to the development and function of the various lung macrophages in the alveolar, perivascular, and interstitial niches. Finally, we describe how different tissue states profoundly alter their functions, including acute and chronic lung disease, cancer, and aging.
- Keywords
- Infectious Diseases, Immunology, Immunology and Allergy
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Citation
Please use this url to cite or link to this publication: http://hdl.handle.net/1854/LU-01GJQ216BJ6ZF8F0QMECE7J757
- MLA
- Aegerter, Helena Catharine, et al. “Biology of Lung Macrophages in Health and Disease.” IMMUNITY, vol. 55, no. 9, 2022, pp. 1564–80, doi:10.1016/j.immuni.2022.08.010.
- APA
- Aegerter, H. C., Lambrecht, B., & Jakubzick, C. V. (2022). Biology of lung macrophages in health and disease. IMMUNITY, 55(9), 1564–1580. https://doi.org/10.1016/j.immuni.2022.08.010
- Chicago author-date
- Aegerter, Helena Catharine, Bart Lambrecht, and Claudia V. Jakubzick. 2022. “Biology of Lung Macrophages in Health and Disease.” IMMUNITY 55 (9): 1564–80. https://doi.org/10.1016/j.immuni.2022.08.010.
- Chicago author-date (all authors)
- Aegerter, Helena Catharine, Bart Lambrecht, and Claudia V. Jakubzick. 2022. “Biology of Lung Macrophages in Health and Disease.” IMMUNITY 55 (9): 1564–1580. doi:10.1016/j.immuni.2022.08.010.
- Vancouver
- 1.Aegerter HC, Lambrecht B, Jakubzick CV. Biology of lung macrophages in health and disease. IMMUNITY. 2022;55(9):1564–80.
- IEEE
- [1]H. C. Aegerter, B. Lambrecht, and C. V. Jakubzick, “Biology of lung macrophages in health and disease,” IMMUNITY, vol. 55, no. 9, pp. 1564–1580, 2022.
@article{01GJQ216BJ6ZF8F0QMECE7J757,
abstract = {{Tissue-resident alveolar and interstitial macrophages and recruited macrophages are critical players in innate immunity and maintenance of lung homeostasis. Until recently, assessing the differential functional contributions of tissue-resident versus recruited macrophages has been challenging because they share overlapping cell surface markers, making it difficult to separate them using conventional methods. This review describes how scRNA-seq and spatial transcriptomics can separate these subpopulations and help unravel the complexity of macrophage biology in homeostasis and disease. First, we provide a guide to identifying and distinguishing lung macrophages from other mononuclear phagocytes in humans and mice. Second, we outline emerging concepts related to the development and function of the various lung macrophages in the alveolar, perivascular, and interstitial niches. Finally, we describe how different tissue states profoundly alter their functions, including acute and chronic lung disease, cancer, and aging.}},
author = {{Aegerter, Helena Catharine and Lambrecht, Bart and Jakubzick, Claudia V.}},
issn = {{1074-7613}},
journal = {{IMMUNITY}},
keywords = {{Infectious Diseases,Immunology,Immunology and Allergy}},
language = {{eng}},
number = {{9}},
pages = {{1564--1580}},
title = {{Biology of lung macrophages in health and disease}},
url = {{http://doi.org/10.1016/j.immuni.2022.08.010}},
volume = {{55}},
year = {{2022}},
}
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