Project: Evaluation of two markers of disease progression in patients involved in a clinical trial for HIV 1 therapy.
- project duration
- 01-JAN-00 – 31-DEC-99
- - Determination of the HIV 1 phenotype (syncytium inducing/non sycytium inducing), by culture of the HIV 1 isolate from the periferal blood cells of the patient, on MT2 cells. - Detection of AZT resistance by determination of the mutation ACC TAC or TTC on codon 215 of the reverse transcriptase gen. Determination of resistance is performed on viral RNA from plasma, using the LIPA technique (Innogenetics) or direct sequencing.