Ghent University Academic Bibliography


Project: Study for the total synthesis of (+)-biotin.

project duration
01-JAN-00 – 31-DEC-99
Biochemically, biotin functions as a coenzyme in fundamental processes such as the biosynthesis of fatty acids and the gluconeogenesis. In this project a new and efficient total synthesis of this vitamin is studied. An intramolecular (3+2)-cyclo-addition upon thermolysis of an acylazide constitutes one of the key transformations.