Project: Luminescent nanothermometers for theranostics
2020-05-01 – 2024-04-30
- Abstract
For diagnostic purposes temperature measurements in biomedicine are of key importance, as temperature plays an essential role in biological systems. For example, conditions such as inflammations and diseases such as cancer are accompanied by hyperlocal temperature changes in tissues. For biomedical applications measurements in the temperature range 20 – 50 ºC are essential (the so-called physiological range). Although detecting the temperature can be done employing robust, and already commercially available techniques, such as thermocouples or infrared imaging, optical temperature measurements (based on luminescence) at the nanoscale allow to reveal and study phenomena otherwise inaccessible to traditional thermometers such as measuring the temperature of cells and even the organelles within them.
Theranostics is a recently emerging field of interest, which combines diagnostics with therapy. In this regard, the use of nanomaterials, which allow combining multiple functions in just a single particle, would be able to change the entire healthcare scene and the way certain diseases are treated.
The goal of this project is to development novel types of nanothermometers for biomedical applications and additionally aim at using them for therapy means. The developed thermometers will rely on the temperature-dependent luminescence phenomena.
Although various thermometers have already been reported in literature, finding one which is suitable for biomedical purposes (non-toxic, excitable and showing emission in the biological windows, with high relative sensitivity, etc) is still a very challenging task. In this project we will tackle developing novel nanothermometers suitable for recording temperature in the physiological range based on lanthanide doped purely inorganic and well as hybrid nanomaterials. We will also aim at combing temperature sensing with drug delivery or Photo Dynamic Therapy in a single particle to obtain systems suitable for theranostics.
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- Journal Article
- A1
- open access
Exploring the potential of lanthanide-doped oxyfluoride materials for bright green upconversion and their promising applications towards temperature sensing and drug delivery
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Lanthanide-grafted hollow bipyridine-based periodic mesoporous organosilicas as chemical sensors
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- Journal Article
- A1
- open access
Turning 3D covalent organic frameworks into luminescent ratiometric temperature sensors
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Applications of hybrid luminescent (nano)thermometers
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Dual-mode vehicles with simultaneous thermometry and drug release properties based on hollow Y2O3:Er,Yb and Y2O2SO4:Er,Yb spheres
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- Journal Article
- A1
- open access
Hybrid lanthanide-doped rattle-type thermometers for theranostics
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- Journal Article
- A1
- open access
Ratiometric thermometers based on rhodamine B and fluorescein dye-incorporated (nano) cyclodextrin metal-organic frameworks
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Luminescent nanorattles based on bipyridine periodic mesoporous organosilicas for simultaneous thermometry and catalysis
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Hybrid NaYF4:Er,Yb@NaYF4@nano-MOF@AuNPs@LB composites for Yb3+-Er3+ physiological thermometry
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Hybrid nanocomposites formed by lanthanide nanoparticles in Zr-MOF for local temperature measurements during catalytic reactions