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Project: A 4-period, placebo-controlled, crossover study to evaluate the utility and feasibility of BOLD fMRI and cerbral blood flow measurement as biomarks for cognition enhancing drugs (donepezil and MK-3134)

05-SEP-07 – 30-NOV-07

The cholinergic neurotransmission enhancing drug donepezil (Aricept) has been shown to modulate fMRI signals associated with sensory perception and selective attention. This pilot study investigates the use of fMRI and perfusion measurements with MRI to detect effects of another categories of attention improving drugs.