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Project: A pharmacokinetic study in rabbits after oral administration of tilmicosin mixed in the feed

project duration
01-SEP-02 – 30-NOV-02
abstract
A study was performed with 16 healthy New-Zealand white rabbits which were treated orally during five consecutive days with tilmicosin mixed in the feed at a dose rate of 200 mg tilmicosin/kg feed. The aims of the study were to determine the pharmacokinetics of tilmicosin quantification in lung tissue and plasma and to develop and validate analytical methods to quantify tilmicosin in plasma, lung tissue and medicated rabbit feed.