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Project: Investigation of the uremic toxins responsible for the early atherogenesis and chronic inflammation in renal failure

project duration
01-OCT-02 – 30-SEP-06
abstract
It will be evaluated, via a systematic, experimental approach, which uremic retention solutes are playing a role in uremic inflammation, atherogenesis and impaired immune response. Primarily a fast screening of a broad panel of uremic solutes will be performed, followed by a search for the pathphysiological mechanisms. A board spectrum of aspects playing a role in atherogenesis, vascular disease and immunomodulation will be covered, thanks to a consortium of European investigation teams. Our group will concentrate on testsystems evaluating the effect on the function and respons of granulocytes/monocytes.