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Project: Inhibitors of the nonmenevalonate pathway of isoprenoid biosynthesis for the treatment of bacterial infection

project duration
01-MAR-04 – 28-FEB-07
abstract
This projects aims to validate several enzymes of the nonmevalonate pathway as druggable targets. We will focus on the synthesis of potential inhibitors (e.g. conformationally restrained fosmidomycin analogues) of DOXP reducto-isomerase and substrate analogues of the LytB enzyme.