Project: Role of apoE in the pathogenesis of Alzheimer disease in atherosclerosis.
- project duration
- 01-APR-96 – 31-DEC-99
- The objectives of this project is to utilize interdisciplinary approaches in order to study systematically how alterations in the structure of apoE affect its functions which lead to human disease. Special emphasis is placed on the role of apoE in the pathogenesis of Alzheimer's disease and atherosclerosis. Alterations in apoE which change its interactions with lipoprotein receptors, with the beta-amyloid peptide will be specially studied.