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Project: O2-sensitive targets

project duration
01-JAN-05 – 31-DEC-06
abstract
A mevalonate independent pathway of isoprenoid biosynthesis, the so-called DOXP pathway, has been discovered recently and validated as new drug target. The joint project aims at the development of inhibitors of the DOXP pathway as new antibacterial agents with a focus on the two enzymes catalyzing the lst two steps of the DOXP patwy, i.e. GcpE and LytB. Since these enzymes contain oxygen-sensitive iron-sulphur clusters, a screening