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Project: Inhibiting nef: a novel drug target for HIV-drug interactions

project duration
01-JAN-08 – 31-DEC-10
abstract
Efficacy of anti-retroviral therapy in HIV infected people is limited by the appearance of drug resistence. Non-enzyme drug targets need to be probed as alternative viral inhibition. The HIV Nef protein, shown to be an important determinant for in vivo pathogenicity, will be studied in this project as such a potential drug target for HIV host interactions.