Project FLUPIG: Pathogenesis and transmission of influenza in pigs (FLUPIG)
2010-07-01 – 2016-02-28
- Abstract
Pandemic influenza viruses originate from wild birds, but must adapt to efficient replication and transmission in humans to cause a pandemic. Pigs are considered important intermediate hosts where adaptation can occur. FLUPIG studies the genetic, host and environmental factors required for adaptation to mammals. Also, the role of cross-protective immunity on the occurrence and severity of a pandemic is studied.
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Could avian H9N2 influenza viruses become a threat to swine?: lessons from experimental studies in the pig
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Enhanced pig-to-pig transmission of a reassortant H9N2 influenza virus containing 2009 pandemic H1N1 internal genes by serial passaging in pigs
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A role for swine in the adaptation of H9N2 avian influenza viruses to humans?: lessons from serial passages and transmission studies in pigs