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Project: Gene-targeting of human pluripotent stem cells to study human T lymphocyte development and immune deficiencies

01/01/16 – 31/12/19

To obtain fundamental insights in normal T cell development and to investigate the applicability of genome-editing for gene therapy, we will manipulate the genome of human hematopoietic and pluripotent stem cells. This will allow a better correlation between genotypes and phenotypes in patients. A RAG2 knock-out model will be used as a reference.