Project: Genetics and physiology of bimodal protein targeting in yeasts. Studies on the basic mechanisms and possible therapeutic developments.
01/01/14 – 31/12/17
In this project we aim to understand the genetics and molecular biology of bimodal targeting of proteins in yeast. Whereas this mechanism has been described in mammalian cells, this is the first time that it has been found in yeasts. Bimodal targeting furthermore takes part in the acquisition of drug resistance in pathogenic yeasts, an aspect which is also addressed.