Project: Mechanisms of ferroptosis mediated immunoregulation
2022-01-01 – 2025-12-31
- Abstract
Ferroptosis is an iron-dependent, necrotic type of cell death driven by lipid peroxidation (LPO) in the plasma membrane. The efficient killing of cancer cells makes ferroptosis a compelling strategy for novel therapy treatments, but the relationship between ferroptosis and the immune system still form a blanc sheet for further research. We found that ferroptotic cells, despite abundant release of damage associated molecular patterns (DAMPs), cytokines and interferons, do not induce an immunological protection against cancer cells, in contrast to necrotic or other known ‘immunogenic’ cell death modalities. We found that dendritic cells exposed to ferroptotic cells fail to support antigen cross presentation, a prerequisite for an adaptive immune response. Oxygen and iron are Earth’s most abundant elements by number of atoms and by mass, respectively, and are at the core of the regulation and execution of ferroptosis. The central hypothesis of the project is that in a world full of oxygen and iron the occurrence of ferroptosis may have resulted in the coevolution of subroutine mechanisms that prevent strong host-mediated responses against the consequences of occasionally, accidently or pathologically occurring ferroptosis. In this project, we aim to identify the tolerance inducing factors (TIFs) and mechanisms how ferroptotic cells instruct dendritic cells (DCs) to tolerance as a way to avoid overreaction by sporadic, infection or trauma induced ferroptosis.
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- Journal Article
- A1
- open access
Harnessing luciferase chemistry in regulated cell death modalities and autophagy : overview and perspectives
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- Journal Article
- A1
- open access
The thymus road to a T cell : migration, selection, and atrophy
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- Journal Article
- A1
- open access
Ferroptosis in health and disease
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- Journal Article
- A1
- open access
TL1A and IL-18 synergy promotes GM-CSF-dependent thymic granulopoiesis in mice
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- Journal Article
- A1
- open access
Need for standardization of Influenza A virus-induced cell death in vivo to improve consistency of inter-laboratory research findings
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- Journal Article
- A1
- open access
RIPK1 protects naive and regulatory T cells from TNFR1-induced apoptosis
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- Journal Article
- A1
- open access
Type 1 immunity enables neonatal thymic ILC1 production
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- Journal Article
- A1
- open access
A guide to the expanding field of extracellular vesicles and their release in regulated cell death programs
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- Journal Article
- A1
- open access
NINJ1 is activated by cell swelling to regulate plasma membrane permeabilization during regulated necrosis
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- Journal Article
- A1
- open access
Systematic compositional analysis of exosomal extracellular vesicles produced by cells undergoing apoptosis, necroptosis and ferroptosis