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Project: Influence of creatine and uremic retention products on homocysteine metabolism, contractile and biochemical properties of striated muscle in an uremic animal model

project duration
01-JAN-04 – 31-DEC-07
abstract
End stage renal disease is complicated by uremic pyopathy. This is characterized by muscle weakness, fatigue, exhaustion upon minimal exercise. The underlying causes are multiple: anemia, hyperparathyroidism, metabloic acidosis, vit D deficiency, neuropathy and electrolyte abnormalities. This project investigates the effect of uremic retention products and creatine supplementation on biochemical and mechanical properties of the striated muscle and homocystein metabolism in uremia.