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Project: Integration of Notch signaling in human T cell development

project duration
01-JAN-07 – 31-DEC-10
abstract
Notch signaling is critical for the generation of immuuncompetent T lymphocytes out of hematopoietic stem cells. However, this pathway by itself is insufficient to drive T cell development. In this project, we study the role of the individual components of the Notch signaling pathway and its interactionpartners that, together with Notch, drive human T cell development.