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Project: An original concept toward the development of selective agonists for an engineered functional adenosine A3 receptor

01-JAN-04 – 31-DEC-07

This project uses the concept of chemical engineering to accomplish stimulation of adenosine A3 receptors at specific anatomical or physiological sites. Key elements of this strategy include: (i) modification of the receptor to allow selective recognition and activation by synthetic ligands (NEOCEPTOR) (ii) synthesis of novel agonists with high affinity for this neoceptor, but moderate affinity for the wild type receptor (NEOLIGANDS) (iii) selective expression of the neoceptor at the target organ.