Project: Longitudinal study of Chronic Obstructive Pulmonary Disease and Frailty
2018-01-01 – 2021-12-31
- Abstract
The demographic change is a great challenge for social welfare systems. Healthy aging is threatened by prevalent syndromes in the elderly including Chronic Obstructive Pulmonary Disease (COPD) and frailty. Both are associated with substantial morbidity, disability and mortality, though their interrelationship is insufficiently investigated. COPD is characterized by persistent airflow limitation and chronic inflammation of the airways and lungs. Frailty is the inability to compensate function loss. In this interuniversity and multidisciplinary project, we will elucidate the incidence of frailty in the Rotterdam Study, a large prospective population-based cohort study of 15.000 participants with more than 25 years follow-up, including 2.000 subjects with COPD. Secondly, we will unravel the underlying pathophysiology of the onset of frailty, including the role of exacerbations, inflammation, and sarcopenia. Thanks to a better understanding of incident frailty in subjects with and without COPD, we will be able to identify new targets to prevent and treat two devastating syndromes in the elderly. Finally, we will develop a prognostic index for vulnerable elderly in the community and validate it within the BELFRAIL elderly cohort. By providing more objectively estimated probabilities, individuals are better informed regarding their prognosis and health care professionals are aided in their reasoning and decision making regarding further management including withholding treatments.
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- Journal Article
- A1
- open access
Oral corticosteroid use and sarcopenia-related traits in older people with chronic airway disease : a population-based study
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- Journal Article
- A1
- open access
Frailty transitions in older persons with lung function impairment : a population-based study
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- Journal Article
- A1
- open access
IL-10 producing regulatory B cells are decreased in blood from smokers and COPD patients
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- Journal Article
- A1
- open access
Serum immunoglobulins, pneumonia risk, and lung function in middle-aged and older individuals : a population-based cohort study
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- Journal Article
- A1
- open access
Precision medicine from a citizen perspective : a survey of public attitudes towards pharmacogenomics in Flanders
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Lung function impairment in relation to cognition and vascular brain lesions : the Rotterdam Study
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- Journal Article
- A1
- open access
Sarcopenia, systemic immune-inflammation index and all-cause mortality in middle-aged and older people with COPD and asthma : a population-based study
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- Journal Article
- A1
- open access
Comparison of cerebral blood flow in subjects with and without chronic obstructive pulmonary disease from the population-based Rotterdam Study